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Twelve Holstein steers (n\u2005=\u20056 per treatment) were enrolled in a randomized complete block design and blocked into 3 groups based on their initial body weight (BW: 294\u2005\u00b1\u200512.7\u00a0kg). Steers within each block were randomly assigned to 2 treatments: CON (Control, basal diet only), or SCFP (basal diet, top dressed with 12\u00a0g\/d SCFP, NaturSafe, Diamond V, Cedar Rapids, IA). The diet consisted of 20% corn silage and 80% concentrate on a DM basis. After 29 d, blood samples and the BW of each animal were collected, and animals were transferred to the headbox-style respiratory chamber. Following a 24-h adaptation, respiratory data were recorded for 48\u00a0h. The GLIMMIX procedure of SAS 9.4 and Metaboanalyst 6.0 were used to conduct data analyses. Overall dry matter intake (DMI) was greater (P\u2005=\u20050.05) in steers fed SCFP. Compared to the control, SCFP steers had greater DMI both during the 29-d feeding period (7.43 vs. 7.08\u00a0kg\/d) and during the respiratory measurement (6.58 vs. 5.45\u00a0kg\/d). Feeding SCFP did not affect total methane production per day (P\u2005=\u20050.91), per kg of metabolic BW (P\u2005=\u20050.94), or per kg of DMI (P\u2005=\u20050.46). Similarly, O2 consumption and CO2 production were unaffected (P\u2005\u2265\u20050.34 and 0.30, respectively). Supplementation of SCFP enriched plasma pathways of \u2018Ubiquinone and other terpenoid-quinone biosynthesis\u2019 (P\u2005=\u20050.02) and \u2018Phenylalanine, tyrosine, and tryptophan biosynthesis\u2019 (P\u2005=\u20050.03). In summary, SCFP improved intake and enriched metabolic pathways associated with protein and energy metabolism and may support antioxidant capacity without affecting methane emissions in steers fed high-concentrate diets.<\/jats:p>","DOI":"10.1093\/jas\/skaf307","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:45:27Z","timestamp":1756381527000},"source":"Crossref","is-referenced-by-count":1,"title":["Effects of <i>Saccharomyces cerevisiae<\/i> fermentation-derived postbiotic on methane production and plasma metabolome of fattening Holstein steers fed a high-grain diet"],"prefix":"10.1093","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8959-8293","authenticated-orcid":false,"given":"Anjan","family":"Dhungana","sequence":"first","affiliation":[{"name":"School of Agriculture and Natural Resources, Kentucky State University , Frankfort, KY, 40601 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwaseun A","family":"Odunfa","sequence":"additional","affiliation":[{"name":"School of Agriculture and Natural Resources, Kentucky State University , Frankfort, KY, 40601 ,","place":["USA"]},{"name":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison , Madison, WI, 53707 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Altman","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Sciences, University of Kentucky , Lexington, KY, 40546 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3875-6156","authenticated-orcid":false,"given":"Ibukun","family":"Ogunade","sequence":"additional","affiliation":[{"name":"Division of Animal and Nutritional Science, West Virginia University , Morgantown, WV, 26506 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle R","family":"McLeod","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Sciences, University of Kentucky , Lexington, KY, 40546 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkyu","family":"Yoon","sequence":"additional","affiliation":[{"name":"Diamond V , Cedar Rapids, IA, 52404 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L","family":"Harmon","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Sciences, University of Kentucky , Lexington, KY, 40546 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison , Madison, WI, 53707 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"key":"2025093003363253700_CIT0001","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.als.2016.11.006","article-title":"Sub-acute ruminal acidosis (SARA) and its consequence in dairy cattle: a review of past and recent research at global prospective","volume":"10","author":"Abdela","year":"2016","journal-title":"Achiev. 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