{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:55:09Z","timestamp":1790848509806,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Nisin (Ni) is a polypeptide bacteriocin produced by lactic streptococci (probiotics) that can inhibit the majority of gram-positive bacteria, and improve the growth performance of broilers, and exert antioxidative and anti-inflammatory properties. The present study investigated the potential preventive effect of Nisin on necrotic enteritis induced by Clostridium perfringens (Cp) challenge. A total of 288 Arbor Acres broiler chickens of 1-d-olds were allocated using 2\u2005\u00d7\u20052 factorial arrangement into four groups with six replicates (12 chickens per replicate), including: (1) control group (Con, basal diet), (2) Cp challenge group (Cp, basal diet\u2005+\u20051.0\u2005\u00d7\u2005108 CFU\/mL Cp), (3) Ni group (Ni, basal diet\u2005+\u2005100\u00a0mg\/kg Ni), and (4) Ni\u2005+\u2005Cp group (Ni\u2005+\u2005Cp, basal diet\u2005+\u2005100\u00a0mg\/kg Ni\u2005+\u20051.0\u2005\u00d7\u2005108 CFU\/mL Cp). The results showed that Cp challenge decreased the average daily gain (ADG) of days 15 to 21 (P&amp;lt;0.05) and increased interleukin-6 (IL-6) content in the serum (P\u2005&amp;lt;\u20050.05), as well as a significant reduction in villus height (VH) and the ratio of VH to crypt depth (VCR) (P&amp;lt;0.05) and a significant increase in crypt depth (CD) of jejunum (P&amp;lt;0.05). Furthermore, the mRNA expressions of Occludin and Claudin-1 were downregulated (P&amp;lt;0.05), while the mRNA expressions of Caspase3, Caspase9, Bax, and Bax\/Bcl-2 were upregulated (P&amp;lt;0.05) in the jejunum. However, the inclusion of dietary Ni supplementation significantly improved body weight (BW) on days 21 and 28, ADG of days 15 to 21 (P&amp;lt;0.05), decreased CD in the jejunum, and reduced tumor necrosis factor-\u03b1 (TNF-\u03b1) content in the serum (P&amp;lt;0.05). Ni addition upregulated the mRNA levels of Claudin-1 expression and downregulated the mRNA expression levels of Caspase9 in the jejunum (P&amp;lt;0.05). Moreover, Cp challenge and Ni altered the cecal microbiota composition, which manifested that Cp challenge decreased the relative abundance of phylum Fusobacteriota and increased Shannon index (P&amp;lt;0.05) and the trend of phylum Proteobacteria (0.05&amp;lt;P&amp;lt;0.10), while Ni addition increased the relative abundance of phylum Cyanobacteria (P&amp;lt;0.05). In conclusion, the results demonstrated that the addition of Ni effectively mitigated the negative impact of Cp challenge-induced the damage of growth performance and intestine in broilers via reducing inflammatory responses and intestinal apoptosis and modulating cecal microbial composition.<\/jats:p>","DOI":"10.1093\/jas\/skae017","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T18:43:24Z","timestamp":1706121804000},"source":"Crossref","is-referenced-by-count":14,"title":["Effects of dietary Nisin on growth performance, immune function, and gut health of broilers challenged by <i>Clostridium perfringens<\/i>"],"prefix":"10.1093","volume":"102","author":[{"given":"Hua","family":"Yuan","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University , Harbin 150030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangdong","family":"Bai","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University , Harbin 150030 , China"},{"name":"College of Animal Science and Technology, Southwest University , Chongqing 400715 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University , Harbin 150030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilong","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University , Harbin 150030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghui","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University , Harbin 150030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renkai","family":"Dou","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University , Harbin 150030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University , Harbin 150030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University , Harbin 150030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyu","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University , Harbin 150030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University , Harbin 150030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangmei","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University , Harbin 150030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"2024072613471945500_CIT0001","doi-asserted-by":"crossref","first-page":"101590","DOI":"10.1016\/j.psj.2021.101590","article-title":"Necrotic enteritis in broiler chickens: disease characteristics and prevention using organic antibiotic alternatives \u2013 a comprehensive review","volume":"101","author":"Abd El-Hack","year":"2022","journal-title":"Poult. 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