{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:58:50Z","timestamp":1762300730005,"version":"3.41.2"},"reference-count":63,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":162,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Study objectives were to determine the effects of mitoquinol (MitoQ, a mitochondrial-targeted antioxidant) on biomarkers of metabolism and inflammation during acute heat stress (HS). Crossbred barrows [n\u2005=\u200532; 59.0\u2005\u00b1\u20055.6\u00a0kg body weight (BW)] were blocked by BW and randomly assigned to 1 of 4 environmental-therapeutic treatments: 1) thermoneutral (TN) control (n\u2005=\u20058; TNCon), 2) TN and MitoQ (n\u2005=\u20058; TNMitoQ), 3) HS control (n\u2005=\u20058; HSCon), or 4) HS and MitoQ (n\u2005=\u20058; HSMitoQ). Pigs were acclimated for 6 d to individual pens before study initiation. The trial consisted of two experimental periods (P). During P1 (2 d), pigs were fed ad libitum and housed in TN conditions (20.6\u2005\u00b1\u20050.8 \u00b0C). During P2 (24\u00a0h), HSCon and HSMitoQ pigs were exposed to continuous HS (35.2\u2005\u00b1\u20050.2 \u00b0C), while TNCon and TNMitoQ remained in TN conditions. MitoQ (40\u00a0mg\/d) was orally administered twice daily (0700 and 1800 hours) during P1 and P2. Pigs exposed to HS had increased rectal temperature, skin temperature, and respiration rate (+1.5 \u00b0C, +6.8 \u00b0C, and +101 breaths per minute, respectively; P\u2005&amp;lt;\u20050.01) compared to their TN counterparts. Acute HS markedly decreased feed intake (FI; 67%; P\u2005&amp;lt;\u20050.01); however, FI tended to be increased in HSMitoQ relative to HSCon pigs (1.5\u00a0kg vs. 0.9\u00a0kg, respectively; P\u2005=\u20050.08). Heat-stressed pigs lost BW compared to their TN counterparts (\u22124.7\u00a0kg vs. +1.6\u00a0kg, respectively; P\u2005&amp;lt;\u20050.01); however, the reduction in BW was attenuated in HSMitoQ compared to HSCon pigs (\u22123.9\u00a0kg vs. \u22125.5\u00a0kg, respectively; P\u2005&amp;lt;\u20050.01). Total gastrointestinal tract weight (empty tissue and luminal contents) was decreased in HS pigs relative to their TN counterparts (6.2\u00a0kg vs. 8.6\u00a0kg, respectively; P\u2005&amp;lt;\u20050.01). Blood glucose increased in HSMitoQ relative to HSCon pigs (15%; P\u2005=\u20050.04). Circulating non-esterified fatty acids (NEFA) increased in HS compared to TN pigs (P\u2005&amp;lt;\u20050.01), although this difference was disproportionately influenced by elevated NEFA in HSCon relative to HSMitoQ pigs (251 \u03bcEq\/L vs. 142 \u03bcEq\/L; P\u2005&amp;lt;\u20050.01). Heat-stressed pigs had decreased circulating insulin relative to their TN counterparts (47%; P\u2005=\u20050.04); however, the insulin:FI ratio tended to increase in HS relative to TN pigs (P\u2005=\u20050.09). Overall, circulating leukocytes were similar across treatments (P\u2005&amp;gt;\u20050.10). Plasma C-reactive protein remained similar among treatments; however, haptoglobin increased in HS relative to TN pigs (48%; P\u2005=\u20050.03). In conclusion, acute HS exposure negatively altered animal performance, inflammation, and metabolism, which were partially ameliorated by MitoQ.<\/jats:p>","DOI":"10.1093\/jas\/skae161","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T22:19:30Z","timestamp":1718057970000},"source":"Crossref","is-referenced-by-count":5,"title":["Therapeutic effects of mitoquinol during an acute heat stress challenge in growing barrows"],"prefix":"10.1093","volume":"102","author":[{"given":"Edith J","family":"Mayorga","sequence":"first","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin A","family":"Horst","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brady M","family":"Goetz","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Rodriguez-Jimenez","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan A","family":"Abeyta","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohmmad","family":"Al-Qaisi","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5205-5834","authenticated-orcid":false,"given":"Robert P","family":"Rhoads","sequence":"additional","affiliation":[{"name":"Department of Animal and Poultry Sciences, Virginia Tech , Blacksburg, VA 24061 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua T","family":"Selsby","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance H","family":"Baumgard","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"2024062710453469900_CIT0001","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.3168\/jds.2022-22338","article-title":"Effects of dietary antioxidant supplementation on metabolism and inflammatory biomarkers in heat-stressed dairy cows","volume":"106","author":"Abeyta","year":"2023","journal-title":"J. Dairy Sci"},{"key":"2024062710453469900_CIT0002","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1096\/fj.05-3718com","article-title":"Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury","volume":"19","author":"Adlam","year":"2005","journal-title":"FASEB J"},{"key":"2024062710453469900_CIT0003","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1080\/23328940.2016.1216255","article-title":"Heat stress and dehydration in adapting for performance: good, bad, both, or neither","volume":"3","author":"Akerman","year":"2016","journal-title":"Temperature (Austin)"},{"key":"2024062710453469900_CIT0004","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-animal-031412-103644","article-title":"Effects of heat stress on postabsorptive metabolism and energetics","volume":"1","author":"Baumgard","year":"2013","journal-title":"Annu. Rev. Anim. Biosci"},{"key":"2024062710453469900_CIT0005","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.3168\/jds.2021-21080","article-title":"Invited review: lethal heat stress: the putative pathophysiology of a deadly disorder in dairy cattle","volume":"105","author":"Burhans","year":"2022","journal-title":"J. Dairy Sci"},{"key":"2024062710453469900_CIT0006","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.2527\/jas.2014-7714","article-title":"Dietary antioxidants at supranutritional doses improve oxidative status and reduce the negative effects of heat stress in sheep","volume":"92","author":"Chauhan","year":"2014","journal-title":"J. Anim. Sci"},{"key":"2024062710453469900_CIT0007","doi-asserted-by":"crossref","first-page":"102415","DOI":"10.1016\/j.jtherbio.2019.102415","article-title":"Effects of resveratrol on intestinal oxidative status and inflammation in heat-stressed rats","volume":"85","author":"Cheng","year":"2019","journal-title":"J. Therm. Biol"},{"key":"2024062710453469900_CIT0008","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.3382\/ps\/pez192","article-title":"Dietary mannan oligosaccharide ameliorates cyclic heat stress-induced damages on intestinal oxidative status and barrier integrity of broilers","volume":"98","author":"Cheng","year":"2019","journal-title":"Poult. Sci"},{"key":"2024062710453469900_CIT0009","first-page":"517","article-title":"Acute phase response in animals: a review","volume":"59","author":"Cray","year":"2009","journal-title":"Comp. Med"},{"key":"2024062710453469900_CIT0010","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3390\/ani9070395","article-title":"Chronic heat stress induces acute phase responses and serum metabolome changes in finishing pigs","volume":"9","author":"Cui","year":"2019","journal-title":"Animals (Basel)"},{"key":"2024062710453469900_CIT0011","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.2174\/1381612823666170228142428","article-title":"Peripheral corticotropin releasing factor signaling inhibits gastric emptying: mechanisms of action and role in stress-related gastric alterations of motor function","volume":"23","author":"Czimmer","year":"2017","journal-title":"Curr. Pharm. Des"},{"key":"2024062710453469900_CIT0012","first-page":"169","volume-title":"Guide for care and use of agricultural animals in research and teaching","author":"FASS","year":"2010","edition":"3rd ed."},{"key":"2024062710453469900_CIT0013","doi-asserted-by":"crossref","first-page":"e00301","DOI":"10.1002\/prp2.301","article-title":"Metabolic effects of a mitochondrial-targeted coenzyme Q analog in high fat fed obese mice","volume":"5","author":"Fink","year":"2017","journal-title":"Pharmacol. Res. Perspect"},{"key":"2024062710453469900_CIT0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/tas\/txx003","article-title":"Diurnal heat stress reduces pig intestinal integrity and increases endotoxin translocation","volume":"2","author":"Gabler","year":"2018","journal-title":"Transl Anim Sci"},{"key":"2024062710453469900_CIT0015","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jas\/skx083","article-title":"Short-term heat stress altered metabolism and insulin signaling in skeletal muscle","volume":"96","author":"Ganesan","year":"2018","journal-title":"J. Anim. Sci"},{"key":"2024062710453469900_CIT0016","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1677\/joe.1.06262","article-title":"Gastric immunolocalization and plasma profiles of acyl-ghrelin in fasted and fasted-refed prepubertal gilts","volume":"186","author":"Govoni","year":"2005","journal-title":"J. Endocrinol"},{"key":"2024062710453469900_CIT0017","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1152\/jappl.1994.77.2.548","article-title":"Hyperthermia stimulates nitric oxide formation: electron paramagnetic resonance detection of \u2219NO-heme in blood","volume":"77","author":"Hall","year":"1994","journal-title":"J. Appl. Physiol"},{"key":"2024062710453469900_CIT0018","first-page":"G1195","article-title":"Splanchnic tissues undergo hypoxic stress during whole body hyperthermia","volume":"276","author":"Hall","year":"1999","journal-title":"Am. J. Physiol"},{"key":"2024062710453469900_CIT0019","doi-asserted-by":"crossref","first-page":"H509","DOI":"10.1152\/ajpheart.2001.280.2.H509","article-title":"Mechanism of circulatory and intestinal barrier dysfunction during whole body hyperthermia","volume":"280","author":"Hall","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol"},{"key":"2024062710453469900_CIT0020","doi-asserted-by":"crossref","first-page":"474","DOI":"10.2527\/1998.762474x","article-title":"Behavioral, endocrine, immune, and performance measures for pigs exposed to acute stress","volume":"76","author":"Hicks","year":"1998","journal-title":"J. Anim. Sci"},{"key":"2024062710453469900_CIT0021","doi-asserted-by":"crossref","first-page":"8380","DOI":"10.3168\/jds.2021-20330","article-title":"Invited review: The influence of immune activation on transition cow health and performance-A critical evaluation of traditional dogmas","volume":"104","author":"Horst","year":"2021","journal-title":"J. Dairy Sci"},{"key":"2024062710453469900_CIT0022","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41419-018-0436-x","article-title":"The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2\/ARE signaling pathway","volume":"9","author":"Hu","year":"2018","journal-title":"Cell Death Dis"},{"key":"2024062710453469900_CIT0023","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2527\/jas.2014-8354","article-title":"Effects of in utero heat stress on postnatal body composition in pigs: I. Growing phase","volume":"93","author":"Johnson","year":"2015","journal-title":"J. Anim. Sci"},{"key":"2024062710453469900_CIT0024","doi-asserted-by":"crossref","first-page":"10333","DOI":"10.1073\/pnas.1820130116","article-title":"Heat stress directly impairs gut integrity and recruits distinct immune cell populations into the bovine intestine","volume":"116","author":"Koch","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"2024062710453469900_CIT0025","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1152\/jappl.1988.64.6.2582","article-title":"Peripheral vascular responses to hyperthermia in the rat","volume":"64","author":"Kregel","year":"1988","journal-title":"J. Appl. Physiol"},{"key":"2024062710453469900_CIT0026","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.2527\/jas2017.1830","article-title":"Estimating glucose requirements of an activated immune system in growing pigs","volume":"95","author":"Kvidera","year":"2017","journal-title":"J. Anim. Sci"},{"key":"2024062710453469900_CIT0027","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.3168\/jds.2016-12001","article-title":"Glucose requirements of an activated immune system in lactating Holstein cows","volume":"100","author":"Kvidera","year":"2017","journal-title":"J. Dairy Sci"},{"key":"2024062710453469900_CIT0028","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00003677-200410000-00011","article-title":"Role of gastrointestinal permeability in exertional heatstroke","volume":"32","author":"Lambert","year":"2004","journal-title":"Exerc. Sport Sci. Rev"},{"key":"2024062710453469900_CIT0029","doi-asserted-by":"crossref","first-page":"E101","DOI":"10.2527\/jas.2008-1339","article-title":"Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects","volume":"87","author":"Lambert","year":"2009","journal-title":"J. Anim. Sci"},{"key":"2024062710453469900_CIT0030","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1152\/japplphysiol.00787.2001","article-title":"Selected contribution: hyperthermia-induced intestinal permeability and the role of oxidative and nitrosative stress","volume":"92","author":"Lambert","year":"2002","journal-title":"J. Appl. Physiol"},{"key":"2024062710453469900_CIT0031","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1113\/EP085746","article-title":"Selenium and vitamin E together improve intestinal epithelial barrier function and alleviate oxidative stress in heat-stressed pigs","volume":"101","author":"Liu","year":"2016","journal-title":"Exp. Physiol"},{"key":"2024062710453469900_CIT0032","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/jpn.12689","article-title":"Effects of a short-term supranutritional selenium supplementation on redox balance, physiology and insulin-related metabolism in heat-stressed pigs","volume":"102","author":"Liu","year":"2018","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl)"},{"key":"2024062710453469900_CIT0033","doi-asserted-by":"crossref","first-page":"263","DOI":"10.5713\/ajas.17.0256","article-title":"A short-term supranutritional vitamin E supplementation alleviated respiratory alkalosis but did not reduce oxidative stress in heat stressed pigs","volume":"31","author":"Liu","year":"2018","journal-title":"Asian-Australas. J. Anim. Sci"},{"key":"2024062710453469900_CIT0034","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.freeradbiomed.2008.09.003","article-title":"The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis","volume":"45","author":"Lowes","year":"2008","journal-title":"Free Radic. Biol. Med"},{"key":"2024062710453469900_CIT0035","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/jpn.12326","article-title":"Effects of dietary supplementation of selenium-enriched probiotics on production performance and intestinal microbiota of weanling piglets raised under high ambient temperature","volume":"99","author":"Lv","year":"2015","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl)"},{"key":"2024062710453469900_CIT0036","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.3390\/nu6062478","article-title":"Selenium-enriched Agaricus bisporus mushroom protects against increase in gut permeability ex vivo and up-regulates glutathione peroxidase 1 and 2 in hyperthermally-induced oxidative stress in rats","volume":"6","author":"Maseko","year":"2014","journal-title":"Nutrients"},{"key":"2024062710453469900_CIT0037","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.theriogenology.2020.05.023","article-title":"Biology of heat stress; the nexus between intestinal hyperpermeability and swine reproduction","volume":"154","author":"Mayorga","year":"2020","journal-title":"Theriogenology"},{"key":"2024062710453469900_CIT0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jas\/skab145","article-title":"Rapamycin administration during an acute heat stress challenge in growing pigs","volume":"99","author":"Mayorga","year":"2021","journal-title":"J. Anim. Sci"},{"key":"2024062710453469900_CIT0039","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/tas\/txab072","article-title":"Effects of dietary live yeast supplementation on growth performance and biomarkers of metabolism in heat-stressed and nutrient-restricted pigs","volume":"5","author":"Mayorga","year":"2021","journal-title":"Transl. Anim. Sci"},{"key":"2024062710453469900_CIT0040","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jtherbio.2005.07.003","article-title":"Effect of the acclimation to high environmental temperature on the activity of hepatic glycogen phosphorylase (a+b and a), liver glycogen content and blood glucose level in rats","volume":"30","author":"Mitev","year":"2005","journal-title":"J. Therm. Biol"},{"key":"2024062710453469900_CIT0041","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.pharmtox.47.120505.105110","article-title":"Targeting antioxidants to mitochondria by conjugation to lipophilic cations","volume":"47","author":"Murphy","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol"},{"key":"2024062710453469900_CIT0042","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2141\/jpsa.0190004","article-title":"Heat stress directly affects intestinal integrity in broiler chickens","volume":"57","author":"Nanto-Hara","year":"2020","journal-title":"J. Poult. Sci"},{"key":"2024062710453469900_CIT0043","volume-title":"Nutrient requirements of swine","author":"NRC","year":"2012","edition":"11th rev. ed."},{"key":"2024062710453469900_CIT0044","doi-asserted-by":"crossref","first-page":"R845","DOI":"10.1152\/ajpregu.00595.2011","article-title":"Hyperthermia induces injury to the intestinal mucosa in the mouse: evidence for an oxidative stress mechanism","volume":"302","author":"Oliver","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol"},{"key":"2024062710453469900_CIT0045","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.2527\/jas.2013-6759","article-title":"Heat stress and reduced plane of nutrition decreases intestinal integrity and function in pigs","volume":"91","author":"Pearce","year":"2013","journal-title":"J. Anim. Sci"},{"key":"2024062710453469900_CIT0046","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.2527\/jas.2014-8407","article-title":"Short term exposure to HS attenuates appetite and intestinal integrity in growing pigs","volume":"92","author":"Pearce","year":"2014","journal-title":"J. Anim. Sci"},{"key":"2024062710453469900_CIT0047","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.2527\/jas.2015-9018","article-title":"Dietary organic zinc attenuates heat stressed-induced changes in pig intestinal integrity and metabolism","volume":"93","author":"Pearce","year":"2015","journal-title":"J. Anim. Sci"},{"key":"2024062710453469900_CIT0048","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1017\/S1751731111002448","article-title":"Adaptation to hot climate and strategies to alleviate heat stress in livestock production","volume":"6","author":"Renaudeau","year":"2012","journal-title":"Animal"},{"key":"2024062710453469900_CIT0049","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0301-6226(91)90120-F","article-title":"Assessment of optimal temperature for performance and chemical body composition of growing pigs","volume":"29","author":"Rinaldo","year":"1991","journal-title":"Livest. Prod. Sci"},{"key":"2024062710453469900_CIT0050","doi-asserted-by":"crossref","first-page":"102900","DOI":"10.1016\/j.jtherbio.2021.102900","article-title":"The effect of Mitoquinol (MitoQ) on heat stressed skeletal muscle from pigs, and a potential confounding effect of biological sex","volume":"97","author":"Rudolph","year":"2021","journal-title":"J. Therm. Biol"},{"key":"2024062710453469900_CIT0051","first-page":"e12315","article-title":"Effects of heat stress on carbohydrate and lipid metabolism in growing pigs","volume":"3","author":"Sanz Fernandez","year":"2015","journal-title":"Phys. Rep"},{"key":"2024062710453469900_CIT0052","doi-asserted-by":"crossref","first-page":"e12478","DOI":"10.14814\/phy2.12478","article-title":"Heat stress increases insulin sensitivity in pigs","volume":"3","author":"Sanz Fernandez","year":"2015","journal-title":"Physiol. Rep"},{"key":"2024062710453469900_CIT0053","doi-asserted-by":"crossref","first-page":"G847","DOI":"10.1152\/ajpgi.2000.278.6.G847","article-title":"Chronic stress impairs rat growth and jejunal epithelial barrier function: role of mast cells","volume":"278","author":"Santos","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol"},{"key":"2024062710453469900_CIT0054","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3390\/antiox8090336","article-title":"Growth performance and characterization of meat quality of broiler chickens supplemented with betaine and antioxidants under cyclic heat stress","volume":"8","author":"Shakeri","year":"2019","journal-title":"Antioxidants"},{"key":"2024062710453469900_CIT0055","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/jas\/skz122.131","article-title":"Impact of heat stress and antioxidant supplements in feed or drinking water on growth, intestinal morphology, and oxidative and immune status in growing pigs","volume":"97","author":"Silva-Guillen","year":"2019","journal-title":"J. Anim. Sci"},{"key":"2024062710453469900_CIT0056","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/mds.23148","article-title":"A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson\u2019s disease","volume":"25","author":"Snow","year":"2010","journal-title":"Mov. Dis"},{"key":"2024062710453469900_CIT0057","doi-asserted-by":"crossref","first-page":"E52","DOI":"10.3168\/jds.S0022-0302(03)74040-5","article-title":"Economic losses from heat stress by US livestock industries","volume":"86","author":"St-Pierre","year":"2003","journal-title":"J. Dairy Sci"},{"key":"2024062710453469900_CIT0058","doi-asserted-by":"crossref","first-page":"R1095","DOI":"10.1152\/ajpregu.90902.2008","article-title":"MitoQ administration prevents endotoxin-induced cardiac dysfunction","volume":"297","author":"Supinski","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol"},{"key":"2024062710453469900_CIT0059","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","article-title":"Mitochondrial formation of reactive oxygen species","volume":"552","author":"Turrens","year":"2003","journal-title":"J. Physiol"},{"key":"2024062710453469900_CIT0060","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3168\/jds.S0022-0302(06)72123-3","article-title":"Acute experimental mastitis is not causal toward the development of energy-related metabolic disorders in early postpartum dairy cows","volume":"89","author":"Waldron","year":"2006","journal-title":"J. Dairy Sci"},{"key":"2024062710453469900_CIT0061","doi-asserted-by":"crossref","first-page":"e102537","DOI":"10.1371\/journal.pone.0102537","article-title":"Effects of hydration level and heat stress on thermoregulatory responses, hematological and blood rheological properties in growing pigs","volume":"9","author":"Waltz","year":"2014","journal-title":"PLoS One"},{"key":"2024062710453469900_CIT0062","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/10253890.2012.680526","article-title":"Involvement of oxidative stress and mitogen-activated protein kinase signaling pathways in heat stress-induced injury in the rat small intestine","volume":"16","author":"Yu","year":"2011","journal-title":"Stress"},{"key":"2024062710453469900_CIT0063","doi-asserted-by":"crossref","first-page":"3276148","DOI":"10.1155\/2020\/3276148","article-title":"MitoQ modulates lipopolysaccharide-induced intestinal barrier dysfunction via regulating Nrf2 signaling","volume":"2020","author":"Zhang","year":"2020","journal-title":"Mediat. Inflamm"}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jas\/advance-article-pdf\/doi\/10.1093\/jas\/skae161\/58196431\/skae161.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/doi\/10.1093\/jas\/skae161\/58345317\/skae161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/doi\/10.1093\/jas\/skae161\/58345317\/skae161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T10:49:37Z","timestamp":1719485377000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/doi\/10.1093\/jas\/skae161\/7691035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":63,"URL":"https:\/\/doi.org\/10.1093\/jas\/skae161","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"type":"print","value":"0021-8812"},{"type":"electronic","value":"1525-3163"}],"subject":[],"published-other":{"date-parts":[[2024]]},"published":{"date-parts":[[2024]]},"article-number":"skae161"}}