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A total of 93 differentially expressed (DE) miRNAs were identified across all libraries, with the M8 vs. M10 group having the largest number (34 upregulated and 47 downregulated; |log\u2082 fold change|\u2005&amp;gt;\u20051, FDR\u2005&amp;lt;\u20050.05). These stage-specific DE miRNAs were clustered into four groups, with their target genes primarily enriched in signaling pathways such as Wnt, JAK-STAT, PI3K-Akt, VEGF, and steroid biosynthesis, which are important factors influencing ovarian cell activity, hormone secretion, angiogenesis, and embryonic development. Real-time quantitative polymerase chain reaction verification showed that the expression patterns of the 9 selected DE miRNAs were consistent with the sequencing data. Additionally, through the joint analysis of DE miRNAs and mRNAs, a co-expression network associated with ovarian reproductive function changes was constructed, ultimately highlighting 11 key miRNAs. Dual-luciferase reporter assays further confirmed the direct targeting relationships between core miR-432-5p and CPT1B, as well as miR-455-3p and PLXNB1. In summary, this study revealed the dynamic changes in ovarian miRNA expression profiles from pre-pregnancy to postpartum and their potential molecular mechanisms, providing theoretical support and key molecular targets for miRNAs in reproductive regulation, with significant implications for improving reproductive efficiency in livestock.<\/jats:p>","DOI":"10.1093\/jas\/skaf187","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T12:48:36Z","timestamp":1752238116000},"source":"Crossref","is-referenced-by-count":0,"title":["Dynamic microRNA expression profiles in goat ovarian tissues before and after pregnancy"],"prefix":"10.1093","volume":"103","author":[{"given":"Yanyan","family":"Wang","sequence":"first","affiliation":[{"name":"Shandong Provincial Key laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science and Veterinary Medicine, Shandong Agricultural University , Tai\u2019an City, Shandong Province 271014 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