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Forty-eight Angus crossbred steers (469\u2009\u00b1\u200931\u2009kg) were enrolled in a 77-day finishing study, housed in pens of six, with a GrowSafe bunk (GrowSafe Systems, Ltd, Airdrie, AB, Canada) in each pen and implanted (Revalor-200, Merck Animal Health, Madison, NJ; 200\u2009mg TBA + 20\u2009mg E2) on day 0. A 2\u2009\u00d7\u20092 factorial arrangement was applied to Cu status (Cu0, no supplemental Cu; or Cu10, 10\u2009mg supplemental Cu\/kg DM as CuSO4) and LUB (36\u2009mg\/steer\/day, LUB; or no LUB, NOLUB). A prior trial resulted in steers with distinct liver Cu (Cu0 and Cu10 were 42\u2009\u00b1\u200921 and 193\u2009\u00b1\u200931\u2009mg Cu\/kg DM, respectively). Lubabegron was fed from day 37 to day 73, and cattle harvested on day 78. Weights were collected on days \u22121, 0, 37, 55 (mid-Experior), 76, and 77. Blood was collected on days 0, 37, 55, and 76 for non-esterified fatty acids (NEFA), glucose, and insulin. Subcutaneous adipose biopsies were collected on days 0, 37, and 66. Data were analyzed using the MIXED procedure of SAS as a factorial design, with steer as the experimental unit (n\u2009=\u200912 per treatment). From days 0\u201337, Cu0 daily gain and feed efficiency (G: F) were greater than Cu10 (P\u2009&amp;lt;\u20090.01). Overall DMI was greater in Cu10 than Cu0 (P\u2009=\u20090.04) and not affected by LUB (P\u2009=\u20090.13). Carcass-adjusted average daily gain was greater in LUB-fed cattle (P\u2009=\u20090.04). During the LUB period, G: F was affected by Cu \u00d7 LUB (P\u2009=\u20090.04), where Cu0 cattle exhibited a greater improvement in efficiency due to LUB than Cu10. The revised quantitative insulin sensitivity check index displayed a LUB \u00d7 Day effect (P\u2009&amp;lt;\u20090.01) where NOLUB was consistent across days and LUB had greater insulin sensitivity during the LUB period. Populations of mononuclear phagocytes were greater in Cu0-LUB over all other treatments (LUB \u00d7 Cu P\u2009=\u20090.02). These data suggest Cu concentration influences steer response to lubabegron fumarate, highlighting the need for further research to optimize Cu supplementation to finishing cattle.<\/jats:p>","DOI":"10.1093\/jas\/skag047","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T12:41:26Z","timestamp":1771072886000},"source":"Crossref","is-referenced-by-count":1,"title":["The impact of copper status on lubabegron fumarate-induced growth and adipose immune cell infiltration in beef feedlot steers"],"prefix":"10.1093","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7362-7187","authenticated-orcid":false,"given":"Jacob A","family":"Henderson","sequence":"first","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7637-1455","authenticated-orcid":false,"given":"Jodi L","family":"McGill","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology and Preventative Medicine, Iowa State University , Ames, IA 50011,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5188-5078","authenticated-orcid":false,"given":"Stephanie L","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"2026031509061714600_skag047-B1","doi-asserted-by":"publisher","first-page":"3336","DOI":"10.1182\/BLOOD.V87.8.3336.BLOODJOURNAL8783336","article-title":"Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor 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