{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T11:08:45Z","timestamp":1788001725963,"version":"build-2784847793"},"reference-count":43,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The beneficial effects of xylo-oligosaccharides (XOS) on the intestine have been widely reported, including anti-inflammation, antioxidant, maintenance of intestinal epithelial barrier, and treatment of intestinal injury. However, the specific mechanism of XOS in mitigating intestinal injury in weaned piglets remains unclear. Therefore, this study aimed to explore the specific mechanism of XOS in mitigating intestinal injury. The study is a complete randomized design with 24 weaned piglets in a 2\u2005\u00d7\u20052 factorial arrangement that includes diet treatments (basal diet vs. 0.02% XOS) and immunological challenge [saline vs. lipopolysaccharide (LPS)]. All piglets were fed a basal diet or a XOS diet for 21 d. On day 22, all piglets received an injection of LPS or saline. In this study, dietary XOS increased jejunal villus height, reduced crypt depth and oxidative stress, and enhanced the gene and protein expression of Claudin-1, Occludin, and zonula occludens 1 (P\u2005&amp;lt;\u20050.05). The piglets fed the XOS diet had lower serum Diamine oxidase activity and d-lactic acid content (P\u2005&amp;lt;\u20050.05). In addition, dietary XOS regulates endoplasmic reticulum (ER)\u2013mitochondria system function and the expression of key molecules, including mitochondrial dynamics dysfunction [mitofusin (Mfn)-1, optic atrophy 1, fission 1, and dynamin-related protein 1], ER stress [activating transcription factor 4 (ATF4), ATF6, C\/EBP-homologous protein, eukaryotic initiation factor 2\u03b1, glucose-regulated protein (GRP) 78, GRP94, and protein kinase R-like ER kinase] and the mitochondria-associated ER membranes (MAM) disorders (Mfn2, GRP75, and voltage-dependent anion channel 1) (P\u2005&amp;lt;\u20050.05). Therefore, the findings to indicate that dietary XOS is effective against LPS-induced jejunal injury may be attributed to its ability to alleviate mitochondrial dynamics dysfunction, ER stress, and MAM disorders.<\/jats:p>","DOI":"10.1093\/jas\/skae238","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T23:06:29Z","timestamp":1723763189000},"source":"Crossref","is-referenced-by-count":6,"title":["Dietary xylo-oligosaccharides alleviates LPS-induced intestinal injury via endoplasmic reticulum-mitochondrial system pathway in piglets"],"prefix":"10.1093","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-7528","authenticated-orcid":false,"given":"Guangmang","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University , Chengdu, Sichuan, China"},{"name":"Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education , Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University , Chengdu, Sichuan, China"},{"name":"Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education , Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruinan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University , Chengdu, Sichuan, China"},{"name":"Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education , Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Environmental Sciences, Sichuan Agricultural University , Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Jia","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University , Chengdu, Sichuan, China"},{"name":"Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education , Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University , Chengdu, Sichuan, China"},{"name":"Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education , Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University , Chengdu, Sichuan, China"},{"name":"Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education , Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Maize Research Institute, Sichuan Agricultural University , Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"2024092302415366100_CIT0001","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.freeradbiomed.2018.11.005","article-title":"Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid","volume":"130","author":"Aparicio-Trejo","year":"2019","journal-title":"Free Radic. 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