{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:24:30Z","timestamp":1787009070000,"version":"build-2736575974"},"reference-count":54,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study investigated the precise alleviating mechanisms of Zn on chick embryonic jejunal epithelial cells under thermal stress (TS) and elucidated signaling pathways directly involved in this process. Experiment 1 identified the effective concentrations of inhibitors or agonists for extracellular regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK), and phosphatidylinositol 3-kinase\/protein kinase B (PI3K\/AKT). The data were analyzed using one-way ANOVA. In experiment 2, a randomized factorial design consisting of 3 controls\u2005+\u20053 cell types\u2005\u00d7\u20053 Zn treatments was used to confirm the effect of Zn and cell type on each signaling pathway. Under heat stress (HT, 44\u00b0C), 3 cell types in which the signaling pathways were normal, inhibited, or overexpressed were subjected to 3 treatments consisting of supplementation with inorganic Zn sulfate (iZn), organic Zn proteinate (oZn), or no Zn supplementation (containing 3.98 \u03bcmol Zn\/L). Under normal temperature (NT, 40 \u00b0C), the 3 cell types without Zn addition as controls. The significant differences between NT and HT across each cell type were conducted by T-test, data under HT were evaluated using two-way ANOVA. The results showed that TS decreased transepithelial resistance (TEER), claudin-1 and zona occludens-1 (ZO-1) mRNA levels, phosphorylated (p)-ERK\/ERK, p-PI3K\/PI3K, and p-AKT\/AKT levels, and increased phenol red permeability compared with NT in 3 cell types (P\u2005&amp;lt;\u20050.05). Under HT, iZn and oZn decreased phenol red permeability and diamine oxidase (DAO), while increasing cell proliferation, claudin-1, occludin, and junctional adhesion molecule-A (JAM-A) mRNA and p-ERK\/ERK level in normal cells, and the above mRNA levels were higher in the oZn group than in the iZn group (P\u2005&amp;lt;\u20050.05); however, different Zn treatments had no effect on DAO and cell proliferation in ERK inhibited and overexpression cells (P\u2005&amp;gt;\u20050.05). The interaction between cell type and Zn treatment did not affect the integrity and barrier function indices and p-JNK\/JNK level in the cells for the JNK signaling pathway (P\u2005&amp;gt;\u20050.05). Supplemental iZn and oZn increased TEER, cell proliferation, claudin-1 and p-PI3K\/PI3K level in normal cells (P\u2005&amp;lt;\u20050.05), but different Zn treatments had no effect on phenol red permeability, DAO and cell proliferation in PI3K\/AKT inhibited and over expression cells, and ZO-1 mRNA and protein levels and p-PI3K\/PI3K level in over expression cells (P\u2005&amp;gt;\u20050.05). Therefore, the above results show that Zn could alleviate TS-induced damage to the integrity and barrier function of chick embryonic jejunal epithelial cells via the ERK and PI3K\/AKT signaling pathways.<\/jats:p>","DOI":"10.1093\/jas\/skaf266","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T11:34:49Z","timestamp":1754393689000},"source":"Crossref","is-referenced-by-count":5,"title":["Roles of JNK, ERK, and PI3K\/AKT signaling pathways in zinc-mediated alleviation of thermal stress-induced damage to the integrity and barrier function of primary cultured chick jejunal epithelial cells"],"prefix":"10.1093","volume":"103","author":[{"given":"Liang","family":"Huang","sequence":"first","affiliation":[{"name":"Mineral Nutrition Research Division, State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193 ,","place":["China"]},{"name":"Institute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agricultural Sciences , Fuzhou 350013 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Cao","sequence":"additional","affiliation":[{"name":"Poultry Mineral Nutrition Laboratory, College of Animal Science and Technology, Yangzhou University , Yangzhou 225000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanxu","family":"Lin","sequence":"additional","affiliation":[{"name":"Mineral Nutrition Research Division, State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Poultry Mineral Nutrition Laboratory, College of Animal Science and Technology, Yangzhou University , Yangzhou 225000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao-Ching","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Odle","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles Todd","family":"See","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Mineral Nutrition Research Division, State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lu","sequence":"additional","affiliation":[{"name":"Mineral Nutrition Research Division, State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xugang","family":"Luo","sequence":"additional","affiliation":[{"name":"Poultry Mineral Nutrition Laboratory, College of Animal Science and Technology, Yangzhou University , Yangzhou 225000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiudong","family":"Liao","sequence":"additional","affiliation":[{"name":"Mineral Nutrition Research Division, State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences , Beijing 100193 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"2025082804314458500_CIT0001","doi-asserted-by":"publisher","first-page":"125","DOI":"10.5194\/aab-63-125-2020","article-title":"Effects of organic zinc on the performance and gut integrity of broilers under heat stress conditions","volume":"63","author":"Abuajamieh","year":"2020","journal-title":"Arch. 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