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Sixteen weaned gilts either received a basal diet or a basal diet supplemented with 3.0\u00a0mg\/kg ZEN in a 32-d experiment. The results showed that ZEN at the concentration of 3.0\u00a0mg\/kg diet activated the inflammatory response and caused oxidative stress of gilts (P\u2005&amp;lt;\u20050.05). ZEN exposure resulted in the upregulation (P\u2005&amp;lt;\u20050.05) of the Exchange protein directly activated by the cAMP 1\/Ras-related protein1\/c-Jun N-terminal kinase (Epac1\/Rap1\/JNK) signaling pathway in the jejunum of gilts in vivo and in the intestinal porcine epithelial cells in vitro. The cell viability, EdU-positive cells, and the mRNA expression of B-cell lymphoma-2 (Bcl-2) were decreased, whereas the reactive oxygen species production and the mRNA expressions of Bcl-2-associated X (Bax) and Cysteine-aspartic acid protease 3 (Caspase3) were increased (P\u2005&amp;lt;\u20050.05) by ZEN. However, ZEN increased the mRNA expression of Bcl-2 and decreased the mRNA expressions of Bax and caspase3 (P\u2005&amp;lt;\u20050.05) after the Epac1 was blocked. These results collectively indicated that a 3.0\u00a0mg ZEN \/kg diet induced jejunal damage via the Epac1\/Rap1\/JNK signaling pathway.<\/jats:p>","DOI":"10.1093\/jas\/skae208","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T12:26:16Z","timestamp":1721910376000},"source":"Crossref","is-referenced-by-count":5,"title":["Effect of zearalenone on the jejunum of weaned gilts through the Epac1\/Rap1\/JNK pathway"],"prefix":"10.1093","volume":"102","author":[{"given":"Heng","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018 , China"},{"name":"Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Animal Nutrition Institute , Chengdu , China"},{"name":"Key Laboratory of Animal Disease-Resistant Nutrition of Sichuan Province, Sichuan Agricultural University , Chengdu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Fu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Shandong Agricultural University , Tai\u2019an 271018 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Wang","sequence":"additional","affiliation":[{"name":"Agriculture and Agri-Food Canada, Lethbridge Research and Development Centre , Lethbridge, AB , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiren","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"2024090211412720300_CIT0001","doi-asserted-by":"crossref","first-page":"168648","DOI":"10.1016\/j.scitotenv.2023.168648","article-title":"Toxicity, biodegradation, and nutritional intervention mechanism of zearalenone","volume":"911","author":"Cai","year":"2023","journal-title":"Sci. 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