{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:12:47Z","timestamp":1789647167958,"version":"4.0.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study was conducted to investigate the effects of Romboutsia ilealis on the immune function of broilers and the underlying mechanisms. A total of 48 one-day-old Arbor Acres broilers were allocated to 4 groups as follows: broilers treated daily with 1\u00a0mL live R. ilealis in general anaerobic medium broth media (0, 1\u2005\u00d7\u2005104, 1\u2005\u00d7\u2005106, and 1\u2005\u00d7\u2005108 CFU\/mL) from days 1 to 7. Samples were collected on days 8 and 14. The results showed that R. ilealis had no negative effect on the body weight of broilers (P\u2005&amp;gt;\u20050.05). R. ilealis significantly increased the levels of lysozyme, IFN-\u03b3, IFN-\u03b3\/IL-4, and IgG in the serum (P\u2005&amp;lt;\u20050.05). R. ilealis significantly increased the levels of IL-4, IFN-\u03b3, sIgA, lysozyme, and iNOS in the ileal mucosa (P\u2005&amp;lt;\u20050.05). R. ilealis significantly increased the mRNA levels of TLR2, TLR4, NF-\u03baB, IL-1\u03b2, TNF-\u03b1, IFN-\u03b3, IgA, pIgR, iNOS, and MHC-II in the ileum (P\u2005&amp;lt;\u20050.05). R. ilealis significantly increased the relative abundance of Enterococcus and Paracoccus in the jejunum and ileum, ileal Candidatus Arthromitus, and cecal Romboutsia and Intestinimonas (P\u2005&amp;lt;\u20050.05). Correlation analysis showed that Enterococcus, Paracoccus, Romboutsia, and Intestinimonas were significantly positively correlated with humoral immune function (P\u2005&amp;lt;\u20050.05). In conclusion, R. ilealis boosted the immune system, activated the intestinal TLR2\/NF-\u03baB signaling pathway, and improved the gut microbiota in broilers.<\/jats:p>","DOI":"10.1093\/jas\/skae286","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T12:10:50Z","timestamp":1726920650000},"source":"Crossref","is-referenced-by-count":32,"title":["The improvement of immunity and activation of TLR2\/NF-\u03baB signaling pathway by <i>Romboutsia ilealis<\/i> in broilers"],"prefix":"10.1093","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2421-8288","authenticated-orcid":false,"given":"Bochen","family":"Song","sequence":"first","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-grain Feed Resources, College of Animal Science and Technology, Shandong Agricultural University , Taian, Shandong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4622-0263","authenticated-orcid":false,"given":"Peng","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-grain Feed Resources, College of Animal Science and Technology, Shandong Agricultural University , Taian, Shandong ,","place":["China"]},{"name":"Precision Livestock and Nutrition Unit, Gembloux Agro-Bio Tech, University of Li\u00e8ge , Gembloux ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7424-0582","authenticated-orcid":false,"given":"Linglian","family":"Kong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-grain Feed Resources, College of Animal Science and Technology, Shandong Agricultural University , Taian, Shandong ,","place":["China"]},{"name":"Department of Biological and Chemical Engineering, Jining Polytechnic , Jining, Shandong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5416-097X","authenticated-orcid":false,"given":"Chuanpi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-grain Feed Resources, College of Animal Science and Technology, Shandong Agricultural University , Taian, Shandong ,","place":["China"]},{"name":"Precision Livestock and Nutrition Unit, Gembloux Agro-Bio Tech, University of Li\u00e8ge , Gembloux ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5790-1115","authenticated-orcid":false,"given":"Xue","family":"Pan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-grain Feed Resources, College of Animal Science and Technology, Shandong Agricultural University , Taian, Shandong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1525-5797","authenticated-orcid":false,"given":"Zhigang","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-grain Feed Resources, College of Animal Science and Technology, Shandong Agricultural University , Taian, Shandong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,21]]},"reference":[{"key":"2024110813162215000_CIT0001","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1111\/jpn.13454","article-title":"Probiotics in poultry feed: a comprehensive review","volume":"104","author":"Abd El-Hack","year":"2020","journal-title":"J. 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