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Twenty-four newly weaned pigs at 6.2 kg\u2005\u00b1\u20050.4 body weight (BW) were allotted to three dietary treatments based on a randomized complete block design with sex and initial BW as blocks. Three dietary treatments are as follows: Control, typical nursery feeds including animal protein supplements and enzyme-treated soybean meal; LCF with increased amounts of soybean meal, decreased amounts of animal protein supplements, and no enzyme-treated soybean meal; LCF+, low-cost formulated feed with \u03b2-mannanase at 100 g\/t, providing 800 thermostable \u03b2-mannanase unit (TMU) per kg of feed. Pigs were fed based on a three-phase feeding program for a total of 37 d. On day 37 of feeding, all pigs were euthanized and the gastrointestinal tract was removed for sample collection to analyze intestinal health parameters, mucosa-associated microbiota, and gene expression of tight junction proteins. Pigs fed LCF increased (P\u2005&amp;lt;\u20050.05) the relative abundance of Proteobacteria and Helicobacter in the jejunal mucosa, tended to decrease (P\u2005=\u20050.097; P\u2005=\u20050.098) the concentration of malondialdehyde (MDA) and the expression of zona occluden 1 (ZO-1) gene in the jejunum, tended to decrease average daily gain (ADG; P\u2005=\u20050.084) and final BW (P\u2005=\u20050.090), and decreased (P\u2005&amp;lt;\u20050.05) average daily feed intake. Pigs fed LCF\u2005+\u2005tended to decrease (P\u2005=\u20050.088) digesta viscosity, decreased (P\u2005&amp;lt;\u20050.05) the relative abundance of Helicobacter, and increased (P\u2005&amp;lt;\u20050.05) Lactobacillus in the jejunal mucosa compared to LCF. Additionally, LCF\u2005+\u2005tended to increase final BW (P\u2005=\u20050.059) and ADG (P\u2005=\u20050.054), increased (P\u2005&amp;lt;\u20050.05) gain to feed ratio (G:F), and reduced (P\u2005&amp;lt;\u20050.05) fecal score compared to LCF. LCF with decreased amounts of animal protein supplements and increased amounts of soybean meal had negative effects on the composition of the mucosa-associated microbiota, intestinal integrity, and growth performance of nursery pigs. Beta-mannanase supplementation to LCF decreased digesta viscosity, increased the relative abundance of potentially health-benefitting microbiota such as Lactobacillus, and improved growth and fecal score, thus reflecting its efficacy in low-cost formulated feeds with increased amounts of soybean meal.<\/jats:p>","DOI":"10.1093\/jas\/skae206","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T01:09:53Z","timestamp":1721696993000},"source":"Crossref","is-referenced-by-count":13,"title":["Nutritional and functional roles of \u03b2-mannanase on intestinal health and growth of newly weaned pigs fed two different types of feeds"],"prefix":"10.1093","volume":"102","author":[{"given":"Jonathan T","family":"Baker","sequence":"first","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixiao","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adebayo","family":"Sokale","sequence":"additional","affiliation":[{"name":"BASF Corp , Florham Park, NJ 07932 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Frederick","sequence":"additional","affiliation":[{"name":"Cargill Animal Nutrition NA , Minneapolis, MN 55450 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-1943","authenticated-orcid":false,"given":"Sung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"2024080807164368100_CIT0001","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.3390\/ijms20071630","article-title":"Characterization of microbiota associated with digesta and mucosa in different regions of gastrointestinal tract of nursery pigs","volume":"20","author":"Adhikari","year":"2019","journal-title":"Int. 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Braz","volume":"15","author":"Montanhini Neto","year":"2013","journal-title":"J. Poult. Sci"},{"key":"2024080807164368100_CIT0058","volume-title":"Nutrient requirements of swine","author":"NRC","year":"2012","edition":"11th rev. ed"},{"key":"2024080807164368100_CIT0059","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.aninu.2015.02.006","article-title":"Effect of dietary supplementation of xylanase on apparent ileal digestibility of nutrients, viscosity of digesta, and intestinal morphology of growing pigs fed corn and soybean meal based diet","volume":"1","author":"Passos","year":"2015","journal-title":"Anim. Nutr"},{"key":"2024080807164368100_CIT0060","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40104-015-0031-2","article-title":"A review of feed efficiency in swine: biology and application","volume":"6","author":"Patience","year":"2015","journal-title":"J. Anim. Sci. 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