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Therefore, blood analysis can be a convenient method for evaluating reproductive traits in sheep by detecting genetic and metabolic changes in the ovary. By combining 167 RNA sequencing data and 60 untargeted metabolomics data, this study analyzed the relationship between genes and metabolites in the ovary and blood. The conjoint KEGG enrichment analysis enriched glutathione (GSH) metabolic pathways both in the ovary and blood. This finding provides an explanation for possible GSH metabolic processes in the ovary with metabolite exchange in the blood. The metabolite\u2013gene\u2013disease interaction network revealed a correlation between the expression of certain Bardet\u2013Biedl syndrome (BBS) family genes in the ovary and blood. This indicates that BBS family genes, such as BBS10 in sheep blood, could be a potential biomarker for BBS. We investigated the relationship between BBS10 gene expression in the ovary and lambing numbers using whole-genome sequencing data from 450 ewes. Our findings suggest that g.112314188C&amp;gt;G may lead to decreased litter size in ewes carrying the FecB gene. These single nucleotide polymorphisms could be potential molecular markers for breeding sheep.<\/jats:p>","DOI":"10.1093\/jas\/skae273","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T12:45:05Z","timestamp":1727181905000},"source":"Crossref","is-referenced-by-count":0,"title":["Integration of multi-omics reveals the important role of the <i>BBS10<\/i> gene in reproduction"],"prefix":"10.1093","volume":"102","author":[{"given":"Guoqing","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS) , Beijing 100193 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxing","family":"Chu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS) , Beijing 100193 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoufeng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, University of Jinan , Jinan 250022 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingjie","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS) , Beijing 100193 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS) , Beijing 100193 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS) , Beijing 100193 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyue","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS) , Beijing 100193 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangyuan","family":"Pan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS) , Beijing 100193 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"2024102215254122300_CIT0001","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.gene.2013.03.133","article-title":"Association of BMPR-1B and GDF9 genes polymorphisms and secondary protein structure changes with reproduction traits in Mehraban ewes","volume":"524","author":"Abdoli","year":"2013","journal-title":"Gene"},{"key":"2024102215254122300_CIT0002","doi-asserted-by":"crossref","first-page":"9530","DOI":"10.1016\/S0021-9258(18)43421-7","article-title":"Dynamic state of glutathione in blood plasma","volume":"255","author":"Anderson","year":"1980","journal-title":"J. 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