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Acetylated high-amylose maize starch (HAMSA) delivers acetate to the large bowel and may reduce the severity of enteric infections, including those caused by Escherichia coli (E. coli). This study examined the effects of HAMSA and zinc oxide (ZnO) supplementation on PWD and performance in pigs experimentally inoculated with an F4 enterotoxigenic strain of E. coli (F4-ETEC). Seventy-two weaned pigs were divided into three dietary groups: 1) control (no antimicrobial compounds); 2) control plus 3,000\u00a0mg ZnO\/kg; and 3) control plus 50\u00a0g HAMSA\/kg. Pigs commenced diets on the day of weaning, were inoculated with an F4-ETEC strain on days 5 and 6, and were fed diets ad libitum for 21 days. The incidence of PWD (\u03c72\u2005=\u20050.035) and the diarrhea index (P\u2005=\u20050.032) were both lowest, commensurate with a lower plasma haptoglobin concentration (P\u2005=\u20050.010), in pigs fed ZnO than pigs fed other diets, despite there being a trend for an interaction (P\u2005=\u20050.088) in pigs fed HAMSA to have a lower F4 E. coli:total E. coli ratio on d 11 after weaning. Pigs fed ZnO and HAMSA grew faster (P\u2005=\u20050.009) and ate more (P\u2005=\u20050.048) in week 3 than control pigs. Overall, there was a trend (P\u2005=\u20050.065) for pigs fed the ZnO diet or HAMSA diet to eat ~ 20% more than those fed the control diet that resulted in a trend (P\u2005=\u20050.064) for ZnO- and HAMSA-fed pigs to weigh ~ 10% more than control-fed pigs at the end of the study. The HAMSA-fed pigs had a lower (P\u2005=\u20050.044) FCR in week 3, and overall (P\u2005=\u20050.003). Pigs fed HAMSA did not show any increase (P\u2005&amp;gt;\u20050.05) in their fecal short-chain fatty acid or acetate concentrations. The significant effect of HAMSA on FCR justifies further investigation as this may improve production efficiency in the post-weaning period following an enteric F4-ETEC infection.<\/jats:p>","DOI":"10.1093\/jas\/skaf181","type":"journal-article","created":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T13:19:24Z","timestamp":1748092764000},"source":"Crossref","is-referenced-by-count":0,"title":["A comparison of feeding acetylated high-amylose maize starch and zinc oxide in weaned pigs experimentally inoculated with an enterotoxigenic strain of <i>Escherichia coli<\/i>"],"prefix":"10.1093","volume":"103","author":[{"given":"Danica","family":"Evans","sequence":"first","affiliation":[{"name":"School of Agricultural Sciences, College of Environmental and Life Sciences, Murdoch University , Murdoch, Western Australia 6150,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethany","family":"Bowring","sequence":"additional","affiliation":[{"name":"Elizabeth Macarthur Agricultural Institute, New South Wales Department of Primary Industries , Menangle, New South Wales 2568,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1446-7985","authenticated-orcid":false,"given":"Alison","family":"Collins","sequence":"additional","affiliation":[{"name":"Elizabeth Macarthur Agricultural Institute, New South Wales Department of Primary Industries , Menangle, New South Wales 2568,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Clarke","sequence":"additional","affiliation":[{"name":"CSIRO Health and Biosecurity , Commonwealth Scientific and Industrial Research Organisation (CSIRO), Adelaide, South Australia,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Cheol","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Agricultural Sciences, College of Environmental and Life Sciences, Murdoch University , Murdoch, Western Australia 6150,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josie","family":"Mansfield","sequence":"additional","affiliation":[{"name":"School of Agricultural Sciences, College of Environmental and Life Sciences, Murdoch University , Murdoch, Western Australia 6150,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R","family":"Pluske","sequence":"additional","affiliation":[{"name":"School of Agricultural Sciences, College of Environmental and Life Sciences, Murdoch University , Murdoch, Western Australia 6150,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"key":"2025062700321135900_CIT0001","doi-asserted-by":"publisher","first-page":"3523","DOI":"10.1093\/jn\/133.11.3523","article-title":"Acetylated, propionylated or butyrylated starches raise large bowel short-chain fatty acids preferentially when fed to rats","volume":"133","author":"Annison","year":"2003","journal-title":"J. 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