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Dietary restrictions may affect fetal testis development and the offspring fertility. Several studies have connected genetic instability to circadian cycle disruptions, including epigenetic modifications to melatonin, a key regulator. On day 160 of gestation, 17 male-bearing Brangus heifers were assigned to one of four groups in a 2 \u00d7 2 factorial treatment arrangement: adequately fed (ADQ; 100% NRC recommendation, n\u2009=\u20093), nutrient restricted (RES; 60% NRC recommendation, n\u2009=\u20095), or ADQ or RES supplemented with 20\u2009mg\/d melatonin (ADQ-MEL, n\u2009=\u20095; RES-MEL, n\u2009=\u20094). On day 240 of gestation, heifers underwent Cesarean sections to collect fetuses and testicular tissues. The fetal testicular tissue was processed and analyzed using the Methyl-MiniSeq Service: Genome-wide bisulfite sequencing (Methyl MiniSeq-GWBS). Sequence reads from Methyl Mini-Seq libraries were identified using standard Illumina platform calling software for methylome profile. RNA-Seq libraries were then sequenced on the Illumina platform for transcriptome profile. The common genes between differentially methylated regions (DMRs) and differentially expressed genes (DEGs) across different treatment groups were identified by an overlap analysis using bedtools v2.31.1. There were 413 DMRs in RES-CON and ADQ-CON testicular tissues, without differential gene expression. Compared with the ADQ-CON group, the ADQ-MEL group showed 411 DMRs and a higher KYAT1 gene expression (P-adj &amp;lt;0.05) without methylation changes. Comparing RES-MEL with RES-CON showed that 9 genes (DAAM1, COL28A1, RPL10, TRPM3, SLIT, ARHGEF40, SYT1, TMEM35B, CSPG4B) were expressed more in the former (P-adj &amp;lt;0.05). The only hypomethylated gene was DAAM1 located on chromosome 10. However, 13 genes (PTPRU, snRNP-E, TMEM59L, MUC5B, ANAPC15, FAM221A, SHCBPiL, PAQR5, PPP4R3C, DTNB, LncRNA, SHANK2, RIC3) showed increased expression in RES-CON vs. RES-MEL without differential methylation alterations, yet there were 370 DMRs. Five genes showed increased expression in RES-MEL compared with ADQ-MEL (P-adj &amp;lt;0.05), including histone H2B on chromosome 23. Two genes (PTPRU, TDRD10) showed increased expression in ADQ-MEL compared with RES-MEL (P-adj &amp;lt;0.05) without affecting methylation and 344 DMRs. In conclusion, dietary melatonin supplementation to nutrient restricted dams may influence fetal development as epigenomic and transcriptomic regulators are altered.<\/jats:p>","DOI":"10.1093\/jas\/skaf455","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:44:59Z","timestamp":1767789899000},"source":"Crossref","is-referenced-by-count":1,"title":["Integrated fetal testicular transcriptomic and epigenomic profiles during maternal nutrient restriction with dietary melatonin intervention"],"prefix":"10.1093","volume":"104","author":[{"given":"Hala","family":"El Daous","sequence":"first","affiliation":[{"name":"Department of Animal and Dairy Sciences, Mississippi State University , Mississippi State, MS, 39762"},{"name":"Faculty of Veterinary Medicine, Benha University , Mushtuhur, Qalioubia, 13736,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittni P","family":"Littlejohn","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Division of Agriculture, University of Arkansas , Fayetteville, AR, 72701"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2653-0336","authenticated-orcid":false,"given":"Zully E","family":"Contreras-Correa","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Tarleton State University , Stephenville, TX, 76402"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiveeli","family":"Rajput","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, Mississippi State University , Mississippi State, MS, 39762"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darcie R","family":"Sidelinger","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Medicine, Mississippi State University College of Veterinary Medicine , Mississippi State, MS, 39762"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E Heath","family":"King","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Medicine, Mississippi State University College of Veterinary Medicine , Mississippi State, MS, 39762"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Arick","sequence":"additional","affiliation":[{"name":"Institute for Genomics, Biocomputing and Biotechnology, Mississippi State University , Mississippi State, MS, 39762"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1377-0664","authenticated-orcid":false,"given":"Caleb O","family":"Lemley","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, Mississippi State University , Mississippi State, MS, 39762"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"issue":"1","key":"2026012811075701100_skaf455-B1","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ydbio.2015.10.003","article-title":"DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly","volume":"408","author":"Ajima","year":"2015","journal-title":"Dev. 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