{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:17:46Z","timestamp":1770337066745,"version":"3.49.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The current study was conducted to characterize metabolomic plasma profiles among sows differing in their lifetime born alive and lifetime weaned after four parities. Plasma samples were collected at harvest between 12 and 15\u2009d (luteal phase) following their fourth parity post-weaning estrus from 120 dams with consistent born alive and weaned at every farrowing event. Categories were derived as follows for average lifetime born alive (ba): High (H; 61ba), Mid (M; 50ba), and Low (L; 39ba) and raised (wn): High (H; 50wn) and Low (L; 34wn) generating 6 categories with 20 dams in each: HH, HL, MH, ML, LH, and LL, respective to born alive: raised. Plasma samples were submitted for ultra-performance liquid chromatography (positive and negative ionization modes)\u2014mass spectrometry (UPLC-MS) to isolate putative compounds. Analysis of variance with a false discovery correction was performed to determine categorical differences of putative compounds. Negative mode ionization UPLC-MS yielded 92 compounds different (P\u2009&amp;lt;\u20090.05) by category, while positive ionization mode provided 644 compounds different (P\u2009&amp;lt;\u20090.05) by category. Twenty-five putative compounds were different (P\u2009&amp;lt;\u20090.05) for the LL and ML categories vs. the HH and MH categories. A putative unique secondary bacterial compound structurally similar to saponins, MK-800-62F1, and an annotated fatty acid, lignoceroylsphingosine, were increased (P\u2009&amp;lt;\u20090.05) in HH dams. Several possible fatty acid, eicosanoid, and steroid compounds had greater (P\u2009&amp;lt;\u20090.05) intensities in LL and LH dams. Several annotated eicosanoid compounds, leukotriene B4, 5(S)-HETE, 15(S)-Hpete, and a PGF1\u03b1 product, can be biosynthesized in blood in response to an inflammatory stimulus. Probable steroid compounds had increased signal intensity in plasma from LL and LH dams, including neuroactive steroids such as corticosteroids and allopregnanolone and suggested derivatives of testosterone and progesterone steroid compounds. Characterization of plasma profiles among post fourth parity dams with differing lifetime born-alive and weaned production traits suggested unique features that may be related to various physiological systems, including immunological, metabolic, and hormonal. Future work verifying compounds and validating them in adolescent females may provide suitable predictors of lifetime production traits.<\/jats:p>","DOI":"10.1093\/jas\/skag003","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T12:42:45Z","timestamp":1767876165000},"source":"Crossref","is-referenced-by-count":0,"title":["Nontargeted plasma metabolomics associated with sow lifetime productivity traits"],"prefix":"10.1093","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8344-5085","authenticated-orcid":false,"given":"Lea A","family":"Rempel","sequence":"first","affiliation":[{"name":"USDA, ARS, USMARC , Clay Center, NE 68933"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan J","family":"Nonneman","sequence":"additional","affiliation":[{"name":"USDA, ARS, USMARC , Clay Center, NE 68933"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"issue":"1","key":"2026020506282501700_skag003-B1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13028-016-0213-8","article-title":"Impact of litter size on sow stayability in Swedish commercial piglet producing herds","volume":"58","author":"Andersson","year":"2016","journal-title":"Acta Vet. Scand"},{"issue":"6","key":"2026020506282501700_skag003-B2","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1080\/1040841X.2020.1828816","article-title":"Diverse endophytic streptomyces species with dynamic metabolites and their meritorious applications: a critical review","volume":"46","author":"Ayswaria","year":"2020","journal-title":"Crit. Rev. Microbiol"},{"issue":"1","key":"2026020506282501700_skag003-B3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B Methodol"},{"issue":"6885","key":"2026020506282501700_skag003-B4","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/417141a","article-title":"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)","volume":"417","author":"Bentley","year":"2002","journal-title":"Nature"},{"key":"2026020506282501700_skag003-B5","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.prevetmed.2018.08.010","article-title":"Sow removal in commercial herds: patterns and animal level factors in Finland","volume":"159","author":"Bergman","year":"2018","journal-title":"Prev. Vet. Med"},{"issue":"3","key":"2026020506282501700_skag003-B6","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1530\/REP-13-0142","article-title":"Differences in the metabolomic signatures of porcine follicular fluid collected from environments associated with good and poor oocyte quality","volume":"146","author":"Bertoldo","year":"2013","journal-title":"Reproduction"},{"issue":"10","key":"2026020506282501700_skag003-B7","doi-asserted-by":"publisher","first-page":"6631","DOI":"10.3168\/jds.2015-9683","article-title":"Invited review: inflammation during the transition to lactation: New adventures with an old flame","volume":"98","author":"Bradford","year":"2015","journal-title":"J. Dairy Sci"},{"issue":"14","key":"2026020506282501700_skag003-B8","doi-asserted-by":"publisher","first-page":"6812","DOI":"10.1021\/ac501530d","article-title":"RAMClust: a novel feature clustering method enables spectral-matching-based annotation for metabolomics data","volume":"86","author":"Broeckling","year":"2014","journal-title":"Anal. Chem"},{"issue":"4","key":"2026020506282501700_skag003-B9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5923\/j.fph.20120204.04","article-title":"Chemical characterization and stability of the bombacopsis glabra nut oil","volume":"2","author":"Chaves","year":"2012","journal-title":"Food Public Health"},{"key":"2026020506282501700_skag003-B10","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jprot.2019.03.015","article-title":"Metabolic disorder of amino acids, fatty acids and purines reflects the decreases in oocyte quality and potential in sows","volume":"200","author":"Chen","year":"2019","journal-title":"J. Proteomics"},{"issue":"1","key":"2026020506282501700_skag003-B11","first-page":"13","article-title":"Corticoids modulate FSH action in cultured porcine granulosa cells","volume":"21","author":"Danisova","year":"1987","journal-title":"Endocrinol Exp"},{"key":"2026020506282501700_skag003-B12","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13321-016-0174-y","article-title":"ClassyFire: automated chemical classification with a comprehensive, computable taxonomy","volume":"8","author":"Djoumbou Feunang","year":"2016","journal-title":"J. Cheminform"},{"key":"2026020506282501700_skag003-B13","first-page":"31","article-title":"Stearoyl-CoA desaturase\u2014a new player in skeletal muscle metabolism regulation","volume":"57 Suppl 10","author":"Dobrzyn","year":"2006","journal-title":"J Physiol Pharmacol"},{"key":"2026020506282501700_skag003-B14","author":"El-Naggar","year":"2021"},{"issue":"11","key":"2026020506282501700_skag003-B15","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.3390\/metabo12111045","article-title":"Identification of candidate salivary, urinary and serum metabolic biomarkers for high litter size potential in sows (Sus scrofa)","volume":"12","author":"Fletcher","year":"2022","journal-title":"Metabolites"},{"issue":"10","key":"2026020506282501700_skag003-B16","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/S2213-8587(14)70146-9","article-title":"Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study","volume":"2","author":"Forouhi","year":"2014","journal-title":"Lancet. Diabetes Endocrinol"},{"issue":"3","key":"2026020506282501700_skag003-B17","doi-asserted-by":"publisher","first-page":"e000889","DOI":"10.1161\/JAHA.114.000889","article-title":"Plasma phospholipid saturated fatty acids and incident atrial fibrillation: the cardiovascular health study","volume":"3","author":"Fretts","year":"2014","journal-title":"J. Am. Heart Assoc"},{"issue":"3","key":"2026020506282501700_skag003-B18","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1530\/eje.0.1330375","article-title":"Evidence for a role for the neurosteroid allopregnanolone in the modulation of reproductive function in female rats","volume":"133","author":"Genazzani","year":"1995","journal-title":"Eur. J. Endocrinol"},{"key":"2026020506282501700_skag003-B19","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1146\/annurev.mi.37.100183.001201","article-title":"Ecology of actinomycetes","volume":"37","author":"Goodfellow","year":"1983","journal-title":"Annu. Rev. Microbiol"},{"issue":"2","key":"2026020506282501700_skag003-B20","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.taap.2007.07.013","article-title":"Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds","volume":"225","author":"Gracia","year":"2007","journal-title":"Toxicol. Appl. Pharmacol"},{"issue":"5","key":"2026020506282501700_skag003-B21","doi-asserted-by":"crossref","first-page":"238","DOI":"10.54846\/jshap\/994","article-title":"An economic analysis of sow retention in a United States breed-to-wean system","volume":"25","author":"Gruhot","year":"2017","journal-title":"JSHAP"},{"issue":"8","key":"2026020506282501700_skag003-B22","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1039\/c4mb00054d","article-title":"A metabolomics approach for predicting the response to neoadjuvant chemotherapy in cervical cancer patients","volume":"10","author":"Hou","year":"2014","journal-title":"Mol. Biosyst"},{"issue":"5","key":"2026020506282501700_skag003-B23","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/nbt820","article-title":"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis","volume":"21","author":"Ikeda","year":"2003","journal-title":"Nat. Biotechnol"},{"issue":"7","key":"2026020506282501700_skag003-B24","doi-asserted-by":"publisher","first-page":"e245","DOI":"10.1038\/emm.2016.81","article-title":"Regulation and function of AMPK in physiology and diseases","volume":"48","author":"Jeon","year":"2016","journal-title":"Exp. Mol. Med"},{"issue":"4","key":"2026020506282501700_skag003-B25","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1262\/jrd.2016-128","article-title":"Administration of gonadotropin-releasing hormone agonist on day 5 increases luteal blood flow and improves pregnancy prediction accuracy on day 14 in recipient holstein cows","volume":"63","author":"Kanazawa","year":"2017","journal-title":"J. Reprod. Dev"},{"issue":"8","key":"2026020506282501700_skag003-B26","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.exger.2008.05.002","article-title":"A role of phosphatidylserine externalization in clearance of erythrocytes exposed to stress but not in eliminating aging populations of erythrocyte in mice","volume":"43","author":"Khandelwal","year":"2008","journal-title":"Exp. Gerontol"},{"issue":"1","key":"2026020506282501700_skag003-B27","doi-asserted-by":"publisher","first-page":"e21177","DOI":"10.1096\/fj.202001802R","article-title":"Phosphatidylserine biosynthesis pathways in lipid homeostasis: toward resolution of the pending Central issue for decades","volume":"35","author":"Kimura","year":"2021","journal-title":"Faseb J"},{"key":"2026020506282501700_skag003-B28","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40813-020-00163-1","article-title":"Farm data analysis for lifetime performance components of sows and their predictors in breeding herds","volume":"6","author":"Koketsu","year":"2020","journal-title":"Porcine Health Manag"},{"issue":"2","key":"2026020506282501700_skag003-B29","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1159\/000353694","article-title":"Leukotriene B4, an endogenous stimulator of the innate immune response against pathogens","volume":"6","author":"Le Bel","year":"2014","journal-title":"J. Innate Immun"},{"key":"2026020506282501700_skag003-B30","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.cca.2020.10.005","article-title":"Ceramides improve atherosclerotic cardiovascular disease risk assessment beyond standard risk factors","volume":"511","author":"Meeusen","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"2026020506282501700_skag003-B31","author":"MetaFarms"},{"issue":"9","key":"2026020506282501700_skag003-B32","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3390\/biom9090433","article-title":"Fusaricidin-Type compounds create pores in mitochondrial and plasma membranes of mammalian cells","volume":"9","author":"Mikkola","year":"2019","journal-title":"Biomolecules"},{"issue":"8","key":"2026020506282501700_skag003-B33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jas\/skab189","article-title":"Biomarkers predictive of long-term fertility found in vaginal lipidome of gilts at weaning","volume":"99","author":"Mills","year":"2021","journal-title":"J. Anim. Sci"},{"issue":"11","key":"2026020506282501700_skag003-B34","doi-asserted-by":"publisher","first-page":"5512","DOI":"10.1210\/en.2012-1414","article-title":"Periovulatory expression of hydrogen peroxide-induced sulfiredoxin and peroxiredoxin 2 in the rat ovary: gonadotropin regulation and potential modification","volume":"153","author":"Park","year":"2012","journal-title":"Endocrinology"},{"key":"2026020506282501700_skag003-B35","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.metabol.2017.01.034","article-title":"Obesity is positively associated with arachidonic acid-derived 5- and 11-hydroxyeicosatetraenoic acid (HETE)","volume":"70","author":"Pickens","year":"2017","journal-title":"Metabolism"},{"issue":"10","key":"2026020506282501700_skag003-B36","doi-asserted-by":"publisher","first-page":"4553","DOI":"10.1073\/pnas.88.10.4553","article-title":"Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain","volume":"88","author":"Purdy","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026020506282501700_skag003-B37","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3389\/fmolb.2016.00077","article-title":"Non-targeted plasma metabolome of early and late lactation gilts","volume":"3","author":"Rempel","year":"2016","journal-title":"Front. Mol. Biosci"},{"key":"2026020506282501700_skag003-B38","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.livsci.2015.05.036","article-title":"Measurements of body composition during late gestation and lactation in first and second parity sows and its relationship to piglet production and post-weaning reproductive performance","volume":"178","author":"Rempel","year":"2015","journal-title":"Livest. Sci"},{"issue":"2","key":"2026020506282501700_skag003-B39","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1093\/jas\/skx066","article-title":"Characterization of plasma metabolites at late gestation and lactation in early parity sows on production and post-weaning reproductive performance","volume":"96","author":"Rempel","year":"2018","journal-title":"J. Anim. Sci"},{"issue":"9","key":"2026020506282501700_skag003-B40","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.2527\/jas.2005-635","article-title":"Impact of biological and economic variables on optimal parity for replacement in swine breed-to-wean herds","volume":"84","author":"Rodriguez-Zas","year":"2006","journal-title":"J. Anim. Sci"},{"issue":"2","key":"2026020506282501700_skag003-B41","doi-asserted-by":"publisher","first-page":"123","DOI":"10.2174\/1871523019666200512114210","article-title":"Dietary technologies to optimize healing from Injury-Induced inflammation","volume":"20","author":"Sears","year":"2021","journal-title":"Antiinflamm. Antiallergy. Agents Med. Chem"},{"issue":"3","key":"2026020506282501700_skag003-B42","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1021\/ac051437y","article-title":"XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification","volume":"78","author":"Smith","year":"2006","journal-title":"Anal. Chem"},{"issue":"1","key":"2026020506282501700_skag003-B43","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cmet.2013.10.006","article-title":"Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases","volume":"19","author":"Spite","year":"2014","journal-title":"Cell Metab"},{"issue":"2","key":"2026020506282501700_skag003-B44","doi-asserted-by":"crossref","first-page":"69","DOI":"10.54846\/jshap\/357","article-title":"Financial impact of average parity of culled females in a breed-to-wean swine operation using replacement gilt net present value analysis","volume":"11","author":"Stalder","year":"2003","journal-title":"JSHAP"},{"issue":"1","key":"2026020506282501700_skag003-B45","doi-asserted-by":"publisher","first-page":"e12916","DOI":"10.1111\/jne.12916","article-title":"Effects of prenatal stress on neuroactive steroid responses to acute stress in adult male and female rats","volume":"33","author":"Sze","year":"2021","journal-title":"J. Neuroendocrinol"},{"key":"2026020506282501700_skag003-B46","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1186\/1471-2105-9-504","article-title":"Highly sensitive feature detection for high resolution LC\/MS","volume":"9","author":"Tautenhahn","year":"2008","journal-title":"BMC Bioinform"},{"key":"2026020506282501700_skag003-B47","year":"2013"},{"issue":"3","key":"2026020506282501700_skag003-B48","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0022-3565(25)24172-6","article-title":"Steroid anesthetics and naturally occurring analogs modulate the gamma-aminobutyric acid receptor complex at a site distinct from barbiturates","volume":"248","author":"Turner","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"2026020506282501700_skag003-B49","author":"USDA, National Agricultural Statistics Service","year":"2025"},{"issue":"4","key":"2026020506282501700_skag003-B50","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1161\/ATVBAHA.120.315530","article-title":"Ceramide scores predict cardiovascular risk in the community","volume":"41","author":"Vasile","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"2026020506282501700_skag003-B51","doi-asserted-by":"publisher","first-page":"997403","DOI":"10.3389\/fphar.2022.997403","article-title":"Eicosanoids in inflammation in the blood and the vessel","volume":"13","author":"Yamaguchi","year":"2022","journal-title":"Front. Pharmacol"},{"issue":"3","key":"2026020506282501700_skag003-B52","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1055\/s-2006-957871","article-title":"Prevention of hydrogen peroxide damage by soybean saponins to mouse fibroblasts","volume":"62","author":"Yoshikoshi","year":"1996","journal-title":"Planta Med"},{"issue":"6","key":"2026020506282501700_skag003-B53","doi-asserted-by":"publisher","first-page":"569","DOI":"10.7164\/antibiotics.53.569","article-title":"MK800-62F1, a new inhibitor of apoptotic cell death, from Streptomyces diastatochromogenes MK800-62F1. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity","volume":"53","author":"Yoshimoto","year":"2000","journal-title":"J Antibiot (Tokyo)"},{"issue":"6","key":"2026020506282501700_skag003-B54","doi-asserted-by":"publisher","first-page":"575","DOI":"10.7164\/antibiotics.53.575","article-title":"MK800-62F1, a new inhibitor of apoptotic cell death, from Streptomyces diastatochromogenes MK800-62F1. II. Structure elucidation","volume":"53","author":"Yoshimoto","year":"2000","journal-title":"J Antibiot (Tokyo)"},{"issue":"2","key":"2026020506282501700_skag003-B55","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1177\/1087057109356208","article-title":"A multiplexed cell assay in HepG2 cells for the identification of Delta-5, Delta-6, and Delta-9 desaturase and elongase inhibitors","volume":"15","author":"Zhang","year":"2010","journal-title":"J. Biomol. Screen"}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jas\/advance-article-pdf\/doi\/10.1093\/jas\/skag003\/66327161\/skag003.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/doi\/10.1093\/jas\/skag003\/66327161\/skag003.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/doi\/10.1093\/jas\/skag003\/66327161\/skag003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:28:36Z","timestamp":1770290916000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/doi\/10.1093\/jas\/skag003\/8418391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":55,"URL":"https:\/\/doi.org\/10.1093\/jas\/skag003","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"skag003"}}