{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:09:05Z","timestamp":1787062145358,"version":"build-2736575974"},"reference-count":41,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":119,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vitamin E (VE) is a potent nutritional antioxidant that is critical in alleviating poultry oxidative stress. However, the hydrophobic nature and limited stability of VE restrict its effective utilization. Nanotechnology offers a promising approach to enhance the bioavailability of lipophilic vitamins. The objective of this experiment was to investigate the effects of different sources and addition levels of VE on the growth performance, antioxidant capacity, VE absorption site, and pharmacokinetics of Arbor Acres (AA) broilers. Three hundred and eighty-four 1-d-old AA chicks were randomly allocated into four groups supplemented with 30 and 75 IU\/kg VE as regular or nano. The results showed that dietary VE sources had no significant impact on broiler growth performance. However, chickens fed 30 IU\/kg VE had a higher average daily gain at 22 to 42 d and 1 to 42 d, and lower feed conversion ratio at 22 to 42 d than 75 IU\/kg VE (P\u2005&amp;lt;\u20050.05). Under normal feeding conditions, broilers fed nano VE (NVE) displayed significantly higher superoxide dismutase (SOD) activity and glutathione peroxidase (GSH-Px) enzyme activities and lower malonic dialdehyde (MDA) concentration (P\u2005&amp;lt;\u20050.05). Similarly, NVE had a higher antioxidant effect in the dexamethasone-constructed oxidative stress model. It was found that nanosizing technology had no significant effect on the absorption of VE in the intestinal tract by examining the concentration of VE in the intestinal tract (P\u2005&amp;gt;\u20050.05). However, compared to broilers perfused with regular VE (RVE), the NVE group displayed notably higher absorption rates at 11.5 and 14.5\u00a0h (P\u2005&amp;lt;\u20050.05). Additionally, broilers perfused with NVE showed a significant increase in the area under the concentration versus time curve from zero to infinity (AUC0\u2212\u221e), mean residence time (MRT0\u2212\u221e), elimination half-life (t1\/2z), and peak concentration (Cmax) of VE in plasma (P\u2005&amp;lt;\u20050.05). In summary, nanotechnology provides more effective absorption and persistence of VE in the blood circulation for broilers, which is conducive to the function of VE and further improves the antioxidant performance of broilers.<\/jats:p>","DOI":"10.1093\/jas\/skae095","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T15:36:09Z","timestamp":1714232169000},"source":"Crossref","is-referenced-by-count":16,"title":["Nano vitamin E improved the antioxidant capacity of broiler chickens"],"prefix":"10.1093","volume":"102","author":[{"given":"Jinghui","family":"Zhou","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&F University , Yangling 712100 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&F University , Yangling 712100 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&F University , Yangling 712100 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&F University , Yangling 712100 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&F University , Yangling 712100 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhuo","family":"Huang","sequence":"additional","affiliation":[{"name":"Nano Vitamin Engineering Research Center , Xi\u2019an 710000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingge","family":"Li","sequence":"additional","affiliation":[{"name":"Shaanxi Province Animal Husbandry Technology Extension Station , Xi\u2019an 710000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&F University , Yangling 712100 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Massachusetts Amherst , Amherst, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&F University , Yangling 712100 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiurong","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&F University , Yangling 712100 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"2024050612255304700_CIT0001","doi-asserted-by":"crossref","first-page":"736804","DOI":"10.1016\/j.aquaculture.2021.736804","article-title":"Chitosan vitamin E nanocomposite ameliorates the growth, redox, and immune status of Nile tilapia (Oreochromis niloticus) reared under different stocking densities","volume":"541","author":"Ahmed","year":"2021","journal-title":"Aquaculture"},{"key":"2024050612255304700_CIT0002","doi-asserted-by":"crossref","first-page":"775311","DOI":"10.3389\/fanim.2021.775311","article-title":"Environmental stress in chickens and the potential effectiveness of dietary vitamin supplementation","volume":"2","author":"Akinyemi","year":"2021","journal-title":"Front. 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