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Pigs were fed with basal diet (control) or basal diet supplemented with 100, 200, 400, and 800 mg\/kg CM. The trial lasted for 42 d, and pigs from the control and optimal-dose groups (based on growth performance) were picked for blood and tissue collection (n\u2005=\u20056). Results showed that CM elevated the average daily gain (ADG) and decreased the ratio of feed intake to gain (F:G) in the weaned pigs (P\u2005&amp;lt;\u20050.05). CM supplementation at 100 mg\/kg improved the digestibilities of dry matter (DM), crude protein (CP), and gross energy (GE) (P\u2005&amp;lt;\u20050.05). CM not only increased the activities of superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT) but also increased the concentration of interleukin-10 (IL-10) in serum (P\u2005&amp;lt;\u20050.05). The serum concentrations of malondialdehyde (MDA), d-lactate, and diamine oxidase (DAO) were reduced by CM (P\u2005&amp;lt;\u20050.05). Interestingly, CM elevated the villus height and the ratio of villus height to crypt depth in the duodenum and jejunum and increased the activities of duodenal sucrase and maltase (P\u2005&amp;lt;\u20050.05). Moreover, CM elevated the expression levels of tight-junction proteins ZO-1, claudin-1, and occluding, as well as critical functional genes such as the fatty acid transport protein (FATP1), cationic amino acid transporter 1 (CAT1), and NF-E2-related factor 2 (Nrf2) in the duodenum and jejunum (P\u2005&amp;lt;\u20050.05). Importantly, CM increased the concentrations of acetic acid and butyric acid, and elevated the abundances of Bacillus and Lactobacillus in the cecum and colon, respectively (P\u2005&amp;lt;\u20050.05). These results indicated potential benefits of CM in improving the growth of weaned pigs, and such effect may be tightly associated with improvement in antioxidant capacity and intestinal epithelium functions.<\/jats:p>","DOI":"10.1093\/jas\/skae194","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T04:42:33Z","timestamp":1720845753000},"source":"Crossref","is-referenced-by-count":4,"title":["Effect of cordyceps militaris on growth performance, antioxidant capacity, and intestinal epithelium functions in weaned pigs"],"prefix":"10.1093","volume":"102","author":[{"given":"YanPing","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University , Sichuan Province, Chengdu 611130 , People\u2019s Republic of China"},{"name":"Key Laboratory of Animal Disease-resistant Nutrition , Sichuan Province, Chengdu 611130 , People\u2019s Republic of 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