{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:43:41Z","timestamp":1790045021483,"version":"4.0.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32130099"],"award-info":[{"award-number":["32130099"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Innovation Program of Hunan Province","award":["2022RC3060"],"award-info":[{"award-number":["2022RC3060"]}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ6310"],"award-info":[{"award-number":["2024JJ6310"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Postdoctoral Fellowship Program of CPSF","award":["GZC20230779"],"award-info":[{"award-number":["GZC20230779"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study aimed to investigate the effect of feed intake levels on the development of intestinal morphology and epithelial cell differentiation in piglets. Sixty-four 35-d-old healthy weaned piglets ([Large White\u2005\u00d7\u2005Landrace]\u2005\u00d7\u2005Duroc) with an initial weight (6.93\u2005\u00b1\u20050.12\u00a0kg) were randomly divided into 4 groups (100%, 80%, 40%, and 20% feed intake) with 8 replicates of 2 pigs each. Samples were collected on days 3 and 7. The results revealed that with an increase in feed restriction degree and time, the body weight and organ index of piglets significantly decreased, and the villus height (VH) and crypt depth of the duodenum, jejunum, and ileum also decreased linearly (P\u2005&amp;lt;\u20050.05). After 3\u00a0d of feed restriction, jejunal ki67, endocrine cells, goblet cells, and villus endocrine\/VH all decreased linearly, but the villus cup\/VH ratio increased linearly, and the 40% and 20% were significantly higher than those of the 100% and 80% (P\u2005&amp;lt;\u20050.05). There was also a linear decrease in jejunal ki67, endocrine cells, goblet cells, and villous endocrine\/VH in piglets fed 7\u00a0d of food restriction; however, the villus goblet cells\/VH ratio in the 20% was significantly higher than that in the 40% group and was not different from that in the 80% (P\u2005&amp;lt;\u20050.05). During 3\u00a0d of feed restriction, the expression of jejunal differentiation marker genes showed a linear decreasing trend (P\u2005&amp;lt;\u20050.05) but increased linearly after 7\u00a0d of feed restriction. The expression levels of interleukin17 (IL-17) and IL-22 also increased linearly (P\u2005&amp;lt;\u20050.05). Kyoto Encyclopedia of Genes and Genomes and gene set enrichment analysis analyses indicated that the PPAR signaling pathway, ECM\u2013receptor interaction, and Th1, Th2, and Th17 cell differentiation were significantly enriched in these processes. real-time quantitative polymerase chain reaction demonstrated that both PPAR and ECM\u2013receptor interactions were significantly activated during 7\u00a0d of feeding restriction (P\u2005&amp;lt;\u20050.05). The results showed that with an increase in feed restriction intensity and time, the intestinal morphology and epithelial cell proliferation and differentiation were significantly reduced, except for the goblet cells. This phenomenon is related to the regulation of intestinal differentiation by IL-17 and IL-22 secreted by the Th cells.<\/jats:p>","DOI":"10.1093\/jas\/skae262","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T05:04:47Z","timestamp":1725599087000},"source":"Crossref","is-referenced-by-count":11,"title":["Impact of different feed intake levels on intestinal morphology and epithelial cell differentiation in piglets"],"prefix":"10.1093","volume":"103","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University , Changsha, Hunan 410081 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,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4024-2341","authenticated-orcid":false,"given":"Qiye","family":"Wang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University , Changsha, Hunan 410081 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1164-5771","authenticated-orcid":false,"given":"Huansheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal 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