{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:49:22Z","timestamp":1789775362097,"version":"4.0.1"},"reference-count":61,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>During the weaning period, piglets suffer from various challenges induced by changed trophic conditions, unstable immune systems, and exposure to unfamiliar environments accompanied by direct or indirect production losses. Supplementation of probiotics in a nursery diet has been considered an effective strategy that improves the growth rate and gut health of pigs. In swine production, lactic acid-producing bacteria (LAB), including Lactobacilli, are commonly used as prominent probiotics. Thus, the objective of this study was to evaluate the effects of dietary Lacticaseibacillus rhamnosus (LR), one of the Lactobacilli probiotics, on growth performance, frequency of diarrhea, nutrient digestibility, gut health, and immune responses of weaned pigs. A total of 48 pigs (6.51\u2005\u00b1\u20050.87kg; 28 d old)\u00a0were allocated to 2 dietary treatments in a randomized complete block design (block: initial body weight). Dietary treatments were a basal nursery diet based on corn\u2013soybean meal (CON) and CON + 0.02% LR (IDCC 3201; 2\u2005\u00d7\u2005109 CFU\/g; Ildong Bioscience Co, Ltd, Seoul, Republic of Korea). The experiment was conducted for 4\u00a0wk. In this study, the LR group increased (P\u2005&amp;lt;\u20050.05) gain to feed ratio from d 1 to 7 compared with the CON group. Pigs fed LR had higher (P\u2005&amp;lt;\u20050.05) apparent total tract digestibility of dry matter, energy, and crude protein than those fed CON. The dietary LR decreased (P\u2005&amp;lt;\u20050.05) crypt depth in the duodenum and ileum compared with CON. The dietary LR upregulated ileal expression of the claudin-1 gene (P\u2005&amp;lt;\u20050.05) and tended to increase the claudin-2 gene (P\u2005=\u20050.089) while downregulated (P\u2005&amp;lt;\u20050.05) expression of tumor necrosis factor-\u03b1 and interleukin-8 genes compared with CON. The LR group decreased (P\u2005&amp;lt;\u20050.05) platelet count on d 14 compared with the CON group. Furthermore, pigs fed LR had lower serum concentrations of the tumor necrosis factor-\u03b1 on d 7 (P\u2005&amp;lt;\u20050.05) as well as interleukin-6 on d 7, 14, and 28 (P\u2005&amp;lt;\u20050.05) than those fed CON. This study suggests that the supplementation of 0.02% LR in the nursery diet can improve the growth performance and nutrient digestibility of weaned pigs by enhancing intestinal morphology, ileal gene expression of tight junction proteins and inflammatory cytokine, and systemic immune responses.<\/jats:p>","DOI":"10.1093\/jas\/skaf089","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T04:06:48Z","timestamp":1743221208000},"source":"Crossref","is-referenced-by-count":8,"title":["The potential probiotic role of <i>Lacticaseibacillus rhamnosus<\/i> on growth performance, gut health, and immune responses of weaned pigs"],"prefix":"10.1093","volume":"103","author":[{"given":"Ikcheol","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Animal Science and Biotechnology, Chungnam National University , Daejeon 34134 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3593-2656","authenticated-orcid":false,"given":"Yonggu","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, Chungnam National University , Daejeon 34134 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmu","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, Chungnam National University , Daejeon 34134 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, Chungnam National University , Daejeon 34134 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinuk","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, Chungnam National University , Daejeon 34134 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, Chungnam National University , Daejeon 34134 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6934-398X","authenticated-orcid":false,"given":"Jun-Mo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Technology, Chung-Ang University , Anseong 17546 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Bio-Integrated Science and Technology, College of Life Sciences, Sejong University , Seoul 05006 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungwoo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine, Dongguk University , Gyeongju 38066 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youghoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University , Seoul 08826 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangnam","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Functional Food and Biotechnology, Jeonju University , Jeonju 55069 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjee","family":"Lee","sequence":"additional","affiliation":[{"name":"IBS R&D Center, Ildong Bioscience. Pyeongtaek 17957 ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4515-5212","authenticated-orcid":false,"given":"Minho","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, Chungnam National University , Daejeon 34134 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5742-5374","authenticated-orcid":false,"given":"Hyunjin","family":"Kyoung","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology, Chungnam National University , Daejeon 34134 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,23]]},"reference":[{"key":"2025052207012714600_CIT0001","volume-title":"Official methods of analysis","author":"AOAC","year":"2006","edition":"18th ed"},{"key":"2025052207012714600_CIT0002","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3920\/BM2011.0041","article-title":"Lactobacillus acidophilus and Lactobacillus reuteri modulate cytokine responses in gnotobiotic pigs infected with human rotavirus","volume":"3","author":"Azevedo","year":"2012","journal-title":"Benef Microbes"},{"key":"2025052207012714600_CIT0003","first-page":"29","article-title":"The effect of Lactobacillus acidophilus and Bifidobacterium spp. administration on the morphology of the gastrointestinal tract, liver and pancreas in piglets","volume":"8","author":"Babinska","year":"2005","journal-title":"Pol. 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