{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:42:37Z","timestamp":1790725357878,"version":"4.1.0"},"reference-count":78,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Objectives were to examine the temporal pattern of intestinal mast cell dynamics and the effects of a mast cell stabilizer (ketotifen [Ket]) during acute heat stress (HS) in growing pigs. Crossbred barrows (n\u2005=\u200542; 32.3\u2005\u00b1\u20051.9\u00a0kg body weight [BW]) were randomly assigned to 1 of 7 environmental-therapeutic treatments: (1) thermoneutral (TN) control (TNCon; n\u2005=\u20056), (2) 2\u00a0h HS control (2\u00a0h HSCon; n\u2005=\u20056), (3) 2\u00a0h HS\u2005+\u2005Ket (2\u00a0h HSKet; n\u2005=\u20056); (4) 6\u00a0h HSCon (n\u2005=\u20056), (5) 6\u00a0h HSKet (n\u2005=\u20056), (6) 12\u00a0h HSCon (n\u2005=\u20056), or (7) 12\u00a0h HSKet (n\u2005=\u20056). Following 5\u00a0d of acclimation to individual pens, pigs were enrolled in two experimental periods (P). During P1 (3\u00a0d), pigs were housed in TN conditions (21.5\u2005\u00b1\u20050.8\u00a0\u00b0C) for the collection of baseline measurements. During P2, TNCon pigs remained in TN conditions for 12\u00a0h, while HS pigs were exposed to constant HS (38.1\u2005\u00b1\u20050.2\u00a0\u00b0C) for either 2, 6, or 12\u00a0h. Pigs were euthanized at the end of P2, and blood and tissue samples were collected. Regardless of time or therapeutic treatment, pigs exposed to HS had increased rectal temperature, skin temperature, and respiration rate compared to their TNCon counterparts (1.9\u00a0\u00b0C, 6.9\u00b0\u00a0C, and 119 breaths\/min; P\u2005&amp;lt;\u20050.01). As expected, feed intake and BW gain markedly decreased in HS pigs relative to their TNCon counterparts (P\u2005&amp;lt;\u20050.01). Irrespective of therapeutic treatment, circulating corticotropin-releasing factor decreased from 2 to 12\u00a0h of HS relative to TNCon pigs (P\u2005&amp;lt;\u20050.01). Blood cortisol increased at 2\u00a0h of HS (2-fold; P\u2005=\u20050.04) and returned to baseline by 6\u00a0h. Plasma histamine (a proxy of mast cell activation) remained similar across thermal treatments and was not affected by Ket administration (P\u2005&amp;gt;\u20050.54). Independent of Ket or time, HS increased mast cell numbers in the jejunum (94%; P\u2005&amp;lt;\u20050.01); however, no effects of HS on mast cell numbers were detected in the ileum or colon. Jejunum and ileum myeloperoxidase area remained similar among treatments (P\u2005&amp;gt;\u20050.58) but it tended to increase (12%; P\u2005=\u20050.08) in the colon in HSCon relative to TNCon pigs. Circulating lymphocytes and basophils decreased in HSKet relative to TN and HSCon pigs (P\u2005\u2264\u20050.06). Blood monocytes and eosinophils were reduced in HS pigs relative to their TNCon counterparts (P\u2005&amp;lt;\u20050.01). In summary, HS increased jejunum mast cell numbers and altered leukocyte dynamics and proinflammatory biomarkers. However, Ket administration had no effects on mast cell dynamics measured herein.<\/jats:p>","DOI":"10.1093\/jas\/skae030","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T23:57:41Z","timestamp":1706659061000},"source":"Crossref","is-referenced-by-count":6,"title":["Investigating intestinal mast cell dynamics during acute heat stress in growing pigs"],"prefix":"10.1093","volume":"102","author":[{"given":"Edith J","family":"Mayorga","sequence":"first","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Rodriguez-Jimenez","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan A","family":"Abeyta","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brady M","family":"Goetz","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Opgenorth","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J","family":"Moeser","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University , East Lansing, MI 48824 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance H","family":"Baumgard","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"2024022318564974600_CIT0001","first-page":"4599","article-title":"The effect of recovery from heat stress on circulating bioenergetics and inflammatory biomarkers","volume":"96","author":"Abuajamieh","year":"2018","journal-title":"J. Anim. Sci."},{"key":"2024022318564974600_CIT0002","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3390\/cells8020135","article-title":"Intestinal mucosal mast cells: key modulators of barrier function and homeostasis","volume":"8","author":"Albert-Bayo","year":"2019","journal-title":"Cells."},{"key":"2024022318564974600_CIT0003","doi-asserted-by":"crossref","first-page":"9634","DOI":"10.3168\/jds.2020-18721","article-title":"Effects of a Saccharomyces cerevisiae fermentation product on heat-stressed dairy cows","volume":"103","author":"Al-Qaisi","year":"2020","journal-title":"J. Dairy Sci."},{"key":"2024022318564974600_CIT0004","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1189\/jlb.2HI0317-088RR","article-title":"Frontline Science: corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology","volume":"102","author":"Ayyadurai","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"2024022318564974600_CIT0005","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-animal-031412-103644","article-title":"Effects of heat stress on postabsorptive metabolism and energetics","volume":"1","author":"Baumgard","year":"2013","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"2024022318564974600_CIT0006","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.3168\/jds.2011-4462","article-title":"Postabsorptive carbohydrate adaptations to heat stress and monensin supplementation in lactating Holstein cows","volume":"94","author":"Baumgard","year":"2011","journal-title":"J. Dairy Sci."},{"key":"2024022318564974600_CIT0007","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1006\/frne.1995.1013","article-title":"Corticotropin releasing factor (CRF) binding protein: a novel regulator of CRF and related peptides","volume":"16","author":"Behan","year":"1995","journal-title":"Front. Neuroendocrinol."},{"key":"2024022318564974600_CIT0008","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1158\/1535-7163.MCT-19-0123","article-title":"Ketotifen modulates mast cell chemotaxis to kit-ligand, but does not impact mast cell numbers, degranulation, or tumor behavior in neurofibromas of NF1-deficient mice","volume":"18","author":"Burks","year":"2019","journal-title":"Mol. Cancer Ther."},{"key":"2024022318564974600_CIT0009","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1097\/00003246-200008000-00037","article-title":"Hypocalcemia during porcine endotoxemic shock: effects of calcium administration","volume":"28","author":"Carlstedt","year":"2000","journal-title":"Crit. Care Med."},{"key":"2024022318564974600_CIT0010","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.physiol.67.040403.120816","article-title":"Endocrinology of the stress response","volume":"67","author":"Charmandari","year":"2005","journal-title":"Annu. Rev. Physiol."},{"key":"2024022318564974600_CIT0011","doi-asserted-by":"crossref","first-page":"14606","DOI":"10.1038\/s41598-018-32886-1","article-title":"Exposure to heat-stress environment affects the physiology, circulation levels of cytokines, and microbiome in dairy cows","volume":"8","author":"Chen","year":"2018","journal-title":"Sci. Rep."},{"key":"2024022318564974600_CIT0012","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1079\/BJN2001356","article-title":"Effect of high temperature on feeding behavior and heat production in group-housed young pigs","volume":"86","author":"Collin","year":"2001","journal-title":"Br. J. Nutr."},{"key":"2024022318564974600_CIT0013","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1182\/blood-2013-02-486217","article-title":"Mast cell and macrophage chemokines CXCL1\/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation","volume":"121","author":"De Filippo","year":"2013","journal-title":"Blood."},{"key":"2024022318564974600_CIT0014","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s12192-009-0129-6","article-title":"LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: possible role of NF-kappaB","volume":"15","author":"Dokladny","year":"2010","journal-title":"Cell Stress Chaperones."},{"key":"2024022318564974600_CIT0015","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s12917-020-02444-x","article-title":"Development of a computer-based quantification method for immunohistochemically-stained tissues and its application to study mast cells in equine wound healing (proof of concept)","volume":"16","author":"Dubuc","year":"2020","journal-title":"BMC Vet. Res."},{"key":"2024022318564974600_CIT0016","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1136\/gut.33.11.1498","article-title":"Ketotifen effectively prevents mucosal damage in experimental colitis","volume":"33","author":"Eliakim","year":"1992","journal-title":"Gut."},{"key":"2024022318564974600_CIT0017","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.3748\/wjg.v13.i22.3027","article-title":"Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots: stress, intestinal hyperpermeability and inflammation","volume":"13","author":"Farhadi","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"2024022318564974600_CIT0018","first-page":"169","volume-title":"Guide for care and use of agricultural animals in research and teaching","author":"FASS","year":"2010","edition":"3rd ed"},{"key":"2024022318564974600_CIT0019","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2165\/00007256-200131010-00004","article-title":"Alterations in energy metabolism during exercise and heat stress","volume":"31","author":"Febbraio","year":"2001","journal-title":"Sports Med."},{"key":"2024022318564974600_CIT0020","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3923\/ijps.2014.260.271","article-title":"Effects of dietary antioxidant on performance and physiological responses following heat stress in laying hens","volume":"13","author":"Felver-Gant","year":"2014","journal-title":"Int. J. Poult. Sci."},{"key":"2024022318564974600_CIT0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/tas\/txx003","article-title":"Diurnal heat stress reduces pig intestinal integrity and increases endotoxin translocation","volume":"2","author":"Gabler","year":"2018","journal-title":"Transl. Anim. Sci."},{"key":"2024022318564974600_CIT0022","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1152\/jappl.1966.21.2.631","article-title":"Plasma and sweat histamine concentrations after heat exposure and physical exercise","volume":"21","author":"Garden","year":"1966","journal-title":"J. Appl. Physiol."},{"key":"2024022318564974600_CIT0023","doi-asserted-by":"crossref","first-page":"R195","DOI":"10.1152\/ajpregu.00393.2005","article-title":"Heat stress increases apical glucose transport in the chicken jejunum","volume":"290","author":"Garriga","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2024022318564974600_CIT0024","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/10253890.2018.1470238","article-title":"Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility","volume":"21","author":"Gjerstad","year":"2018","journal-title":"Stress."},{"key":"2024022318564974600_CIT0025","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1677\/joe.1.06262","article-title":"Gastric immunolocalization and plasma profiles of acyl-ghrelin in fasted and fasted-refed prepubertal gilts","volume":"186","author":"Govoni","year":"2005","journal-title":"J. Endocrinol."},{"key":"2024022318564974600_CIT0026","first-page":"G1195","article-title":"Splanchnic tissues undergo hypoxic stress during whole body hyperthermia","volume":"276","author":"Hall","year":"1999","journal-title":"Am. J. Physiol."},{"key":"2024022318564974600_CIT0027","doi-asserted-by":"crossref","first-page":"H509","DOI":"10.1152\/ajpheart.2001.280.2.H509","article-title":"Mechanism of circulatory and intestinal barrier dysfunction during whole body hyperthermia","volume":"280","author":"Hall","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2024022318564974600_CIT0028","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fimmu.2012.00119","article-title":"Mast cell chemotaxis - chemoattractants and signaling pathways","volume":"3","author":"Halova","year":"2012","journal-title":"Front. Immunol."},{"key":"2024022318564974600_CIT0029","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.3382\/ps.2010-00715","article-title":"Effect of acute heat stress on calcium concentration, proliferation, cell cycle, and interleukin-2 production in splenic lymphocytes from broiler chickens","volume":"89","author":"Han","year":"2010","journal-title":"Poult. Sci."},{"key":"2024022318564974600_CIT0030","doi-asserted-by":"crossref","first-page":"7472","DOI":"10.3168\/jds.2020-18268","article-title":"Effects of maintaining eucalcemia following immunoactivation in lactating Holstein dairy cows","volume":"103","author":"Horst","year":"2020","journal-title":"J. Dairy Sci."},{"key":"2024022318564974600_CIT0031","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1399-3038.2007.00535.x","article-title":"Suppressive effects of ketotifen on Th1- and Th2-related chemokines of monocytes","volume":"18","author":"Hung","year":"2007","journal-title":"Pediatr. Allergy Immunol."},{"key":"2024022318564974600_CIT0032","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1186\/s40104-018-0264-y","article-title":"Lipopolysaccharide immune stimulation but not \u03b2-mannanase supplementation affects maintenance energy requirements in young weaned pigs","volume":"9","author":"Huntley","year":"2018","journal-title":"J. Anim. Sci. Biotech."},{"key":"2024022318564974600_CIT0033","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1152\/japplphysiol.00685.2015","article-title":"Rapid cooling after acute hyperthermia alters intestinal morphology and increases the systemic inflammatory response in pigs","volume":"120","author":"Johnson","year":"2016","journal-title":"J. Appl. Physiol. (1985)."},{"key":"2024022318564974600_CIT0034","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1017\/S1751731114001268","article-title":"Heat stress upregulation of Toll-like receptors 2\/4 and acute inflammatory cytokines in peripheral blood mononuclear cell (PBMC) of Bama miniature pigs: an in vivo and in vitro study","volume":"8","author":"Ju","year":"2014","journal-title":"Animal."},{"key":"2024022318564974600_CIT0035","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/j.1440-1746.2005.03767.x","article-title":"Ketotifen abrogates local and systemic consequences of rat intestinal ischemia-reperfusion injury","volume":"20","author":"Kalia","year":"2005","journal-title":"J. Gastroenterol. Hepatol."},{"key":"2024022318564974600_CIT0036","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/ajae\/aau002","article-title":"Potential effects of climate change on the productivity of U. S. dairies","volume":"96","author":"Key","year":"2014","journal-title":"Am. J. Agric. Econ."},{"key":"2024022318564974600_CIT0037","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1136\/gut.2010.213108","article-title":"The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome","volume":"59","author":"Klooker","year":"2010","journal-title":"Gut."},{"key":"2024022318564974600_CIT0038","doi-asserted-by":"crossref","first-page":"10333","DOI":"10.1073\/pnas.1820130116","article-title":"Heat stress directly impairs gut integrity and recruits distinct immune cell populations into the bovine intestine","volume":"116","author":"Koch","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2024022318564974600_CIT0039","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.2527\/jas2017.1830","article-title":"Estimating glucose requirements of an activated immune system in growing pigs","volume":"95","author":"Kvidera","year":"2017","journal-title":"J. Anim. Sci."},{"key":"2024022318564974600_CIT0040","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1152\/japplphysiol.00787.2001","article-title":"Selected contribution: hyperthermia-induced intestinal permeability and the role of oxidative and nitrosative stress","volume":"92","author":"Lambert","year":"2002","journal-title":"J. Appl. Physiol. (1985)."},{"key":"2024022318564974600_CIT0041","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0079-6123(06)62024-4","article-title":"Heat stroke and cytokines","volume":"162","author":"Leon","year":"2007","journal-title":"Prog. Brain Res."},{"key":"2024022318564974600_CIT0042","doi-asserted-by":"crossref","first-page":"e0171617","DOI":"10.1371\/journal.pone.0171617","article-title":"Chronic social stress in pigs impairs intestinal barrier and nutrient transporter function, and alters neuro-immune mediator and receptor expression","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One."},{"key":"2024022318564974600_CIT0043","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/B978-0-7234-3658-4.00021-4","article-title":"17-Anaphylaxis","volume-title":"Allergy","author":"Lieberman","year":"2012","edition":"4th ed"},{"key":"2024022318564974600_CIT0044","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.3748\/wjg.v25.i27.3503","article-title":"Eosinophils in the gastrointestinal tract and their role in the pathogenesis of major colorectal disorders","volume":"25","author":"Loktionov","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"2024022318564974600_CIT0045","first-page":"118","article-title":"Effects of mitoquinol during acute heat stress exposure in growing pigs","volume":"98","author":"Mayorga","year":"2020","journal-title":"J. Anim. Sci."},{"key":"2024022318564974600_CIT0046","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jas\/skab145","article-title":"Rapamycin administration during an acute heat stress challenge in growing pigs","volume":"99","author":"Mayorga","year":"2021","journal-title":"J. Anim. Sci."},{"key":"2024022318564974600_CIT0047","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/s12917-015-0588-1","article-title":"Cromolyn-mediated improvement of intestinal barrier function is associated with enhanced piglet performance after weaning","volume":"11","author":"Mereu","year":"2015","journal-title":"BMC Vet. Res."},{"key":"2024022318564974600_CIT0048","doi-asserted-by":"crossref","first-page":"999","DOI":"10.2527\/jas.2014-8616","article-title":"Body composition and plasma lipid and stress hormone levels during 3 weeks of feed restriction and refeeding in low birth weight female pigs","volume":"93","author":"Metges","year":"2015","journal-title":"J. Anim. Sci."},{"key":"2024022318564974600_CIT0049","doi-asserted-by":"crossref","first-page":"G173","DOI":"10.1152\/ajpgi.00197.2006","article-title":"Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig","volume":"292","author":"Moeser","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2024022318564974600_CIT0050","doi-asserted-by":"crossref","first-page":"G413","DOI":"10.1152\/ajpgi.00304.2006","article-title":"Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs","volume":"293","author":"Moeser","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2024022318564974600_CIT0051","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2141\/jpsa.0190004","article-title":"Heat stress directly affects intestinal integrity in broiler chickens","volume":"57","author":"Nanto-Hara","year":"2020","journal-title":"J. Poult. Sci."},{"key":"2024022318564974600_CIT0052","volume-title":"Nutrient requirements of swine","author":"NRC","year":"2012","edition":"11th rev. ed"},{"key":"2024022318564974600_CIT0053","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3382\/ps.0650570","article-title":"Effects of thermal-induced respiratory alkalosis on blood ionized calcium levels in the domestic hen","volume":"65","author":"Odom","year":"1986","journal-title":"Poult. Sci."},{"key":"2024022318564974600_CIT0054","doi-asserted-by":"crossref","first-page":"e39935","DOI":"10.1371\/journal.pone.0039935","article-title":"CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-\u03b1","volume":"7","author":"Overman","year":"2012","journal-title":"PLoS One."},{"key":"2024022318564974600_CIT0055","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S1471-4906(03)00173-X","article-title":"How stress influences the immune response","volume":"24","author":"Padgett","year":"2003","journal-title":"Trends Immunol."},{"key":"2024022318564974600_CIT0056","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.2527\/jas.2013-6759","article-title":"Heat stress and reduced plane of nutrition decreases intestinal integrity and function in pigs","volume":"91","author":"Pearce","year":"2013","journal-title":"J. Anim. Sci."},{"key":"2024022318564974600_CIT0057","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.2527\/jas.2014-8407","article-title":"Short term exposure to HS attenuates appetite and intestinal integrity in growing pigs","volume":"92","author":"Pearce","year":"2014","journal-title":"J. Anim. Sci."},{"key":"2024022318564974600_CIT0058","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.2527\/jas.2015-9018","article-title":"Dietary organic zinc attenuates heat stress-induced changes in pig intestinal integrity and metabolism","volume":"93","author":"Pearce","year":"2015","journal-title":"J. Anim. Sci."},{"key":"2024022318564974600_CIT0059","doi-asserted-by":"crossref","first-page":"e13118","DOI":"10.1111\/nmo.13118","article-title":"Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity","volume":"29","author":"Pohl","year":"2017","journal-title":"Neurogastroenterol. Motil."},{"key":"2024022318564974600_CIT0060","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.imbio.2015.11.003","article-title":"Mast cells and histamine alter intestinal permeability during malaria parasite infection","volume":"221","author":"Potts","year":"2016","journal-title":"Immunobiology"},{"key":"2024022318564974600_CIT0061","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0301-6226(97)00137-1","article-title":"Influence of high ambient temperature on performance of reproductive sows","volume":"52","author":"Prunier","year":"1997","journal-title":"Livest. Prod. Sci."},{"key":"2024022318564974600_CIT0062","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000237129","article-title":"Mucosal histamine content and histamine secretion in Crohn\u2019s disease, ulcerative colitis, and allergic enteropathy","volume":"108","author":"Raithel","year":"1995","journal-title":"Int. Arch. Allergy Immunol."},{"key":"2024022318564974600_CIT0063","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1071\/AN15267","article-title":"Physiological consequences of heat stress in pigs","volume":"55","author":"Ross","year":"2015","journal-title":"Anim. Prod. Sci."},{"key":"2024022318564974600_CIT0064","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00436-007-0591-y","article-title":"Immune response and inhibitory effect of ketotifen on the BALB\/c and C3H\/HeN mice infected with Echinostoma hortense","volume":"101","author":"Ryang","year":"2007","journal-title":"Parasitol. 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