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Twenty-eight pregnant ewes were randomly assigned to either shorn (S) or sham-shorn control (CON) treatments on day 50 of gestation and stratified by fetal number as singleton (S: n\u2009=\u20094; CON: n\u2009=\u20094), twin (S: n\u2009=\u20095; CON: n\u2009=\u20095), or triplet (S: n\u2009=\u20095; CON: n\u2009=\u20095) pregnancies. Umbilical BF and fetal and placental measurements were obtained via Doppler ultrasonography every 10 d from days 50 to 110 of gestation. At parturition, lamb and placental weights were recorded, and cotyledonary tissue was collected. Data were analyzed for all pregnancies combined (ALL; singletons, twins, and triplets) and for multiple-bearing pregnancies (M; twins and triplets) using the MIXED procedure of SAS, with treatment, day of gestation, and their interaction included as fixed effects, and ewe included as a random effect. There was no treatment\u2009\u00d7\u2009day interaction for UBF in ALL or M (P\u2009=\u20090.51). However, a main effect of treatment was observed (P\u2009&amp;lt;\u20090.05), with UBF tending to be greater (P\u2009\u2264\u20090.10) on days 90 and 100 and greater (P\u2009=\u20090.03) on day 110, in S compared with CON ewes. Placentome size was not affected by treatment or treatment\u2009\u00d7\u2009day interactions in either analysis (P\u2009\u2265\u20090.37). There was no treatment\u2009\u00d7\u2009day interaction or main effect of treatment for fetal biparietal distance (BP) in ALL (P\u2009\u2265\u20090.11). In M pregnancies, BP was greater in fetuses from S ewes (main effect of treatment, P\u2009=\u20090.01), tending to be greater on day 60 (P\u2009=\u20090.07) and being greater on days 80, 90, and 110 (P\u2009\u2264\u20090.05). Fetal abdominal distance was not affected by treatment or treatment\u2009\u00d7\u2009day interactions in ALL or M (P\u2009\u2265\u20090.10). Lamb birth weight did not differ between treatments in ALL (P\u2009=\u20090.22); however, lambs born from S ewes tended to be heavier at birth in M pregnancies (P\u2009=\u20090.08) and tended to remain heavier at 60 d of age (P\u2009=\u20090.10). Using DESeq2, we identified 680 DEGs between the S and CON groups (P\u2009&amp;lt;\u20090.05 and |Log2FC| &amp;gt; 0.5). Among them, 566 genes were downregulated, and 114 were upregulated in the S group. These results demonstrate that shearing ewes on day 50 of gestation increases UBF and fetal skeletal growth, particularly in multiple-bearing pregnancies. The benefits of early-mid-gestation shearing appear most relevant when fetal demand is high, suggesting this management practice may improve lamb growth and performance in prolific ewe flocks.<\/jats:p>","DOI":"10.1093\/jas\/skag292","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:47:38Z","timestamp":1789040858000},"source":"Crossref","is-referenced-by-count":0,"title":["Shearing during early mid-gestation improves umbilical blood flow and fetal size in ewes carrying multiples"],"prefix":"10.1093","volume":"104","author":[{"given":"Mara A","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Veterinary & Biomedical Sciences, South Dakota State University , Brookings, SD 57007,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake R","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, South Dakota State University , Brookings, SD 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