{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T23:39:18Z","timestamp":1786318758234,"version":"build-2736575974"},"reference-count":41,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study evaluated if vasoactive intestinal polypeptide (VIP) influences growth performance, nutrient digestibility, nitrogen balance, and digestive enzyme activity. Sixteen wether lambs (69.6\u2005\u00b1\u20051.9\u00a0kg) were housed in individual pens, adapted to a corn grain-based diet, and randomly assigned to 2 treatment groups. Lambs were injected intraperitoneally every other day for 28 d with saline (0.9% NaCl) containing no VIP (n\u2005=\u20058; control) or containing VIP (n\u2005=\u20058; 1.3 nmol\/kg body weight [BW]). All lambs were transferred to individual metabolic crates for the final 7 d of the experiment to measure nitrogen balance and nutrient digestibility. At the end of the treatment period, lambs were slaughtered, and pancreatic tissue, small intestinal tissue, and rumen fluid were collected for protein, digestive enzymes, ruminal pH, and volatile fatty acid (VFA) analyses. Lambs treated with VIP had greater final BW, average daily gain, and gain:feed (P\u2005=\u20050.01, 0.05, 0.03, respectively). No differences between treatment groups were observed (P\u2005\u2265\u20050.25) for nutrient intake, digestibility, nitrogen retention, ruminal pH, and VFA concentrations. Moreover, VIP treatment did not influence (P\u2005\u2265\u20050.19) plasma glucose, urea N, and insulin concentrations. Treatment with VIP increased (P\u2005=\u20050.03) relative cecum weight (g\/kg BW) and decreased (P\u2005=\u20050.05) relative brain weight. Pancreatic and intestinal digestive enzyme activities, except for duodenal maltase (P\u2005=\u20050.02), were not influenced (P\u2005\u2265\u20050.09) by VIP treatment. These data suggest that the administration of VIP may have potential to improve average daily gain and gain:feed in lambs fed grain-based diets.<\/jats:p>","DOI":"10.1093\/jas\/skae112","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T03:27:14Z","timestamp":1713842834000},"source":"Crossref","is-referenced-by-count":4,"title":["Influence of vasoactive intestinal polypeptide on growth performance, nutrient digestibility, nitrogen balance, and digestive enzyme activity in lambs"],"prefix":"10.1093","volume":"102","author":[{"given":"Golam K","family":"Mia","sequence":"first","affiliation":[{"name":"Department of Animal Sciences, North Dakota State University , Fargo, ND 58108-6050 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7963-7199","authenticated-orcid":false,"given":"Emma","family":"Hawley","sequence":"additional","affiliation":[{"name":"Department of Microbiological Sciences, North Dakota State University , Fargo, ND 58108-6050 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, North Dakota State University , Fargo, ND 58108-6050 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Dorsam","sequence":"additional","affiliation":[{"name":"Department of Microbiological Sciences, North Dakota State University , Fargo, ND 58108-6050 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5694-4778","authenticated-orcid":false,"given":"Kendall C","family":"Swanson","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, North Dakota State University , Fargo, ND 58108-6050 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"2024050714463673900_CIT0001","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1053\/gast.2003.50141","article-title":"Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn\u2019s disease","volume":"124","author":"Abad","year":"2003","journal-title":"Gastroenterology"},{"key":"2024050714463673900_CIT0002","volume-title":"Official methods of analysis","author":"Association of Official Analytical Chemists (AOAC)","year":"1990","edition":"15th ed."},{"key":"2024050714463673900_CIT0003","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.peptides.2008.01.019","article-title":"VIP balances innate and adaptive immune responses induced by specific stimulation of TLR2 and TLR4","volume":"29","author":"Arranz","year":"2008","journal-title":"Peptides"},{"key":"2024050714463673900_CIT0004","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.3389\/fmicb.2019.02689","article-title":"Vasoactive intestinal peptide deficiency is associated with altered gut microbiota communities in male and female C57BL\/6 mice","volume":"10","author":"Bains","year":"2019","journal-title":"Front. 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