{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:34:17Z","timestamp":1782484457044,"version":"3.54.5"},"reference-count":53,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In this study, we investigated the effects of transplanting Ningxiang pig fecal bacteria on the ileum microflora and intestinal barrier of Duroc\u2005\u00d7\u2005Landrace\u2005\u00d7\u2005Large White (DLY) pigs. Thirty-two DLY pigs at 90-d-old were equally assigned to either control groups (fed the basal diet) or test groups (fed the basal diet\u2005+\u200510\u00a0mL fecal microbiota suspension from Ningxiang pig). Results showed that fecal microbiota transplantation (FMT) did not influence the growth performance, but increased the number of ileum goblet cells and the expression level of mucin-2. Additionally, the mucosal levels of anti-in\ufb02ammatory cytokines interlukin-4 and interlukin-10 were upregulated, but the level of pro-in\ufb02ammatory cytokine interferon-\u03b3 was downregulated by FMT. Moreover, FMT increased the expression level of porcine \u03b2 defensin-114 in ileum mucus. 16S rRNA gene sequencing of ileal digesta showed that FMT modulated the diversity and composition of ileal microbiota of DLY pigs by increasing the relative abundances of bene\ufb01cial bacteria, while decreasing the abundance of the pathogenic bacterium Streptococcus. Taken together, the study showed that FMT of Ningxiang pigs could improve the intestinal barrier condition of DLY pigs by improving intestinal microflora and promoting intestinal health.<\/jats:p>","DOI":"10.1093\/jas\/skae314","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T03:23:00Z","timestamp":1728616980000},"source":"Crossref","is-referenced-by-count":5,"title":["Transplantation of fecal microbiota from different breeds improved intestinal barrier condition and modulated ileal microflora of recipient pigs"],"prefix":"10.1093","volume":"102","author":[{"given":"Tong","family":"Yang","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University , Furong 410125 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6579-3633","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition, Hunan Institute of Animal Husbandry and Veterinary Medicine , Furong 410131 ,","place":["China"]},{"name":"Hunan Provincial Key Laboratory of the Traditional Chinese Medicine Agricultural Biogenomics, Changsha Medical University , Wangcheng 410219 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University , Furong 410125 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Yv","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University , Furong 410125 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University , Furong 410125 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University , Furong 410125 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University , Furong 410125 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Han","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University , Furong 410125 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingguo","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hunan Agricultural University , Furong 410125 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"2024121311210004100_CIT0001","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1080\/21505594.2020.1764173","article-title":"Identification of conditionally essential genes for Streptococcus suis infection in pigs","volume":"11","author":"Arenas","year":"2020","journal-title":"Virulence"},{"key":"2024121311210004100_CIT0002","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/s41396-018-0301-z","article-title":"Effect of fecal microbiota transplantation route of administration on gut colonization and host response in preterm pigs","volume":"13","author":"Brunse","year":"2019","journal-title":"ISME J"},{"key":"2024121311210004100_CIT0003","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/nri3535","article-title":"Microbiota-mediated colonization resistance against intestinal pathogens","volume":"13","author":"Buffie","year":"2013","journal-title":"Nat. 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