{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:45:23Z","timestamp":1792532723635,"version":"4.5.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":293,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Early lactation in dairy cows is characterized by negative energy balance and compromised immune function that could lead to metabolic or inflammatory diseases. Circulating biochemical blood variables are increasingly used as indicators of metabolic and inflammatory diseases in many species. This study aimed to estimate genetic parameters and identify candidate genes and quantitative trait loci (QTL) associated with serum proteins (total protein, albumin, globulin, and albumin-to-globulin ratio), liver enzymes (gamma-glutamyltransferase [GGT], aspartate-amino-transferase [AST], glutamate dehydrogenase [GLDH]) and other serum variables (glucose, urea, nonesterified fatty acids [NEFA], \u03b2-hydroxybutyric acid [BHBA], and cholesterol). The study population consisted of genotyped lactating Holsteins (938 cows with 80,709 single nucleotide polymorphisms [SNPs]) and serum concentrations of biochemical variables sampled at 2\u201314\u2009days in milk (DIM) from 11 commercial farms in Alberta. The heritability of the serum variables ranged from 0.04 to 0.35, with cholesterol the most heritable (0.35\u2009\u00b1\u20090.07), while both glucose and urea were the least heritable (0.04\u2009\u00b1\u20090.05). Strong genetic correlations were observed between NEFA and GGT (0.78\u2009\u00b1\u20090.34), AST (0.74\u2009\u00b1\u20090.29), and BHBA (0.70\u2009\u00b1\u20090.26). Genome-wide association studies (GWAS) identified 45 and 7 SNPs associated with GGT and cholesterol concentrations, respectively. Candidate genes and QTLs within 100\u2009kb up- and downstream of significant SNPs were detected for GGT and cholesterol. Multiple candidate genes and QTLs in the identified regions are implicated in pathways influencing metabolic disorders, production, and fertility in lactating dairy cows. Overall, the results showed low-to-moderate heritability and identified candidate genes and QTL regions associated with serum GGT and cholesterol. These results have potential utility in efforts to enhance the resilience of dairy cows through genetic selection.<\/jats:p>","DOI":"10.1093\/jas\/skaf359","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T12:10:06Z","timestamp":1760703006000},"source":"Crossref","is-referenced-by-count":3,"title":["Genetic parameters and QTL mapping for novel metabolic traits in early-lactation Holsteins"],"prefix":"10.1093","volume":"103","author":[{"given":"Rui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Agricultural, Food and Nutritional Science, University of Alberta , Edmonton, AB T6G 2P5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagnachew","family":"Hailemariam","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Nutritional Science, University of Alberta , Edmonton, AB T6G 2P5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Baes","sequence":"additional","affiliation":[{"name":"Centre for Genetic Improvement of Livestock, University of Guelph , Guelph, ON N1G 2W1,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Miglior","sequence":"additional","affiliation":[{"name":"Centre for Genetic Improvement of Livestock, University of Guelph , Guelph, ON N1G 2W1,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4263-969X","authenticated-orcid":false,"given":"Paul","family":"Stothard","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Nutritional Science, University of Alberta , Edmonton, AB T6G 2P5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7793-6515","authenticated-orcid":false,"given":"Marcos","family":"Colazo","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Nutritional Science, University of Alberta , Edmonton, AB T6G 2P5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3774-3110","authenticated-orcid":false,"given":"Graham","family":"Plastow","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Nutritional Science, University of Alberta , Edmonton, AB T6G 2P5,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"issue":"4","key":"2025111208420465700_skaf359-B1","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.meatsci.2014.07.030","article-title":"Genome wide association study of cholesterol and poly- and monounsaturated fatty acids, protein, and mineral content of beef from crossbred cattle","volume":"98","author":"Ahlberg","year":"2014","journal-title":"Meat Sci"},{"issue":"3","key":"2025111208420465700_skaf359-B2","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3168\/jds.s0022-0302(75)84582-6","article-title":"Genetic and environmental effects on serum cholesterol of dairy cattle of various ages","volume":"58","author":"Arave","year":"1975","journal-title":"J. Dairy Sci"},{"issue":"7","key":"2025111208420465700_skaf359-B3","doi-asserted-by":"publisher","first-page":"6354","DOI":"10.3168\/jds.2019-17916","article-title":"Heritability estimates of predicted blood \u03b2-hydroxybutyrate and nonesterified fatty acids and relationships with milk traits in early-lactation Holstein cows","volume":"103","author":"Benedet","year":"2020","journal-title":"J. Dairy Sci"},{"issue":"1","key":"2025111208420465700_skaf359-B4","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Series B Stat. Methodol"},{"issue":"9","key":"2025111208420465700_skaf359-B5","doi-asserted-by":"publisher","first-page":"3300","DOI":"10.3168\/jds.2008-0995","article-title":"Effects of inflammatory conditions on liver activity in puerperium period and consequences for performance in dairy cows","volume":"91","author":"Bertoni","year":"2008","journal-title":"J. Dairy Sci"},{"issue":"12","key":"2025111208420465700_skaf359-B6","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1017\/s1751731117001227","article-title":"Variation in blood serum proteins and association with somatic cell count in dairy cattle from multi-breed herds","volume":"11","author":"Bobbo","year":"2017","journal-title":"Animal"},{"issue":"10","key":"2025111208420465700_skaf359-B7","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1016\/j.ajhg.2021.08.005","article-title":"Fast two-stage phasing of large-scale sequence data","volume":"108","author":"Browning","year":"2021","journal-title":"Am. J. Hum. Genet"},{"issue":"1","key":"2025111208420465700_skaf359-B8","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1186\/1471-2164-15-1112","article-title":"Genome-wide association and biological pathway analysis for milk-fat composition in Danish holstein and Danish Jersey cattle","volume":"15","author":"Buitenhuis","year":"2014","journal-title":"BMC Genomics"},{"key":"2025111208420465700_skaf359-B9","volume-title":"Guidelines on the care and use of farm animals in research, teaching and testing","author":"Canadian Council on Animal Care","year":"2009"},{"issue":"7","key":"2025111208420465700_skaf359-B10","doi-asserted-by":"publisher","first-page":"8228","DOI":"10.3168\/jds.2020-19944","article-title":"Plasma albumin-to-globulin ratio before dry-off as a possible index of inflammatory status and performance in the subsequent lactation in dairy cows","volume":"104","author":"Cattaneo","year":"2021","journal-title":"J. Dairy Sci"},{"issue":"12","key":"2025111208420465700_skaf359-B11","doi-asserted-by":"publisher","first-page":"11108","DOI":"10.3168\/jds.2018-14907","article-title":"Genetic variation in serum protein pattern and blood \u03b2-hydroxybutyrate and their relationships with udder health traits, protein profile, and cheese-making properties in Holstein cows","volume":"101","author":"Cecchinato","year":"2018","journal-title":"J. Dairy Sci"},{"issue":"8","key":"2025111208420465700_skaf359-B12","doi-asserted-by":"publisher","first-page":"3895","DOI":"10.3168\/jds.2010-3687","article-title":"Short communication: reference values for blood parameters in Holstein dairy cows: effects of parity, stage of lactation, and season of production","volume":"94","author":"Cozzi","year":"2011","journal-title":"J. Dairy Sci"},{"issue":"12","key":"2025111208420465700_skaf359-B13","doi-asserted-by":"publisher","first-page":"11175","DOI":"10.3168\/jds.2018-15120","article-title":"Impaired hepatic autophagic activity in dairy cows with severe fatty liver is associated with inflammation and reduced liver function","volume":"101","author":"Du","year":"2018","journal-title":"J. Dairy Sci"},{"issue":"7","key":"2025111208420465700_skaf359-B14","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1534\/g3.115.018382","article-title":"Identification of reproduction-related gene polymorphisms using whole transcriptome sequencing in the Large White pig population","volume":"5","author":"Fischer","year":"2015","journal-title":"G3 (Bethesda)"},{"issue":"1","key":"2025111208420465700_skaf359-B15","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1186\/s12864-017-4308-z","article-title":"Genome-wide association studies of fertility and calving traits in Brown Swiss cattle using imputed whole-genome sequences","volume":"18","author":"Frischknecht","year":"2017","journal-title":"BMC Genomics"},{"issue":"1","key":"2025111208420465700_skaf359-B16","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/s12864-017-3638-1","article-title":"Analysis of hepatic transcript profile and plasma lipid profile in early lactating dairy cows fed grape seed and grape marc meal extract","volume":"18","author":"Gessner","year":"2017","journal-title":"BMC Genomics"},{"key":"2025111208420465700_skaf359-B17","volume-title":"ASReml user guide","author":"Gilmour","year":"2015"},{"key":"2025111208420465700_skaf359-B18","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.livsci.2019.05.016","article-title":"The factors associated with postpartum body condition score change and its relationship with serum analytes, milk production and reproductive performance in dairy cows","volume":"228","author":"Gobikrushanth","year":"2019","journal-title":"Livest. Sci"},{"issue":"4","key":"2025111208420465700_skaf359-B19","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.3168\/jds.2010-3707","article-title":"Performance and metabolic profile of dairy cows during a lactational and deliberately induced negative energy balance with subsequent realimentation","volume":"94","author":"Gross","year":"2011","journal-title":"J. Dairy Sci"},{"issue":"19","key":"2025111208420465700_skaf359-B21","doi-asserted-by":"publisher","first-page":"12560","DOI":"10.1074\/jbc.272.19.12560","article-title":"Mice with genetic \u03b3-glutamyl transpeptidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility","volume":"272","author":"Harding","year":"1997","journal-title":"J. Biol. Chem"},{"issue":"1\u20132","key":"2025111208420465700_skaf359-B22","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.tox.2008.09.016","article-title":"D-Dopachrome tautomerase is a candidate for key proteins to protect the rat liver damaged by carbon tetrachloride","volume":"255","author":"Hiyoshi","year":"2009","journal-title":"Toxicology"},{"issue":"D1","key":"2025111208420465700_skaf359-B23","doi-asserted-by":"publisher","first-page":"D956","DOI":"10.1093\/nar\/gkab1116","article-title":"Bringing the Animal QTLdb and CorrDB into the future: meeting new challenges and providing updated services","volume":"50","author":"Hu","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"2025111208420465700_skaf359-B24","doi-asserted-by":"publisher","first-page":"5878","DOI":"10.3168\/jds.2010-3391","article-title":"Associations of prepartum plasma cortisol, haptoglobin, fecal cortisol metabolites, and nonesterified fatty acids with postpartum health status in Holstein dairy cows","volume":"94","author":"Huzzey","year":"2011","journal-title":"J. Dairy Sci"},{"issue":"10","key":"2025111208420465700_skaf359-B25","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.3390\/genes12101495","article-title":"Genome-Wide association studies for milk somatic cell score in romanian dairy cattle","volume":"12","author":"Ilie","year":"2021","journal-title":"Genes (Basel)"},{"issue":"3","key":"2025111208420465700_skaf359-B26","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.3168\/jds.2015-10505","article-title":"Multiple-trait estimates of genetic parameters for metabolic disease traits, fertility disorders, and their predictors in Canadian Holsteins","volume":"99","author":"Jamrozik","year":"2016","journal-title":"J. Dairy Sci"},{"issue":"1","key":"2025111208420465700_skaf359-B27","doi-asserted-by":"publisher","first-page":"18998","DOI":"10.1038\/s41598-020-75870-4","article-title":"Genome wide association study of passive immunity and disease traits in beef-suckler and dairy calves on Irish farms","volume":"10","author":"Johnston","year":"2020","journal-title":"Sci. Rep"},{"issue":"12","key":"2025111208420465700_skaf359-B28","doi-asserted-by":"publisher","first-page":"475","DOI":"10.17221\/149\/2022-cjas","article-title":"General resilience in dairy cows: a review","volume":"67","author":"Ka\u0161n\u00e1","year":"2022","journal-title":"Czech J. Anim. Sci"},{"issue":"1","key":"2025111208420465700_skaf359-B29","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1186\/s12864-016-3374-y","article-title":"Potential immunosuppressive effects of Escherichia coli O157: H7 experimental infection on the bovine host","volume":"17","author":"Kieckens","year":"2016","journal-title":"BMC Genomics"},{"issue":"1","key":"2025111208420465700_skaf359-B20","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s12864-020-6520-5","article-title":"Identification of eQTLs and sQTLs associated with meat quality in beef","volume":"21","author":"Leal-Gutierrez","year":"2020","journal-title":"BMC Genomics"},{"issue":"11","key":"2025111208420465700_skaf359-B30","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.5713\/ajas.16.0310","article-title":"Genetic parameters of milk \u03b2-hydroxybutyric acid and acetone and their genetic association with milk production traits of Holstein cattle","volume":"29","author":"Lee","year":"2016","journal-title":"Asian-Australas. J. Anim. Sci"},{"issue":"12","key":"2025111208420465700_skaf359-B31","doi-asserted-by":"publisher","first-page":"11142","DOI":"10.3168\/jds.2019-17127","article-title":"Genomic prediction of serum biomarkers of health in early lactation","volume":"102","author":"Luke","year":"2019","journal-title":"J. Dairy Sci"},{"key":"2025111208420465700_skaf359-B32","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.theriogenology.2020.03.034","article-title":"Relationships between early postpartum nutritional and metabolic profiles and subsequent reproductive performance of lactating dairy cows","volume":"151","author":"Macmillan","year":"2020","journal-title":"Theriogenology"},{"issue":"8","key":"2025111208420465700_skaf359-B33","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1017\/s1751731120000439","article-title":"Genetic correlations between energy status indicator traits and female fertility in primiparous \u00adNordic Red Dairy cattle","volume":"14","author":"Mehti\u00f6","year":"2020","journal-title":"Animal"},{"issue":"4","key":"2025111208420465700_skaf359-B34","doi-asserted-by":"publisher","first-page":"534","DOI":"10.3390\/genes12040534","article-title":"Genetic regulation of biomarkers as stress proxies in dairy cows","volume":"12","author":"Milanesi","year":"2021","journal-title":"Genes (Basel)"},{"issue":"1","key":"2025111208420465700_skaf359-B35","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1038\/s42003-023-05413-w","article-title":"Evaluating 17 methods incorporating biological function with GWAS summary statistics to accelerate discovery demonstrates a tradeoff between high sensitivity and high positive predictive value","volume":"6","author":"Moore","year":"2023","journal-title":"Commun. Biol"},{"issue":"3","key":"2025111208420465700_skaf359-B36","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1080\/00288233.1998.9513319","article-title":"Genetics of susceptibility to facial eczema in Friesian and Jersey cattle","volume":"41","author":"Morris","year":"1998","journal-title":"N. Z. J. Agric. Res"},{"issue":"4","key":"2025111208420465700_skaf359-B37","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s00335-023-10021-4","article-title":"Comprehensive selection signature analyses in dairy cattle exploiting purebred and crossbred genomic data","volume":"34","author":"Nayak","year":"2023","journal-title":"Mamm. Genome"},{"issue":"5","key":"2025111208420465700_skaf359-B38","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3109\/00365513.2010.486442","article-title":"Biomarkers of alcohol consumption and related liver disease","volume":"70","author":"Niemel\u00e4","year":"2010","journal-title":"Scand. J. Clin. Lab. Invest"},{"issue":"7","key":"2025111208420465700_skaf359-B39","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.3168\/jds.2007-0965","article-title":"Genetic profile of body energy and blood metabolic traits across lactation in primiparous Holstein cows","volume":"91","author":"Oikonomou","year":"2008","journal-title":"J. Dairy Sci"},{"issue":"2","key":"2025111208420465700_skaf359-B40","doi-asserted-by":"publisher","first-page":"546","DOI":"10.3168\/jds.2009-2277","article-title":"Evaluation of nonesterified fatty acids and \u03b2-hydroxybutyrate in transition dairy cattle in the northeastern United States: critical thresholds for prediction of clinical diseases","volume":"93","author":"Ospina","year":"2010","journal-title":"J. Dairy Sci"},{"issue":"12","key":"2025111208420465700_skaf359-B41","doi-asserted-by":"publisher","first-page":"11004","DOI":"10.3168\/jds.2018-14413","article-title":"Genome-wide association study of milk fatty acid composition in Italian Simmental and Italian Holstein cows using single nucleotide polymorphism arrays","volume":"101","author":"Palombo","year":"2018","journal-title":"J. Dairy Sci"},{"issue":"11","key":"2025111208420465700_skaf359-B42","doi-asserted-by":"publisher","first-page":"9602","DOI":"10.3168\/jds.2023-24630","article-title":"Unraveling metabolic stress response in dairy cows: genetic control of plasma biomarkers throughout lactation and the transition period","volume":"107","author":"Passamonti","year":"2024","journal-title":"J. Dairy Sci"},{"issue":"3","key":"2025111208420465700_skaf359-B43","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.placenta.2011.12.005","article-title":"Variation in macrophage migration inhibitory factor [MIF] immunoreactivity during bovine gestation","volume":"33","author":"Paulesu","year":"2012","journal-title":"Placenta"},{"issue":"3","key":"2025111208420465700_skaf359-B44","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Human Genet"},{"issue":"11","key":"2025111208420465700_skaf359-B45","doi-asserted-by":"publisher","first-page":"7258","DOI":"10.3168\/jds.2014-8141","article-title":"Genome-wide association study using high-density single nucleotide polymorphism arrays and whole-genome sequences for clinical mastitis traits in dairy cattle","volume":"97","author":"Sahana","year":"2014","journal-title":"J. Dairy Sci"},{"key":"2025111208420465700_skaf359-B46","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.domaniend.2016.10.004","article-title":"Glucocorticoid metabolism in equine follicles and oocytes","volume":"59","author":"Scarlet","year":"2017","journal-title":"Domest. Anim. Endocrinol"},{"issue":"3","key":"2025111208420465700_skaf359-B47","doi-asserted-by":"publisher","first-page":"e0122317","DOI":"10.1371\/journal.pone.0122317","article-title":"Transition diseases in grazing dairy cows are related to serum cholesterol and other analytes","volume":"10","author":"Sep\u00falveda-Varas","year":"2015","journal-title":"PLoS One"},{"issue":"16","key":"2025111208420465700_skaf359-B48","doi-asserted-by":"publisher","first-page":"5389","DOI":"10.1128\/mcb.21.16.5389-5395.2001","article-title":"Disruption of \u03b3-glutamyl leukotrienase results in disruption of leukotriene D4 synthesis in vivo and attenuation of the acute inflammatory response","volume":"21","author":"Shi","year":"2001","journal-title":"Mol. Cell. Biol"},{"issue":"9","key":"2025111208420465700_skaf359-B49","doi-asserted-by":"publisher","first-page":"10076","DOI":"10.3168\/jds.2020-20101","article-title":"Genome-wide association study and functional analyses for clinical and subclinical ketosis in Holstein cattle","volume":"104","author":"Soares","year":"2021","journal-title":"J. Dairy Sci"},{"issue":"4","key":"2025111208420465700_skaf359-B50","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1071\/an09135","article-title":"A genome-wide association study of tick burden and milk composition in cattle","volume":"50","author":"Turner","year":"2010","journal-title":"Anim. Prod. Sci"},{"key":"2025111208420465700_skaf359-B51","doi-asserted-by":"publisher","first-page":"6781","DOI":"10.3168\/jds.2012-5640","article-title":"Genetic and nongenetic variation in plasma and milk \u03b2-hydroxybutyrate and milk acetone concentrations of early-lactation dairy cows","volume":"95","author":"van Der Drift","year":"2012","journal-title":"J. Dairy Sci"},{"issue":"3","key":"2025111208420465700_skaf359-B52","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.3168\/jds.2022-22951","article-title":"The Resilient Dairy Genome Project\u2014A general overview of methods and objectives related to feed efficiency and methane emissions","volume":"107","author":"van Staaveren","year":"2024","journal-title":"J. Dairy Sci"},{"key":"2025111208420465700_skaf359-B53","doi-asserted-by":"publisher","first-page":"103936","DOI":"10.1016\/j.livsci.2020.103936","article-title":"Genomic regions associated with principal components for growth, visual score and reproductive traits in nellore cattle","volume":"233","author":"Vargas","year":"2020","journal-title":"Livest. Sci"},{"issue":"8","key":"2025111208420465700_skaf359-B54","doi-asserted-by":"publisher","first-page":"861","DOI":"10.56093\/ijans.v89i8.93019","article-title":"Genome wide association study of test days and 305 days milk yield in crossbred cattle","volume":"89","author":"Wara","year":"2019","journal-title":"Indian J. Anim. Sci"},{"issue":"9","key":"2025111208420465700_skaf359-B55","doi-asserted-by":"publisher","first-page":"5670","DOI":"10.3168\/jds.2012-6277","article-title":"Hepatic gene expression involved in glucose and lipid metabolism in transition cows: effects of fat mobilization during early lactation in relation to milk performance and metabolic changes","volume":"96","author":"Weber","year":"2013","journal-title":"J. Dairy Sci"},{"issue":"2","key":"2025111208420465700_skaf359-B56","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1530\/joe-17-0066","article-title":"Hepatic thyroid signaling of heat-stressed late pregnant and early lactating cows","volume":"234","author":"Weitzel","year":"2017","journal-title":"J. Endocrinol"},{"issue":"1","key":"2025111208420465700_skaf359-B57","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s12943-019-1074-3","article-title":"The role of exosomal PD-L1 in tumor progression and immunotherapy","volume":"18","author":"Xie","year":"2019","journal-title":"Mol. Cancer"},{"issue":"2","key":"2025111208420465700_skaf359-B58","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/ng.2876","article-title":"Advantages and pitfalls in the application of mixed-model association methods","volume":"46","author":"Yang","year":"2014","journal-title":"Nat. Genet"},{"issue":"7","key":"2025111208420465700_skaf359-B59","doi-asserted-by":"publisher","first-page":"4772","DOI":"10.3168\/jds.2023-24345","article-title":"Genetic background of hematological parameters in Holstein cattle based on genome-wide association and RNA sequencing analyses","volume":"107","author":"Yang","year":"2024","journal-title":"J. Dairy Sci"},{"key":"2025111208420465700_skaf359-B60","doi-asserted-by":"publisher","first-page":"106696","DOI":"10.1016\/j.anireprosci.2021.106696","article-title":"Analysis of novel embryonic factors of cattle and effects on endometrial cells in vitro","volume":"226","author":"Yun","year":"2021","journal-title":"Anim. Reprod. Sci"},{"issue":"9","key":"2025111208420465700_skaf359-B61","doi-asserted-by":"publisher","first-page":"7289","DOI":"10.3168\/jds.2015-10697","article-title":"Genome-wide association study for longevity with whole-genome sequencing in 3 cattle breeds","volume":"99","author":"Zhang","year":"2016","journal-title":"J. Dairy Sci"}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jas\/advance-article-pdf\/doi\/10.1093\/jas\/skaf359\/64829207\/skaf359.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/doi\/10.1093\/jas\/skaf359\/64829207\/skaf359.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/doi\/10.1093\/jas\/skaf359\/64829207\/skaf359.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:42:13Z","timestamp":1762954933000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/doi\/10.1093\/jas\/skaf359\/8294144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":61,"URL":"https:\/\/doi.org\/10.1093\/jas\/skaf359","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025]]},"published":{"date-parts":[[2025]]},"article-number":"skaf359"}}