{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:40:33Z","timestamp":1790199633871,"version":"4.1.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The mechanistic target of rapamycin (mTOR) cell signaling pathway serves as the central mechanism for the regulation of tissue protein synthesis and growth. We recently reported that supplementing 1% glycine to corn- and soybean meal-based diets enhanced growth performance between weaning and market weights in pigs with intrauterine growth restriction (IUGR). Results of recent studies have revealed an important role for glycine in activating mTOR and protein synthesis in C2C12 muscle cells. Therefore, the present study tested the hypothesis that dietary glycine supplementation enhanced the mTOR cell signaling pathway in skeletal muscle and other tissues of IUGR pigs. At weaning (21 d of age), IUGR pigs and litter mates with normal birth weights (NBW) were assigned randomly to one of the two groups: supplementation with either 1% glycine or 1.19% l-alanine (isonitrogenous control) to a corn- and soybean meal-based diet. Tissues were obtained from the pigs within 1\u00a0wk after the feeding trial ended at 188 d of age to determine the abundances of total and phosphorylated forms of mTOR and its two major downstream proteins: eukaryotic initiation factor 4E-binding protein-1 (4EBP1) and ribosomal protein S6 kinase-1 (p70S6K). Results showed that IUGR decreased (P &amp;lt; 0.05) the abundances of both total and phosphorylated mTOR, 4EBP1, and p70S6K in the gastrocnemius muscle and jejunum. In the longissimus lumborum muscle of IUGR pigs, the abundances of total mTOR did not differ (P &amp;gt; 0.05) but those for phosphorylated mTOR and both total and phosphorylated 4EBP1 and p70S6K were downregulated (P &amp;lt; 0.05), when compared to NBW pigs. These adverse effects of IUGR in the gastrocnemius muscle, longissimus lumborum muscle, and jejunum were prevented (P &amp;lt; 0.05) by dietary glycine supplementation. Interestingly, the abundances of total or phosphorylated mTOR, 4EBP1, and p70S6K in the liver were not affected (P &amp;gt; 0.05) by IUGR or glycine supplementation. Collectively, our findings indicate that IUGR impaired the mTOR cell signaling pathway in the tissues of pigs and that adequate glycine intake was crucial for maintaining active mTOR-dependent protein synthesis for the growth and development of skeletal muscle.<\/jats:p>","DOI":"10.1093\/jas\/skae141","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T11:32:59Z","timestamp":1716031979000},"source":"Crossref","is-referenced-by-count":3,"title":["Dietary glycine supplementation activates mechanistic target of rapamycin signaling pathway in tissues of pigs with intrauterine growth restriction"],"prefix":"10.1093","volume":"102","author":[{"given":"Wenliang","family":"He","sequence":"first","affiliation":[{"name":"Texas A&M University Department of Animal Science, , College Station , TX 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin A","family":"Posey","sequence":"additional","affiliation":[{"name":"Texas A&M University Department of Animal Science, , College Station , TX 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandler C","family":"Steele","sequence":"additional","affiliation":[{"name":"Texas A&M University Department of Animal Science, , College Station , TX 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0354-1286","authenticated-orcid":false,"given":"Jeffrey W","family":"Savell","sequence":"additional","affiliation":[{"name":"Texas A&M University Department of Animal Science, , College Station , TX 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuller W","family":"Bazer","sequence":"additional","affiliation":[{"name":"Texas A&M University Department of Animal Science, , College Station , TX 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8058-6969","authenticated-orcid":false,"given":"Guoyao","family":"Wu","sequence":"additional","affiliation":[{"name":"Texas A&M University Department of Animal Science, , College Station , TX 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,18]]},"reference":[{"key":"2024070211375307000_CIT0001","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1210\/en.2013-1759","article-title":"Liver mTOR controls IGFI bioavailability by regulation of protein kinase CK2 and IGFBP1 phosphorylation in fetal growth restriction","volume":"155","author":"Abu Shehab","year":"2014","journal-title":"Endocrinology"},{"key":"2024070211375307000_CIT0002","first-page":"233","article-title":"Causes and consequences of fetal growth retardation in pigs","volume":"58","author":"Ashworth","year":"2001","journal-title":"Reprod. 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