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This study analyzed the preventive and therapeutic effects of APS on chicks infected with Eimeria tenellaE. tenella and its impact on intestinal health. A total of 120 1-d-old Hy-Line Brown chicks were assigned to four groups (2\u2005\u00d7\u20052 factorial): 1) Control (0\u00a0mg\/L APS\u2005+\u20050 sporulated oocysts\/chick), 2) APS (1,000\u00a0mg\/L APS\u2005+\u20050 sporulated oocysts\/chick), 3) E. tenellaE. tenella (0\u00a0mg\/L APS\u2005+\u20055\u2005\u00d7\u2005104 sporulated oocysts\/chick), 4) E. tenella\u2005+\u2005APS (1,000\u00a0mg\/L APS\u2005+\u20055\u2005\u00d7\u2005104 sporulated oocysts\/chick). The results showed that the addition of APS to the drinking water increased the average daily gain and body weight (day 25) while reduced feed conversion ratio in E. tenella-infected chicks (P\u2005&amp;lt;\u20050.05). APS mitigated cecal lesions (P\u2005&amp;lt;\u20050.05), decreased oocyst shedding (P\u2005&amp;lt;\u20050.05), lowered spleen index (P\u2005&amp;lt;\u20050.05), and elevated bursa and thymus indices (P\u2005&amp;lt;\u20050.05). Serum total protein and alkaline phosphatase activity increased (P\u2005&amp;lt;\u20050.05). Cecal tissue mRNA expression of IL-2, IgG, IgM, Claudin1, Claudin2, ZO-1, and Occludin were increased (P\u2005&amp;lt;\u20050.05), whereas IL-1\u03b2, TNF-\u03b1, and NF-\u03baB were decreased (P\u2005&amp;lt;\u20050.05). APS enriched cecal f_Lactobacillaceae, g_Lactobacillus, g_Tuzzerella, g_Oscillospira, and g_UBA1819 (P\u2005&amp;lt;\u20050.05). Furthermore, the anticoccidial index (142.10) indicated low-level efficacy. In conclusion, APS alleviated E. tenella damage by modulating immunity, inflammation, microbiota, and intestinal barriers. Although APS demonstrated limited direct anticoccidial activity, its multifaceted protective effects suggest potential in the prevention and treatment of coccidiosis.<\/jats:p>","DOI":"10.1093\/jas\/skaf080","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T04:50:33Z","timestamp":1743051033000},"source":"Crossref","is-referenced-by-count":3,"title":["<i>Astragalus<\/i> polysaccharide mitigates <i>Eimeria tenella<\/i>-induced damage in laying chicks by modulating immunity, inflammation, and intestine barrier"],"prefix":"10.1093","volume":"103","author":[{"given":"Yi Yi","family":"Zhao","sequence":"first","affiliation":[{"name":"Henan International Joint Laboratory of Animal Welfare and Health Breeding, Henan University of Science and Technology , Luoyang ,","place":["PR China"]},{"name":"Yunnan Province Nutrition and Metabolic Diseases Research Laboratory, Yunnan Agricultural University , Kunming ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory of Animal Welfare and Health Breeding, Henan University of Science and Technology , Luoyang ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang Feng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Yunnan Province Nutrition and Metabolic Diseases Research Laboratory, Yunnan Agricultural University , Kunming ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing Qing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Yunnan Province Nutrition and Metabolic Diseases Research Laboratory, Yunnan Agricultural University , Kunming ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Bo","family":"Ma","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory of Animal Welfare and Health Breeding, Henan University of Science and Technology , Luoyang ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory of Animal Welfare and Health Breeding, Henan University of Science and Technology , Luoyang ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan Province Nutrition and Metabolic Diseases Research Laboratory, Yunnan Agricultural University , Kunming ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0918-6601","authenticated-orcid":false,"given":"Cai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory of Animal Welfare and Health Breeding, Henan University of Science and Technology , Luoyang ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,23]]},"reference":[{"key":"2025050306311332300_CIT0001","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3855\/jidc.10542","article-title":"Antimicrobial role of Lactobacillus species as potential probiotics against enteropathogenic bacteria in chickens","volume":"13","author":"Ahmed","year":"2019","journal-title":"J. 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