{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:07:03Z","timestamp":1791925623593,"version":"4.3.4"},"reference-count":73,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":59,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Two experiments were conducted using 120 pigs to test the hypothesis that supplementation of \u03b2-mannanase could reduce digesta viscosity, enhance nutrient digestion, and improve intestinal health and growth of nursery pigs. In experiment 1, 48 crossbred barrows were randomly allotted to four treatments with increasing levels of \u03b2-mannanase at 0, 200, 400, and 600 U\/kg in feeds. All pigs were euthanized on day 12 to collect jejunal digesta to measure digesta viscosity and ileal digesta to measure apparent ileal digestibility (AID) of dry matter (DM), gross energy (GE), neutral detergent fiber (NDF), and acid detergent fiber (ADF). In experiment 2, 72 nursery pigs were randomly allotted to three treatments with increasing levels of \u03b2-mannanase at 0, 400, and 600 U\/kg in feeds. Plasma collected on day 9 was used to measure tumor necrosis factor-\u03b1 (TNF-\u03b1), immunoglobulin G (IgG), malondialdehyde (MDA), and protein carbonyl (PC). All pigs were euthanized on day 10 to collect duodenal and jejunal tissues to evaluate the production of TNF-\u03b1, IL-6, and MDA, morphology, crypt cell proliferation, and expression of tight junction proteins in the jejunum. Data were analyzed using the MIXED procedure for polynomial contrasts and the NLMIXED procedure for broken-line analysis of SAS. In experiment 1, \u03b2-mannanase supplementation tended to have quadratic effects on digesta viscosity (P\u2005=\u20050.085) and AID of GE (P\u2005=\u20050.093) in the pigs. In experiment 2, jejunal digesta viscosity of the pigs was reduced (P\u2005&amp;lt;\u20050.05) when \u03b2-mannanase was supplemented at 360 U\/kg of feed. \u03b2-Mannanase supplementation linearly reduced (P\u2005&amp;lt;\u20050.05) TNF-\u03b1, IgG, MDA, and PC in the duodenum, and TNF-\u03b1, IgG, and MDA in the jejunum of the pigs. \u03b2-Mannanase supplementation linearly increased (P\u2005&amp;lt;\u20050.05) villus height to crypt depth ratio and crypt cell proliferation in the jejunum. \u03b2-Mannanase supplementation tended to linearly improve (P\u2005=\u20050.083) expression of zonula occludens-1 in the jejunum. In conclusion, supplementation of \u03b2-mannanase at 360 U\/kg reduced the digesta viscosity and up to 600 U\/kg positively affected intestinal health and growth of pigs by reducing inflammation and oxidative stress whilst enhancing structure and barrier function in the jejunum.<\/jats:p>","DOI":"10.1093\/jas\/skae052","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T01:02:09Z","timestamp":1708995729000},"source":"Crossref","is-referenced-by-count":27,"title":["Effects of \u03b2-mannanase supplementation on intestinal health and growth of nursery pigs"],"prefix":"10.1093","volume":"102","author":[{"given":"Ki Beom","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ihn","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0094-336X","authenticated-orcid":false,"given":"Marcos Elias","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-1943","authenticated-orcid":false,"given":"Sung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"2024032119132644100_CIT0001","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.3390\/ani10081283","article-title":"Dietary mannan oligosaccharides modulate gut inflammatory response and improve duodenal villi height in post-weaning piglets improving feed efficiency","volume":"10","author":"Agazzi","year":"2020","journal-title":"Animals"},{"key":"2024032119132644100_CIT0002","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1111\/pce.13560","article-title":"Dynamics of intracellular mannan and cell wall folding in the drought responses of succulent Aloe species","volume":"42","author":"Ahl","year":"2019","journal-title":"Plant Cell Environ"},{"key":"2024032119132644100_CIT0003","volume-title":"Official methods of analysis of AOAC International","author":"AOAC","year":"2006"},{"key":"2024032119132644100_CIT0004","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fvets.2015.00044","article-title":"Immunometabolism and the kinome peptide array: a new perspective and tool for the study of gut health","volume":"2","author":"Arsenault","year":"2015","journal-title":"Front. Vet. Sci"},{"key":"2024032119132644100_CIT0005","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.3382\/ps\/pex246","article-title":"Changes in immune and metabolic gut response in broilers fed \u03b2-mannanase in \u03b2-mannan-containing diets","volume":"96","author":"Arsenault","year":"2017","journal-title":"Poult. Sci"},{"key":"2024032119132644100_CIT0006","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3390\/ani11030609","article-title":"Friend or foe? Impacts of dietary xylans, xylooligosaccharides, and xylanases on intestinal health and growth performance of monogastric animals","volume":"11","author":"Baker","year":"2021","journal-title":"Animals"},{"key":"2024032119132644100_CIT0007","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.3382\/ps\/pey157","article-title":"Inclusion of dietary \u03b2-mannanase improves performance and ileal digestibility and reduces ileal digesta viscosity of broilers fed corn-soybean meal based diet","volume":"97","author":"Balasubramanian","year":"2018","journal-title":"Poult. Sci"},{"key":"2024032119132644100_CIT0008","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1104\/pp.110.158642","article-title":"Seed cell wall storage polysaccharides: models to understand cell wall biosynthesis and degradation","volume":"154","author":"Buckeridge","year":"2010","journal-title":"Plant Physiol"},{"key":"2024032119132644100_CIT0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-313X.1993.tb00007.x","article-title":"Structural models of primary cell walls in flowering plants: consistency of molecular structure with the physical properties of the walls during growth","volume":"3","author":"Carpita","year":"1993","journal-title":"Plant J"},{"key":"2024032119132644100_CIT0010","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.aninu.2017.09.005","article-title":"Impacts of energy feeds and supplemental protease on growth performance, nutrient digestibility, and gut health of pigs from 18 to 45\u00a0kg body weight","volume":"3","author":"Chen","year":"2017","journal-title":"Anim. Nutr"},{"key":"2024032119132644100_CIT0011","doi-asserted-by":"crossref","first-page":"skaa185","DOI":"10.1093\/jas\/skaa185","article-title":"Effects of supplemental xylanase on gut health and growth performance of nursery pigs fed diets with corn distillers\u2019 dried grains with solubles","volume":"98","author":"Chen","year":"2020","journal-title":"J. Anim. Sci"},{"key":"2024032119132644100_CIT0012","doi-asserted-by":"crossref","first-page":"skad116","DOI":"10.1093\/jas\/skad116","article-title":"Comparative effects of benzoic acid and sodium benzoate in diets for nursery pigs on growth performance and acidification of digesta and urine","volume":"101","author":"Choi","year":"2023","journal-title":"J. Anim. Sci"},{"key":"2024032119132644100_CIT0013","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/nrm1746","article-title":"Growth of the plant cell wall","volume":"6","author":"Cosgrove","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"2024032119132644100_CIT0014","doi-asserted-by":"crossref","first-page":"skac255","DOI":"10.1093\/jas\/skac255","article-title":"Soy protein concentrate replacing animal protein supplements and its impacts on intestinal immune status, intestinal oxidative stress status, nutrient digestibility, mucosa-associated microbiota, and growth performance of nursery pigs","volume":"100","author":"Deng","year":"2022","journal-title":"J. Anim. Sci"},{"key":"2024032119132644100_CIT0015","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3390\/toxins15070433","article-title":"Efficacy of feed additive containing bentonite and enzymatically hydrolyzed yeast on intestinal health and growth of newly weaned pigs under chronic dietary challenges of fumonisin and aflatoxin","volume":"15","author":"Deng","year":"2023","journal-title":"Toxins (Basel)"},{"key":"2024032119132644100_CIT0016","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.aninu.2023.06.007","article-title":"Efficacy of soy protein concentrate replacing animal protein supplements in mucosa-associated microbiota, intestinal health, and growth performance of nursery pigs","volume":"14","author":"Deng","year":"2023","journal-title":"Anim. Nutr"},{"key":"2024032119132644100_CIT0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jas\/skab190","article-title":"Modulation of jejunal mucosa-associated microbiota in relation to nutrient digestibility and intestinal health of pigs by supplementation of \u03b2-glucanase to corn soybean meal-based diets with xylanase","volume":"99","author":"Duarte","year":"2021","journal-title":"J. Anim. Sci"},{"key":"2024032119132644100_CIT0018","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.3390\/antiox11102066","article-title":"Phytobiotics from oregano extracts enhance the intestinal health and growth performance of pigs","volume":"11","author":"Duarte","year":"2022","journal-title":"Antioxidants"},{"key":"2024032119132644100_CIT0020","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.aninu.2019.04.005","article-title":"Dietary supplementation of xylanase and protease on growth performance, digesta viscosity, nutrient digestibility, immune and oxidative stress status, and gut health of newly weaned pigs","volume":"5","author":"Duarte","year":"2019","journal-title":"Anim. Nutr"},{"key":"2024032119132644100_CIT0021","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.3390\/antiox12051040","article-title":"Intestinal oxidative damages by F18+ Escherichia coli and its amelioration with an antibacterial bacitracin fed to nursery pigs","volume":"12","author":"Duarte","year":"2023","journal-title":"Antioxidants"},{"key":"2024032119132644100_CIT0022","article-title":"Chapter 9: Swine","volume-title":"Guide for the care and use of agricultural animals in research and teaching. Ag Guide","author":"Federation of Animal Science Societies","year":"2020","edition":"4th ed"},{"key":"2024032119132644100_CIT0023","doi-asserted-by":"crossref","first-page":"skaa097","DOI":"10.1093\/jas\/skaa097","article-title":"Impact of dietary oxidized protein on oxidative status and performance in growing pigs","volume":"98","author":"Frame","year":"2020","journal-title":"J. Anim. Sci"},{"key":"2024032119132644100_CIT0024","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3389\/fvets.2023.1144692","article-title":"\u03b2-Mannanase supplementation in diets reduced in 85 kcal metabolizable energy\/kg containing xylanase-phytase improves gain to feed ratio, nutrient usage, and backfat thickness in finisher pigs","volume":"10","author":"Genova","year":"2023","journal-title":"Front. Vet. Sci"},{"key":"2024032119132644100_CIT0025","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3390\/ani2020261","article-title":"Mannan oligosaccharides in nursery pig nutrition and their potential mode of action","volume":"2","author":"Halas","year":"2012","journal-title":"Animals"},{"key":"2024032119132644100_CIT0026","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40104-022-00691-6","article-title":"Impacts of weaning weights and mycotoxin challenges on jejunal mucosa-associated microbiota, intestinal and systemic health, and growth performance of nursery pigs","volume":"13","author":"Holanda","year":"2022","journal-title":"J. Anim. Sci. Biotechnol"},{"key":"2024032119132644100_CIT0027","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1089\/jmf.2004.7.430","article-title":"Aspergillus oryzae GB-107 fermentation improves nutritional quality of food soybeans and feed soybean meals","volume":"7","author":"Hong","year":"2004","journal-title":"J. Med. Food"},{"key":"2024032119132644100_CIT0028","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.2527\/1997.7561443x","article-title":"Feed intake pattern of group-housed growing-finishing pigs monitored using a computerized feed intake recording system","volume":"75","author":"Hyun","year":"1997","journal-title":"J. Anim. Sci"},{"key":"2024032119132644100_CIT0029","doi-asserted-by":"crossref","first-page":"670817","DOI":"10.3389\/fnut.2021.670817","article-title":"Hemicellulose-derived oligosaccharides: emerging prebiotics in disease alleviation","volume":"8","author":"Jana","year":"2021","journal-title":"Front. Nutr"},{"key":"2024032119132644100_CIT0030","author":"Jang","year":"2022"},{"key":"2024032119132644100_CIT0031","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40104-021-00650-7","article-title":"Role of milk carbohydrates in intestinal health of nursery pigs: a review","volume":"13","author":"Jang","year":"2022","journal-title":"J. Anim. Sci. Biotechnol"},{"key":"2024032119132644100_CIT0077","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jas\/skaa271","article-title":"Effects of mineral methionine hydroxy analog chelate in sow diets on epigenetic modification and growth of progeny","volume":"98","author":"Jang","year":"2020","journal-title":"J. Anim. Sci"},{"key":"2024032119132644100_CIT0035","doi-asserted-by":"crossref","first-page":"skab008","DOI":"10.1093\/jas\/skab008","article-title":"Dose\u2013response and functional role of whey permeate as a source of lactose and milk oligosaccharides on intestinal health and growth of nursery pigs","volume":"99","author":"Jang","year":"2021","journal-title":"J. Anim. Sci"},{"key":"2024032119132644100_CIT0036","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.5713\/ab.23.0158","article-title":"Effects of bacterial \u03b2-mannanase on apparent total tract digestibility of nutrients in various feedstuffs fed to growing pigs","volume":"36","author":"Jang","year":"2023","journal-title":"Anim. Biosci"},{"key":"2024032119132644100_CIT0037","first-page":"1","article-title":"Efficacy of zinc glycinate reducing zinc oxide on intestinal health and growth of nursery pigs challenged with F18 + Escherichia coli","volume":"101","author":"Jang","year":"2023","journal-title":"J. Anim. Sci"},{"key":"2024032119132644100_CIT0038","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.aninu.2019.07.001","article-title":"Comparative standardized ileal amino acid digestibility and metabolizable energy contents of main feed ingredients for growing pigs when adding dietary \u03b2-mannanase","volume":"5","author":"Jeon","year":"2019","journal-title":"Anim. Nutr"},{"key":"2024032119132644100_CIT0039","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40104-021-00576-0","article-title":"Dietary fiber in poultry nutrition and their effects on nutrient utilization, performance, gut health, and on the environment: a review","volume":"12","author":"Jha","year":"2021","journal-title":"J. Anim. Sci. Biotechnol"},{"key":"2024032119132644100_CIT0040","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1021\/ja01868a059","article-title":"The viscous flow of large molecules","volume":"62","author":"Kauzmann","year":"1940","journal-title":"J. Am. Chem. Soc"},{"key":"2024032119132644100_CIT0041","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1017\/S0954422413000048","article-title":"The role of added feed enzymes in promoting gut health in swine and poultry","volume":"26","author":"Kiarie","year":"2013","journal-title":"Nutr. Res. Rev"},{"key":"2024032119132644100_CIT0042","doi-asserted-by":"crossref","first-page":"txab160","DOI":"10.1093\/tas\/txab160","article-title":"Significance of single \u03b2-mannanase supplementation on performance and energy utilization in broiler chickens, laying hens, turkeys, sows, and nursery-finish pigs: a meta-analysis and systematic review","volume":"5","author":"Kiarie","year":"2021","journal-title":"Transl. Anim. Sci"},{"key":"2024032119132644100_CIT0043","doi-asserted-by":"crossref","first-page":"875095","DOI":"10.3389\/fanim.2022.875095","article-title":"Does supplementing \u03b2-mannanase modulate the feed-induced immune response and gastrointestinal ecology in poultry and pigs? An appraisal","volume":"3","author":"Kiarie","year":"2022","journal-title":"Front. Anim. Sci"},{"key":"2024032119132644100_CIT0044","doi-asserted-by":"crossref","first-page":"338","DOI":"10.5713\/ab.21.0010","article-title":"Understanding intestinal health in nursery pigs and the relevant nutritional strategies","volume":"34","author":"Kim","year":"2021","journal-title":"Anim. Biosci"},{"key":"2024032119132644100_CIT0045","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2527\/jas.2009-1993","article-title":"Fermented soybean meal as a vegetable protein source for nursery pigs: I. Effects on growth performance of nursery pigs","volume":"88","author":"Kim","year":"2010","journal-title":"J. Anim. Sci"},{"key":"2024032119132644100_CIT0046","first-page":"399","article-title":"Effects of supplemental \u03b2-mannanase to provide substrates for binding to aflatoxin in feed on growth and health of pigs","author":"Kim","year":"2016"},{"key":"2024032119132644100_CIT0047","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1017\/S1751731116001385","article-title":"Effects of mannan level and \u03b2-mannanase supplementation on growth performance, apparent total tract digestibility and blood metabolites of growing pigs","volume":"11","author":"Kim","year":"2017","journal-title":"Animal"},{"key":"2024032119132644100_CIT0048","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3390\/toxins11110633","article-title":"Efficacy of a yeast cell wall extract to mitigate the effect of naturally co-occurring mycotoxins contaminating feed ingredients fed to young pigs: impact on gut health, microbiome, and growth","volume":"11","author":"Kim","year":"2019","journal-title":"Toxins"},{"key":"2024032119132644100_CIT0049","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1271\/bbb.61.1866","article-title":"Structural analysis of N-glycans of storage glycoproteins in soybean (Glycine max L) seed","volume":"61","author":"Kimura","year":"1997","journal-title":"Biosci. Biotechnol. Biochem"},{"key":"2024032119132644100_CIT0050","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1080\/00021369.1966.10858660","article-title":"Carbohydrate component in 7S protein of soybean casein fraction","volume":"30","author":"Koshiyama","year":"1966","journal-title":"Agric. Biol. Chem"},{"key":"2024032119132644100_CIT0051","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1017\/S0029665107005484","article-title":"Nutritional management of gut health in pigs around weaning","volume":"66","author":"Lall\u00e8s","year":"2007","journal-title":"Proc. Nutr. Soc"},{"key":"2024032119132644100_CIT0052","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.2527\/1990.6861790x","article-title":"Transient hypersensitivity to soybean meal in the early-weaned pig","volume":"68","author":"Li","year":"1990","journal-title":"J. Anim. Sci"},{"key":"2024032119132644100_CIT0053","doi-asserted-by":"crossref","first-page":"1010221","DOI":"10.3389\/fimmu.2022.1010221","article-title":"Dietary mannan oligosaccharides strengthens intestinal immune barrier function via multipath cooperation during aeromonas hydrophila infection in grass carp (Ctenopharyngodon idella)","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Immunol"},{"key":"2024032119132644100_CIT0054","doi-asserted-by":"crossref","first-page":"579","DOI":"10.5713\/ajas.2012.12612","article-title":"Effects of supplementation of \u03b2-mannanase in corn-soybean meal diets on performance and nutrient digestibility in growing pigs","volume":"26","author":"Lv","year":"2013","journal-title":"Asian Australas. J. Anim. Sci"},{"key":"2024032119132644100_CIT0055","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.3390\/nu14214699","article-title":"Direct action of non-digestible oligosaccharides against a leaky gut","volume":"14","author":"Mavrogeni","year":"2022","journal-title":"Nutrients"},{"key":"2024032119132644100_CIT0056","doi-asserted-by":"crossref","first-page":"24855","DOI":"10.1074\/jbc.C200240200","article-title":"Zonula occludens-1 is a scaffolding protein for signaling molecules. Galpha(12) directly binds to the Src homology 3 domain and regulates paracellular permeability in epithelial cells","volume":"277","author":"Meyer","year":"2022","journal-title":"J. Biol. Chem"},{"key":"2024032119132644100_CIT0057","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.3390\/ani12233322","article-title":"Nutritional and functional roles of phytase and xylanase enhancing the intestinal health of nursery pigs and broiler chickens","volume":"12","author":"Moita","year":"2022","journal-title":"Animals"},{"key":"2024032119132644100_CIT0058","doi-asserted-by":"crossref","first-page":"skad134","DOI":"10.1093\/jas\/skad134","article-title":"Efficacy of a bacterial 6-phytase supplemented beyond traditional dose levels on jejunal mucosa-associated microbiota, ileal nutrient digestibility, bone and intestinal health, and growth performance of nursery pigs","volume":"101","author":"Moita","year":"2023","journal-title":"J. Anim. Sci"},{"key":"2024032119132644100_CIT0059","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jas\/skac116","article-title":"Functional roles of xylanase enhancing intestinal health and growth performance of nursery pigs by reducing the digesta viscosity and modulating the mucosa-associated microbiota in the jejunum","volume":"100","author":"Moita","year":"2022","journal-title":"J. Anim. Sci"},{"key":"2024032119132644100_CIT0060","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1439-0396.2008.00835.x","article-title":"Effect of different levels of mannan-oligosaccharide supplementation on some immunological variables in weaned piglets","volume":"93","author":"Nochta","year":"2009","journal-title":"J. Anim. Physiol. Anim. Nutr"},{"key":"2024032119132644100_CIT0061","volume-title":"Nutrient requirements of swine: 11th revised edition","author":"NRC","year":"2012"},{"key":"2024032119132644100_CIT0062","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4141\/A04-001","article-title":"Voluntary feed intake in growing-finishing pigs: a review of the main determining factors and potential approaches for accurate predictions","volume":"84","author":"Nyachoti","year":"2004","journal-title":"Can. J. Anim. Sci"},{"key":"2024032119132644100_CIT0063","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.2527\/jas.2014-8435","article-title":"Nutrient value of spray field forages fed to pigs and the use of fibrolytic enzymes to enhance nutrient digestibility","volume":"93","author":"Passos","year":"2015","journal-title":"J. Anim. Sci"},{"key":"2024032119132644100_CIT0064","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.aninu.2015.02.006","article-title":"Effect of dietary supplementation of xylanase on apparent ileal digestibility of nutrients, viscosity of digesta, and intestinal morphology of growing pigs fed corn and soybean meal based diet","volume":"1","author":"Passos","year":"2015","journal-title":"Anim. Nutr"},{"key":"2024032119132644100_CIT0065","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/asj.12319","article-title":"Effects of fermented soybean meal on innate immunity-related gene expressions in nursery pigs acutely challenged with lipopolysaccharides","volume":"86","author":"Roh","year":"2015","journal-title":"Anim. Sci. J"},{"key":"2024032119132644100_CIT0066","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-arplant-042809-112315","article-title":"Hemicelluloses","volume":"61","author":"Scheller","year":"2010","journal-title":"Annu. Rev. Plant Biol"},{"key":"2024032119132644100_CIT0067","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.anifeedsci.2018.07.002","article-title":"Supplemental effect of xylanase and mannanase on nutrient digestibility and gut health of nursery pigs studied using both in vivo and in vitro model","volume":"245","author":"Tiwari","year":"2018","journal-title":"Anim. Feed Sci. Technol"},{"key":"2024032119132644100_CIT0068","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1080\/17474124.2017.1343143","article-title":"The intestinal barrier: a fundamental role in health and disease","volume":"11","author":"Vancamelbeke","year":"2017","journal-title":"Expert Rev. Gastroenterol. Hepatol"},{"key":"2024032119132644100_CIT0069","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.3168\/jds.S0022-0302(91)78551-2","article-title":"Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition","volume":"74","author":"Van Soest","year":"1991","journal-title":"J. Dairy Sci"},{"key":"2024032119132644100_CIT0070","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1017\/S002185960001546X","article-title":"The determination of chromic oxide in faeces samples by atomic absorption spectrophotometry","volume":"59","author":"Williams","year":"1962","journal-title":"J. Agric. Sci"},{"key":"2024032119132644100_CIT0071","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1177\/0300985814559404","article-title":"Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip","volume":"52","author":"Williams","year":"2015","journal-title":"Vet. Pathol"},{"key":"2024032119132644100_CIT0072","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1139\/w05-033","article-title":"A mannanase, ManA, of the polycentric anaerobic fungus Orpinomyces sp. strain PC-2 has carbohydrate binding and docking modules","volume":"51","author":"Ximenes","year":"2005","journal-title":"Can. J. Microbiol"},{"key":"2024032119132644100_CIT0073","doi-asserted-by":"crossref","first-page":"795081","DOI":"10.3389\/fmicb.2021.795081","article-title":"Supplementing mannan oligosaccharide reduces the passive transfer of immunoglobulin g and improves antioxidative capacity, immunity, and intestinal microbiota in neonatal goats","volume":"12","author":"Yang","year":"2021","journal-title":"Front. Microbiol"},{"key":"2024032119132644100_CIT0074","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2527\/jas.2008-1741","article-title":"Effects of mannanase and distillers dried grain with solubles on growth performance, nutrient digestibility, and carcass characteristics of grower-finisher pigs","volume":"88","author":"Yoon","year":"2010","journal-title":"J. Anim. Sci"},{"key":"2024032119132644100_CIT0075","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fvets.2021.628258","article-title":"Intestinal health of pigs upon weaning: challenges and nutritional intervention","volume":"8","author":"Zheng","year":"2021","journal-title":"Front. Vet. Sci"},{"key":"2024032119132644100_CIT0076","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3390\/ani9100817","article-title":"Effects of mannanoligosaccharide supplementation on the growth performance, immunity, and oxidative status of partridge shank chickens","volume":"9","author":"Zhou","year":"2019","journal-title":"Animals"}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jas\/advance-article-pdf\/doi\/10.1093\/jas\/skae052\/56798111\/skae052.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/doi\/10.1093\/jas\/skae052\/57052166\/skae052.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/doi\/10.1093\/jas\/skae052\/57052166\/skae052.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T15:15:23Z","timestamp":1711034123000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/doi\/10.1093\/jas\/skae052\/7616444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,1]]},"references-count":73,"URL":"https:\/\/doi.org\/10.1093\/jas\/skae052","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1,1]]},"published":{"date-parts":[[2024,1,1]]},"article-number":"skae052"}}