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Horses were stratified by body weight (BW), age, and body condition score (BCS) to one of two treatments: concentrate formulated with 2\u00a0g starch \u00b7 kg BW\u22121 \u00b7 meal\u22121 (control (CON); n\u2005=\u200515) or the same concentrate top-dressed with 25\u00a0g\/d S. cerevisiae CNCM I-1077 (treatment (SC); n\u2005=\u200515; 8\u2005\u00d7\u2005108CFU). Horses were fed individually in stalls every 12\u00a0h. Between meals, horses were housed in dry lots with ad libitum access to water and Coastal bermudagrass hay. On days 0 and 32, BW and BCS were recorded, and blood was collected before feeding and 2, 8, 16, and 24\u00a0h postmeal on day 32 to analyze serum D-lactate. Fecal samples were collected on days 0, 16, and 32 at 8, 16, and 24\u00a0h postmeal for fecal pH and starch content. Intake and fecal production were recorded over 4 d to measure digestibility on days 28\u201331. Whole blood total bacterial counts and 16S fecal microbiota rRNA sequencing were performed at days 0, 16, and 32. Results revealed an increased\u2005\u2206BW in SC horses compared with CON horses (P\u2005=\u20050.03), with no change in BCS (P\u2005=\u20050.97). D-lactate tended to be greater in SC horses on day 32 at 16 and 24\u00a0h postmeal compared with CON horses (P\u2005=\u20050.10). Concentrations of TNF\u03b1 and LogCCL2 decreased from day 0 to day 32 regardless of dietary supplementation (P\u2005\u2264\u20050.02). Fold change of percent reads from day 0 in whole blood bacterial 16S rRNA did not differ between groups. Fecal starch was undetectable, and there were no differences in intake or apparent digestibility. Fecal pH tended (P\u2005=\u20050.07) to be lower in CON at 0\u00a0h on day 32 (6.03\u2005\u00b1\u20050.06) than on day 16 (6.14\u2005\u00b1\u20050.06). Additionally, pH tended (P\u2005=\u20050.09) to be lower in CON (6.03\u2005\u00b1\u20050.06) than in SC (6.16\u2005\u00b1\u20050.06) at 0\u00a0h on day 32. Supplementation of S. cerevisiae CNCM I-1077 maintained Bacteroidales and reduced acidosis-like bacteria like Streptococcus and potential pathogens like Enterobacteriaceae, Stenotrophomonas, and Rhodococcus at day 16 (P\u2005&amp;lt;\u20050.05). Furthermore, supplementation increased fibrolytic bacteria at day 32, such as Ruminococcus, Fibrobacter, and Succinivibrio (P\u2005&amp;lt;\u20050.05). These results indicate S. cerevisiae CNCM I-1077 increases BW and promotes a more diverse microbiome when horses are fed ad libitum hay and a high-starch concentrate.<\/jats:p>","DOI":"10.1093\/jas\/skaf005","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T12:15:04Z","timestamp":1736770504000},"source":"Crossref","is-referenced-by-count":6,"title":["Influence of <i>Saccharomyces cerevisiae<\/i> CNCM I-1077 on the fecal pH, markers of gut permeability, fecal microbiota, and markers of systemic inflammation in sedentary horses fed a high-starch diet"],"prefix":"10.1093","volume":"103","author":[{"given":"Margaret M","family":"Carter","sequence":"first","affiliation":[{"name":"Department of Animal Science, Texas A&M University and Texas A&M AgriLife Research , College Station, TX 77843 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L","family":"Leatherwood","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Tarleton State University , Stephenville, TX 76402 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2265-3857","authenticated-orcid":false,"given":"Brittany L","family":"Paris","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University and Texas A&M AgriLife Research , College Station, TX 77843 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace E","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University and Texas A&M AgriLife Research , College Station, TX 77843 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M","family":"George","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Tarleton State University , Stephenville, TX 76402 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael E","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Tarleton State University , Stephenville, TX 76402 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kip","family":"Karges","sequence":"additional","affiliation":[{"name":"Lallemand Specialties Inc. , Milwaukee, WI 53218 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi R","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University and Texas A&M AgriLife Research , College Station, TX 77843 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn E","family":"Arnold","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Texas Tech University , Amarillo, TX 79106 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kati G","family":"Glass","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences, Texas A&M University School of Veterinary Medicine , College Station, TX 77843 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda N","family":"Bradbery","sequence":"additional","affiliation":[{"name":"Department of Animal and Range Sciences, Montana State University , Bozeman, MT 59717 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Rodiles","sequence":"additional","affiliation":[{"name":"Lallemand Specialties Inc. , Milwaukee, WI 53218 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8038-4152","authenticated-orcid":false,"given":"Tryon A","family":"Wickersham","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University and Texas A&M AgriLife Research , College Station, TX 77843 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"2025042109364996500_CIT0002","doi-asserted-by":"publisher","first-page":"352","DOI":"10.3168\/jds.2019-16398","article-title":"Diet starch concentration and starch fermentability affect markers of inflammatory response and oxidant status in dairy cows during the early postpartum period","volume":"103","author":"Albornoz","year":"2020","journal-title":"J. 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