{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T14:22:42Z","timestamp":1782224562923,"version":"3.54.5"},"reference-count":39,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Growth hormone (GH) is an essential factor in enhancing the productivity of animals. In ruminants, L-aspartate (L-Asp) stimulates the secretion of GH; however, the effect of D-Asp on GH remains unknown. Here, we examined the effect of D-Asp on GH secretion in wethers. Blood GH, insulin, adrenaline, noradrenaline, non-esterified fatty acid (NEFA), and glucose concentrations were evaluated in response to the intravenous infusion of a high-dose (0.1 mmol\/kg\/min) of D-Asp for 20\u00a0min. Further, concentrations of these biomolecules were evaluated when a low-dose (0.05 mmol\/kg\/min) of D-Asp was continuously infused intravenously for 20\u00a0min. Finally, the direct effect of D-Asp on GH secretion was determined using cultured sections of the anterior pituitary tissue from wethers. Infusion of the high-dose of D-Asp markedly increased blood GH concentrations (P\u2005&amp;lt;\u20050.05), resulting in an increase in the area under the curve (AUC). Plasma GH concentrations and AUC also increased in response to infusion of a low D-Asp dose. Infusion of a high and low D-Asp dose caused a prolonged reduction in plasma insulin concentrations, and the AUC was lower (P\u2005&amp;lt;\u20050.05). Plasma NEFA concentrations gradually increased after the end of D-Asp infusion, with a low D-Asp dose infusion resulting in significantly higher concentrations at 90\u00a0min (P\u2005&amp;lt;\u20050.05). Plasma adrenaline, noradrenaline, and glucose concentrations did not show significant changes despite differences in the dose of D-Asp. Although D-Asp treatments stimulated GH secretion in the cultured sections of pituitary tissues, the effect was not significant. These results suggest that D-Asp stimulates the secretion of GH in wethers through not only a direct action on the pituitary gland but also through another pathway of GH stimulation.<\/jats:p>","DOI":"10.1093\/jas\/skae318","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T17:19:26Z","timestamp":1729531166000},"source":"Crossref","is-referenced-by-count":3,"title":["D-aspartate stimulates growth hormone secretion in wethers"],"prefix":"10.1093","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1542-125X","authenticated-orcid":false,"given":"Tatsuyuki","family":"Takahashi","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University Department of Animal Science, ,\u00a0 Aomori ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyosuke","family":"Kidachi","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University Department of Animal Science, ,\u00a0 Aomori ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiko","family":"Yukawa","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University Department of Animal Science, ,\u00a0 Aomori ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Hachinohe","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University Department of Animal Science, ,\u00a0 Aomori ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuina","family":"Takashima","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University Department of Animal Science, ,\u00a0 Aomori ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Fujimura","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University Department of Animal Science, ,\u00a0 Aomori ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Saito","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University Department of Animal Science, ,\u00a0 Aomori ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daichi","family":"Soga","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University Department of Animal Science, ,\u00a0 Aomori ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Ota","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University Department of Animal Science, ,\u00a0 Aomori ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Niizuma","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University Department of Animal Science, ,\u00a0 Aomori ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Sato","sequence":"additional","affiliation":[{"name":"Faculty of Bioresource Sciences, Akita Prefectural University , Akita ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Field Science Center, School of Veterinary Medicine, Kitasato University , Hokkaido ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Kurose","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University Department of Animal Science, ,\u00a0 Aomori ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"2024121022182729500_CIT0001","volume-title":"Japanese Standard for Sheep (1996)","author":"Agriculture, Forestry and Fisheries Research Council Secretariat","year":"1996"},{"key":"2024121022182729500_CIT0002","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1038\/ijo.2017.164","article-title":"l-phenylalanine modulates gut hormone release and glucose tolerance, and suppresses food intake through the calcium-sensing receptor in rodents","volume":"41","author":"Alamshah","year":"2017","journal-title":"Int. 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