{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:10:24Z","timestamp":1790914224908,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972579"],"award-info":[{"award-number":["31972579"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Province Major Science and Technology Special Projects","award":["2021ZDZX0009"],"award-info":[{"award-number":["2021ZDZX0009"]}]},{"name":"Sichuan Pig Innovation Team of National Modern Agricultural Industry Technology System of China","award":["scsztd-2023-08-11"],"award-info":[{"award-number":["scsztd-2023-08-11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This experiment was conducted to explore the effects of dietary synbiotics (SYB) supplementation on growth performance, immune function, and intestinal barrier function in piglets challenged with porcine epidemic diarrhea virus (PEDV). Forty crossbred (Duroc\u2005\u00d7\u2005Landrace\u2005\u00d7\u2005Yorkshire) weaned piglets (26\u2005\u00b1\u20051\u00a0d old) with a mean body weight (BW) of 6.62\u2005\u00b1\u20050.36\u00a0kg were randomly allotted to five groups: control (CON) I and CONII group, both fed basal diet; 0.1% SYB group, 0.2% SYB group, and 0.2% yeast culture (YC) group, fed basal diet supplemented with 0.1%, 0.2% SYB, and 0.2% YC, respectively. On day 22, all piglets were orally administrated with 40\u00a0mL PEDV (5.6\u2005\u00d7\u2005103 TCID50\/mL) except piglets in CONI group, which were administrated with the same volume of sterile saline. The trial lasted for 26\u00a0d. Before PEDV challenge, dietary 0.1% SYB supplementation increased final BW, average daily gain (ADG), and decreased the ratio of feed to gain during 0 to 21\u00a0d (P\u2005&amp;lt;\u20050.05), as well as improved the apparent nutrient digestibility of dry matter (DM), organic matter (OM), crude protein, ether extract (EE), and gross energy (GE). At the same time, 0.2% YC also improved the apparent nutrient digestibility of DM, OM, EE, and GE (P\u2005&amp;lt;\u20050.05). PEDV challenge increased diarrhea rate and diarrhea indexes while decreased ADG (P\u2005&amp;lt;\u20050.05) from days 22 to 26, and induced systemic and intestinal mucosa innate immune and proinflammatory responses, destroyed intestinal barrier integrity. The decrease in average daily feed intake and ADG induced by PEDV challenge was suppressed by dietary SYB and YC supplementation, and 0.1% SYB had the best-alleviating effect. Dietary 0.1% SYB supplementation also increased serum interleukin (IL)-10, immunoglobulin M, complement component 4, and jejunal mucosal IL-4 levels, while decreased serum diamine oxidase activity compared with CONII group (P\u2005&amp;lt;\u20050.05). Furthermore, 0.1% SYB improved mRNA expressions of claudin-1, zonula occludens protein-1, mucin 2, interferon-\u03b3, interferon regulatory factor-3, signal transducers and activators of transcription (P\u2005&amp;lt;\u20050.05), and protein expression of occludin, and downregulated mRNA expressions of toll-like receptor 3 and tumor necrosis factor-\u03b1 (P\u2005&amp;lt;\u20050.05) in jejunal mucosa. Supplementing 0.2% SYB or 0.2% YC also had a positive effect on piglets, but the effect was not as good as 0.1% SYB. These results indicated that dietary 0.1% SYB supplementation improved growth performance under normal conditions, and alleviated the inflammatory response and the damage of intestinal barrier via improving innate immune function and decreasing PEDV genomic copies, showed optimal protective effects against PEDV infection.<\/jats:p>","DOI":"10.1093\/jas\/skae023","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T12:26:56Z","timestamp":1706099216000},"source":"Crossref","is-referenced-by-count":13,"title":["Synbiotics improve growth performance and nutrient digestibility, inhibit PEDV infection, and prevent intestinal barrier dysfunction by mediating innate antivirus immune response in weaned piglets"],"prefix":"10.1093","volume":"102","author":[{"given":"Luhong","family":"Luo","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, Ministry of Agriculture and Rural Affairs, Key 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