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This study aimed to evaluate the nutritional and functional values of granulated Threonine (Thr) and Valine (Val) with CGCM in diets for growth performance, jejunal mucosa-associated microbiota, nutrient digestibility, and health of nursery pigs. Seventy-two newly weaned pigs (28 d-of-age; initial body weight (BW) of 8.2\u2005\u00b1\u20050.4\u00a0kg) were allotted to 9 treatments (n\u2005=\u20058) based on a randomized complete block design with sex and initial BW as blocks. Treatments consisted of a basal diet with different levels of standardized ileal digestible (SID) Thr and Val: NC (SID Thr and SID Val at 70% of NRC requirement), CT (95% SID Thr using crystalline Thr); CV (95% SID Val using crystalline Val); PT (95% SID Thr using ThrPro); PV (95% SID Val using ValPro); HCT (5\u2005\u00d7\u2005crystalline Thr used in CT); HCV (5\u2005\u00d7\u2005crystalline Val used in CV); HPT (5\u2005\u00d7\u2005ThrPro used in PT); HPV (5\u2005\u00d7\u2005ValPro used in PV). Diets were fed to nursery pigs for 25 d in 2 phases (10 and 15 d, respectively). Feed intake and BW were recorded at the end of each phase. Blood samples were collected to measure serum proteins, metabolites, and electrolytes on day 21. Pigs were euthanized at day 25 to collect liver and jejunal tissues for morphological evaluation and jejunal mucosa to measure intestinal health biomarkers. Data were analyzed by SAS using MIXED procedure. Pigs with 95% SID Thr or 95% SID Val tended to have greater average daily gain (P\u2005=\u20050.078) and gross energy digestibility (P\u2005=\u20050.058), had greater (P\u2005&amp;lt;\u20050.05) jejunal villus height, and had lower (P\u2005&amp;lt;\u20050.05) plasma urea nitrogen and liver fibrosis than pigs with 70% SID Thr or 70% SID Val, respectively. Pigs fed a diet with HAAPro had increased (P\u2005&amp;lt;\u20050.05) alpha diversity of jejunal mucosa-associated microbiota than pigs fed a diet with AAPro. Pigs fed a diet with HAAPro had increased (P\u2005&amp;lt;\u20050.05) relative abundance of Bifidobacterium and decreased (P\u2005&amp;lt;\u20050.05) relative abundance of Comamonas than pigs fed a diet with AAPro. In conclusion, increasing the supplementation of AAPro by 5-folds than typical level did not negatively affect growth performance whereas beneficially modulated the jejunal mucosa-associated microbiota. Results suggest that AAPro can effectively replace the use of crystalline amino acids in pig diets while potentially reducing feed costs due to the reduced cost of producing such amino acids.<\/jats:p>","DOI":"10.1093\/jas\/skaf036","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T08:42:03Z","timestamp":1739349723000},"source":"Crossref","is-referenced-by-count":8,"title":["Efficacy of supplemental amino acids with <i>Corynebacterium glutamicum<\/i> cell mass on growth and health of nursery pigs"],"prefix":"10.1093","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-9721","authenticated-orcid":false,"given":"Yi-Chi","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0094-336X","authenticated-orcid":false,"given":"Marcos Elias","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-1943","authenticated-orcid":false,"given":"Sung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"2025031808273510900_CIT0001","volume-title":"Official feed definitions","author":"AAFCO (Association of American Feed Control Officials)","year":"2008"},{"key":"2025031808273510900_CIT0002","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.3390\/ijms20071630","article-title":"Characterization of microbiota associated with digesta and mucosa in different regions of gastrointestinal tract of nursery pigs","volume":"20","author":"Adhikari","year":"2019","journal-title":"Int. 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