{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:59:27Z","timestamp":1770742767963,"version":"3.49.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":261,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study examined the action of a blend of botanicals (BOT) against lipopolysaccharide (LPS)-induced inflammation on cultured hepatocytes and weaning piglets. In vitro studies examined HepG2 cells treated with BOT and challenged with Escherichiacoli LPS for 8 d. BOT treatment reduced IL-6 concentration in cell culture media across time (P\u2005&amp;lt;\u20050.05) and decreased pro-inflammatory cytokine expression on days 1 and 8 of experiment (TNF\u03b1, IL-1\u03b2; P\u2005&amp;lt;\u20050.05). BOT also increased the expression of antioxidant enzymes (GPX-2, SOD, CAT) on day 8 (P\u2005&amp;lt;\u20050.05), which was supported by lowered reactive oxygen species concentration after LPS challenge (P\u2005&amp;lt;\u20050.1). The in vivo study was conducted with 72 weaning pigs, allotted into 24 pens and divided into 3 groups: a negative control (CTR\u2212, basal diet), a challenged control (CTR+) that received an intraperitoneal injection of E. coli O55:B5 LPS on days 14 and 16, and a challenged treated group which received a diet containing 1.5\u00a0g\/kg of microencapsulated BOT (BOT+) for the whole duration of the study. Growth performance was determined weekly and, on days 21 (1 animal per pen) and 28 (remaining animals), pigs were sacrificed to collect liver and jejunal tissues. After the challenge, BOT+ pigs had increased BW on days 21 (P\u2005&amp;lt;\u20050.05) and 28 (P\u2005&amp;lt;\u20050.1) compared to CTR+. Similar improvements in average daily gain and FCR on days 14 to 21 (P\u2005&amp;lt;\u20050.05) and 21 to 28 (P\u2005&amp;lt;\u20050.1) were also seen in BOT+ group. In the liver, compared to CTR+ pigs, BOT+ pigs had\u00a0downregulated expression of TLR-4, IL-6, IFN-\u03b3 on day 21 (P\u2005&amp;lt;\u20050.05), and TLR-4, TNF-\u03b1, IL-8 on day 28 (P\u2005&amp;lt;\u20050.05). BOT+ also increased GPX-2 expression on days 21 and 28 (P\u2005&amp;lt;\u20050.05), while also upregulating SOD-1 and SOD-2 on day 21 (P\u2005&amp;lt;\u20050.05) and CAT on day 28 (P\u2005&amp;lt;\u20050.05) compared to CTR+. In the jejunum, BOT+ reduced inflammation by affecting cytokine expression (P\u2005&amp;lt;\u20050.05) and increasing the expression of tight-junction proteins, ZO-1 on day 21 and CLD-1 on day 28 (P\u2005&amp;lt;\u20050.05). Furthermore, BOT+ pigs had lower crypt depth on days 21 (P\u2005&amp;lt;\u20050.1) and 28 (P\u2005&amp;lt;\u20050.05), and increased villi-to-crypt ratio on days 21 and 28 (P\u2005&amp;lt;\u20050.05). By day 28, BOT+ intestinal measurements were restored to values similar to the CTR\u2212. Finally, BOT+ also reduced mast cell activation on day 21 (P\u2005&amp;lt;\u20050.05) compared to CTR+. Considering all the findings, BOT controlled inflammatory activation and oxidative stress in liver cells, enhanced intestinal integrity, and as a result improved the growth performance of weaning piglets challenged with LPS.<\/jats:p>","DOI":"10.1093\/jas\/skae277","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T06:26:56Z","timestamp":1726640816000},"source":"Crossref","is-referenced-by-count":3,"title":["A microencapsulated blend of botanicals supports weaning piglets during a lipopolysaccharide challenge by modulating liver inflammation and intestinal integrity"],"prefix":"10.1093","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5597-748X","authenticated-orcid":false,"given":"Andrea","family":"Bonetti","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Mediche Veterinarie (DIMEVET), Universit\u00e0 di Bologna , Bologna ,","place":["Italy"]},{"name":"Vetagro S.p.A. , Reggio Emilia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetta","family":"Tugnoli","sequence":"additional","affiliation":[{"name":"Vetagro S.p.A. , Reggio Emilia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0414-7777","authenticated-orcid":false,"given":"Federico","family":"Ghiselli","sequence":"additional","affiliation":[{"name":"Vetagro S.p.A. , Reggio Emilia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Markley","sequence":"additional","affiliation":[{"name":"Department of Animal and Avian Sciences, University of Maryland , College Park 20742, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Animal and Avian Sciences, University of Maryland , College Park 20742, MD ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1631-3311","authenticated-orcid":false,"given":"Andrea","family":"Piva","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche Veterinarie (DIMEVET), Universit\u00e0 di Bologna , Bologna ,","place":["Italy"]},{"name":"Vetagro S.p.A. , Reggio Emilia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad H","family":"Stahl","sequence":"additional","affiliation":[{"name":"Department of Animal and Avian Sciences, University of Maryland , College Park 20742, MD ,","place":["USA"]},{"name":"Vetagro Inc. , Chicago 60603, IL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8351-9542","authenticated-orcid":false,"given":"Ester","family":"Grilli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche Veterinarie (DIMEVET), Universit\u00e0 di Bologna , Bologna ,","place":["Italy"]},{"name":"Vetagro Inc. , Chicago 60603, IL ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"2024101012314980900_CIT0001","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.3390\/ani11123471","article-title":"Phytogenic feed additives in poultry: achievements, prospective and challenges","volume":"11","author":"Abdelli","year":"2021","journal-title":"Animals"},{"key":"2024101012314980900_CIT0002","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41522-022-00352-6","article-title":"Host-microbiome interactions: gut-liver axis and its connection with other organs","volume":"8","author":"Anand","year":"2022","journal-title":"NPJ Biofilms Microbiomes"},{"key":"2024101012314980900_CIT0003","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3390\/ani11030642","article-title":"Towards zero zinc oxide: feeding strategies to manage post-weaning diarrhea in piglets","volume":"11","author":"Bonetti","year":"2021","journal-title":"Animals"},{"key":"2024101012314980900_CIT0004","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3389\/fvets.2023.1141561","article-title":"Botanicals as a zinc oxide alternative to protect intestinal cells from an Escherichia coli F4 infection in vitro by modulation of enterocyte inflammatory response and bacterial virulence","volume":"10","author":"Bonetti","year":"2023","journal-title":"Front. 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