{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:15Z","timestamp":1792785975809,"version":"4.5.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":259,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Centro para el Desarrollo Tecnol\u00f3gico Industrial, Ministry of Science and Innovation","award":["20220616"],"award-info":[{"award-number":["20220616"]}],"id":[{"id":"https:\/\/ror.org\/0124x7055","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nutritional strategies have been evaluated to alleviate the negative effects of weaning, including the incorporation of dietary fiber (DF). Dietary fiber comprises soluble and insoluble fractions, both important for intestinal health. This study evaluated the effects of three insoluble fiber (IF) sources\u2014coarse almond shells (AS), wheat bran (WB), and a commercial IF source (CIF)\u2014included in high-NDF diets (12.0%) for weaned piglets, compared with a lower-NDF control diet (NC; 10.2%). All diets were isoenergetic (net energy: 2,550\u2009kcal\/kg) and isonitrogenous (crude protein: 16.3%). Growth performance, dry matter digestibility, diarrhea incidence, jejunal gene expression, and jejunal and colonic microbiota composition were assessed 14\u2009d post-weaning. Neither growth performance nor digestibility was affected by treatment (P\u2009&amp;gt;\u20090.05). Piglets fed AS showed lower diarrhea incidence than NC-fed piglets (0.67 vs 1.67\u2009d; P\u2009&amp;lt;\u20090.05). Jejunal gene expression revealed higher expression of growth factors (EGF, IGF1) in AS-fed piglets than in WB-fed piglets (1.86 vs 0.63, 1.20 vs 0.86; P\u2009&amp;lt;\u20090.05). Dietary treatments also influenced intestinal microbiota composition (P\u2009&amp;lt;\u20090.05). In the jejunum, IF (WB, CIF, and AS) inclusion reduced the abundance of Proteobacteria compared with NC (0.31, 0.37, and 0.32 vs 7.23%; P\u2009&amp;lt;\u20090.05). At family level, WB increased Lactobacillaceae abundance relative to NC (89.24 vs 42.51%; P\u2009&amp;lt;\u20090.05), whereas CIF and AS showed intermediate values (59.67 and 57.88%). In the colon, microbial communities were affected by both IF inclusion and fiber physicochemical characteristics (P\u2009&amp;lt;\u20090.05). CIF-fed piglets exhibited higher Proteobacteria abundance (5.35%) and lower richness (P\u2009&amp;lt;\u20090.05), while AS (1.81%) produced microbial profiles similar to NC and WB (1.22 and 0.79%). Overall, ASs, characterized by their high IF content and coarse particle size, reduced diarrhea incidence, increased jejunal growth factor expression, and promoted a favorable intestinal microbial profile without affecting growth performance or digestibility. These findings support the use of ASs as a sustainable alternative fiber source in piglet nutrition.<\/jats:p>","DOI":"10.1093\/jas\/skag299","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:28:06Z","timestamp":1789651686000},"source":"Crossref","is-referenced-by-count":0,"title":["Almond shells as a sustainable alternative to commercial insoluble fiber sources in piglets: effects on performance and digestive health"],"prefix":"10.1093","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1915-4200","authenticated-orcid":false,"given":"Eduardo","family":"Ruiz","sequence":"first","affiliation":[{"name":"Department of Animal Production, Faculty of Veterinary Science, Regional Campus of International Excellence \u2018Mare Nostrum\u2019, University of Murcia , Espinardo, Murcia 30100,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Mart\u00ednez-Mir\u00f3","sequence":"additional","affiliation":[{"name":"Department of Animal Production, Faculty of Veterinary Science, Regional Campus of International Excellence \u2018Mare Nostrum\u2019, University of Murcia , Espinardo, Murcia 30100,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5169-321X","authenticated-orcid":false,"given":"Cristian Jes\u00fas","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Animal Production, Faculty of Veterinary Science, Regional Campus of International Excellence \u2018Mare Nostrum\u2019, University of Murcia , Espinardo, Murcia 30100,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3868-9961","authenticated-orcid":false,"given":"Luc\u00eda","family":"Ayala","sequence":"additional","affiliation":[{"name":"Department of Animal Production, Faculty of Veterinary Science, Regional Campus of International Excellence \u2018Mare Nostrum\u2019, University of Murcia , Espinardo, Murcia 30100,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Montalb\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Animal Production, Faculty of Veterinary Science, Regional Campus of International Excellence \u2018Mare Nostrum\u2019, University of Murcia , Espinardo, Murcia 30100,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefa","family":"Madrid","sequence":"additional","affiliation":[{"name":"Department of Animal Production, Faculty of Veterinary Science, Regional Campus of International Excellence \u2018Mare Nostrum\u2019, University of Murcia , Espinardo, Murcia 30100,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nieves","family":"Ortega","sequence":"additional","affiliation":[{"name":"Department of Animal Health, Faculty of Veterinary Science, Regional Campus of International Excellence \u2018Mare Nostrum\u2019, University of Murcia , Espinardo, Murcia 30100,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuensanta","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Animal Production, Faculty of Veterinary Science, Regional Campus of International Excellence \u2018Mare Nostrum\u2019, University of Murcia , Espinardo, Murcia 30100,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"2026101209464239700_skag299-B1","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/cr.2014.141","article-title":"EGF promotes mammalian cell growth by suppressing cellular senescence","volume":"25","author":"Alexander","year":"2015","journal-title":"Cell Res"},{"key":"2026101209464239700_skag299-B2","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1186\/s12859-015-0747-1","article-title":"SPINGO: a rapid species-classifier for microbial amplicon sequences","volume":"16","author":"Allard","year":"2015","journal-title":"BMC Bioinformatics"},{"key":"2026101209464239700_skag299-B3","author":"Andrews","year":"2010"},{"key":"2026101209464239700_skag299-B4","doi-asserted-by":"publisher","first-page":"234","DOI":"10.51227\/ojafr.2024.28","article-title":"Using lignocellulose fiber in feed to maintain health and improve the growth of post-wean piglets","volume":"14","author":"Ardana","year":"2024","journal-title":"OJAFR"},{"key":"2026101209464239700_skag299-B5","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.acthis.2013.07.005","article-title":"The role of epidermal growth factor in prevention of oxidative injury and apoptosis induced by intestinal ischemia\/reperfusion in rats","volume":"116","author":"Arda-Pirincci","year":"2014","journal-title":"Acta Histochem"},{"key":"2026101209464239700_skag299-B6","volume-title":"Official methods of analysis of AOAC international","author":"Association of Official Analytical Chemists (AOAC)","year":"2006","edition":"18th"},{"key":"2026101209464239700_skag299-B7","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.21105\/joss.03201","article-title":"microViz: an R package for microbiome data visualization and statistics","volume":"6","author":"Barnett","year":"2021","journal-title":"JOSS"},{"key":"2026101209464239700_skag299-B8","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/mog.0b013e32835004c6","article-title":"Insulin-like growth factor 1","volume":"28","author":"Bortvedt","year":"2012","journal-title":"Curr Opin Gastroenterol"},{"key":"2026101209464239700_skag299-B9","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: High-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat Methods"},{"key":"2026101209464239700_skag299-B10","doi-asserted-by":"publisher","first-page":"114335","DOI":"10.1016\/j.anifeedsci.2019.114335","article-title":"Effects of soluble and insoluble dietary fiber supplementation on growth performance, nutrient digestibility, intestinal microbe and barrier function in weaning piglet","volume":"260","author":"Chen","year":"2020","journal-title":"Anim Feed Sci Technol"},{"key":"2026101209464239700_skag299-B11","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.alcohol.2014.07.008","article-title":"Epidermal growth factor improved alcohol-induced inflammation in rats","volume":"48","author":"Chen","year":"2014","journal-title":"Alcohol"},{"key":"2026101209464239700_skag299-B12","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1203\/00006450-200012000-00016","article-title":"EGF regulates early embryonic mouse gut development in chemically defined organ culture","volume":"48","author":"Duh","year":"2000","journal-title":"Pediatr Res"},{"key":"2026101209464239700_skag299-B13","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1079\/ahr2005105","article-title":"Escherichia coli in postweaning diarrhea in pigs: an update on bacterial types, pathogenesis, and prevention strategies","volume":"6","author":"Fairbrother","year":"2005","journal-title":"Anim Health Res Rev"},{"key":"2026101209464239700_skag299-B14","author":"FAOSTAT","year":"2025"},{"key":"2026101209464239700_skag299-B15","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1515\/aoas-2016-0077","article-title":"Fiber substrates in the nutrition of weaned piglets\u2013a review","volume":"17","author":"Flis","year":"2017","journal-title":"Ann Anim Sci"},{"key":"2026101209464239700_skag299-B16","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/jcp.24687","article-title":"EGF regulates Claudin-2 and -4 expression through SRC and STAT3 in MDCK cells","volume":"230","author":"Garc\u00eda-Hern\u00e1ndez","year":"2015","journal-title":"J Cell Physiol"},{"key":"2026101209464239700_skag299-B17","doi-asserted-by":"publisher","first-page":"318","DOI":"10.2527\/jas.53770","article-title":"Insoluble nonstarch polysaccharides in diets for weaned piglets","volume":"90 Suppl 4","author":"Gerritsen","year":"2012","journal-title":"J Anim Sci"},{"key":"2026101209464239700_skag299-B18","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.3390\/ani10122368","article-title":"Porcine digestible peptides (PDP) in weanling diets regulates the expression of genes involved in gut barrier function, immune response and nutrient transport in nursery pigs","volume":"10","author":"Gonz\u00e1lez-Sol\u00e9","year":"2020","journal-title":"Animals (Basel)"},{"key":"2026101209464239700_skag299-B19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1017\/S1466252322000081","article-title":"Dietary fiber and its role in performance, welfare, and health of pigs","volume":"23","author":"Grze\u015bkowiak","year":"2022","journal-title":"Anim Health Res Rev"},{"key":"2026101209464239700_skag299-B20","doi-asserted-by":"publisher","first-page":"5903","DOI":"10.1007\/s00253-017-8304-7","article-title":"Evaluating the association between body weight and the intestinal microbiota of weaned piglets via 16S rRNA sequencing","volume":"101","author":"Han","year":"2017","journal-title":"Appl Microbiol Biotechnol"},{"key":"2026101209464239700_skag299-B21","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.aninu.2023.12.010","article-title":"Dietary nutrition, intestinal microbiota dysbiosis and post-weaning diarrhea in piglets","volume":"17","author":"Han","year":"2024","journal-title":"Anim Nutr"},{"key":"2026101209464239700_skag299-B22","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.2527\/2006.8461375x","article-title":"Intestinal morphology and enzymatic activity in newly weaned pigs fed contrasting fiber concentrations and fiber properties1","volume":"84","author":"Hedemann","year":"2006","journal-title":"J Anim Sci"},{"key":"2026101209464239700_skag299-B23","doi-asserted-by":"publisher","first-page":"4663","DOI":"10.1074\/jbc.272.8.4663","article-title":"Differential regulation of insulin-like Growth Factor-I (IGF-I) receptor gene expression by IGF-I and basic fibroblastic growth factor","volume":"272","author":"Hern\u00e1ndez-S\u00e1nchez","year":"1997","journal-title":"J Biol Chem"},{"key":"2026101209464239700_skag299-B24","doi-asserted-by":"publisher","first-page":"905489","DOI":"10.3389\/fbinf.2022.905489","article-title":"16S-ITGDB: An integrated database for improving species classification of prokaryotic 16S ribosomal RNA sequences","volume":"2","author":"Hsieh","year":"2022","journal-title":"Front Bioinformatics"},{"key":"2026101209464239700_skag299-B25","doi-asserted-by":"publisher","first-page":"28225","DOI":"10.1021\/acs.jafc.4c08816","article-title":"Plant-Derived polysaccharides benefit weaned piglets by regulating intestinal microbiota: a review","volume":"72","author":"Huang","year":"2024","journal-title":"J Agric Food Chem"},{"key":"2026101209464239700_skag299-B26","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1017\/s1751731115000919","article-title":"Review: Dietary fiber utilization and its effects on physiological functions and gut health of swine","volume":"9","author":"Jha","year":"2015","journal-title":"Animal"},{"key":"2026101209464239700_skag299-B27","doi-asserted-by":"publisher","first-page":"e20192195","DOI":"10.1084\/jem.20192195","article-title":"The role of IL-22 in intestinal health and disease","volume":"217","author":"Keir","year":"2020","journal-title":"J Exp Med"},{"key":"2026101209464239700_skag299-B28","doi-asserted-by":"publisher","first-page":"91","DOI":"10.11603\/ijmmr.2413-6077.2021.2.12516","article-title":"The effect of microcrystalline cellulose on the microflora of the colon","volume":"7","author":"Koval","year":"2022","journal-title":"IJMMR"},{"key":"2026101209464239700_skag299-B29","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1080\/1745039x.2015.1075671","article-title":"Fermented and extruded wheat bran in piglet diets: impact on performance, intestinal morphology, microbial metabolites in chyme and blood lipid radicals","volume":"69","author":"Kraler","year":"2015","journal-title":"Arch Anim Nutr"},{"key":"2026101209464239700_skag299-B30","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.ecl.2012.04.018","article-title":"Insulin-like growth factors in the gastrointestinal tract and liver","volume":"41","author":"Kuemmerle","year":"2012","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2026101209464239700_skag299-B31","doi-asserted-by":"publisher","first-page":"3390","DOI":"10.1128\/iai.01698-07","article-title":"Epidermal growth factor inhibits Campylobacter jejuni -induced claudin-4 disruption, loss of epithelial barrier function, and Escherichia coli translocation","volume":"76","author":"Lamb-Rosteski","year":"2008","journal-title":"Infect Immun"},{"key":"2026101209464239700_skag299-B32","doi-asserted-by":"publisher","first-page":"101175","DOI":"10.1016\/j.animal.2024.101175","article-title":"Particle size of insoluble fibres and gelation of soluble fibres influence digesta passage rate throughout the gastrointestinal tract of finishing pigs","volume":"18","author":"Lannuzel","year":"2024","journal-title":"Animal"},{"key":"2026101209464239700_skag299-B33","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.vetimm.2010.06.004","article-title":"Ultra-early weaning in piglets results in low serum IgA concentration and IL17 mRNA expression","volume":"137","author":"Levast","year":"2010","journal-title":"Vet Immunol Immunopathol"},{"key":"2026101209464239700_skag299-B34","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.3389\/fmicb.2020.01110","article-title":"Dietary soluble and insoluble fiber with or without enzymes altered the intestinal microbiota in weaned pigs challenged with enterotoxigenic E. coli F18","volume":"11","author":"Li","year":"2020","journal-title":"Front Microbiol"},{"key":"2026101209464239700_skag299-B35","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.3389\/fmicb.2018.02344","article-title":"Response of gut microbiota to dietary fiber and metabolic interaction with SCFAs in piglets","volume":"9","author":"Liu","year":"2018","journal-title":"Front Microbiol"},{"key":"2026101209464239700_skag299-B36","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1038\/s41559-018-0519-1","article-title":"Function and functional redundancy in microbial systems","volume":"2","author":"Louca","year":"2018","journal-title":"Nat Ecol Evol"},{"key":"2026101209464239700_skag299-B37","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1128\/aem.01996-06","article-title":"Quantitative and qualitative \u03b2 diversity measures lead to different insights into factors that structure microbial communities","volume":"73","author":"Lozupone","year":"2007","journal-title":"Appl Environ Microbiol"},{"key":"2026101209464239700_skag299-B38","doi-asserted-by":"publisher","first-page":"8228","DOI":"10.1128\/aem.71.12.8228-8235.2005","article-title":"UniFrac: a new phylogenetic method for comparing microbial communities","volume":"71","author":"Lozupone","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"2026101209464239700_skag299-B39","doi-asserted-by":"publisher","first-page":"114347","DOI":"10.1016\/j.anifeedsci.2019.114347","article-title":"Size reduction in feed technology and methods for determining, expressing and predicting particle size: a review","volume":"261","author":"Lyu","year":"2020","journal-title":"Anim Feed Sci Technol"},{"key":"2026101209464239700_skag299-B40","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1016\/j.jece.2017.05.037","article-title":"Novel biosorbents from almond shells: Characterization and adsorption properties modeling for Cu(II) ions from aqueous solutions","volume":"5","author":"Maaloul","year":"2017","journal-title":"J Environ Chem Eng"},{"key":"2026101209464239700_skag299-B41","doi-asserted-by":"publisher","first-page":"e0374422","DOI":"10.1128\/spectrum.03744-22","article-title":"Impact of intestinal microbiota on growth performance of suckling and weaned piglets","volume":"11","author":"Mahmud","year":"2023","journal-title":"Microbiol Spectr"},{"key":"2026101209464239700_skag299-B43","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1079\/asc20053","article-title":"Inclusion of oat hulls in diets for young pigs based on cooked maize or cooked rice","volume":"82","author":"Mateos","year":"2006","journal-title":"Anim Sci"},{"key":"2026101209464239700_skag299-B44","doi-asserted-by":"publisher","first-page":"e61217","DOI":"10.1371\/journal.pone.0061217","article-title":"phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data","volume":"8","author":"McMurdie","year":"2013","journal-title":"PLoS One"},{"key":"2026101209464239700_skag299-B45","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.jand.2016.09.021","article-title":"Understanding the physics of functional fibers in the gastrointestinal tract: an evidence-based approach to resolving enduring misconceptions about insoluble and soluble fiber","volume":"117","author":"McRorie","year":"2017","journal-title":"J Acad Nutr Diet"},{"key":"2026101209464239700_skag299-B46","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13068-015-0207-1","article-title":"Characterization of cell wall components of wheat bran following hydrothermal pretreatment and fractionation","volume":"8","author":"Merali","year":"2015","journal-title":"Biotechnol Biofuels"},{"key":"2026101209464239700_skag299-B47","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1017\/s0007114511005216","article-title":"Coarse, but not finely ground, dietary fibre increases intestinalFirmicutes: Bacteroidetesratio and reduces diarrhoea induced by experimental infection in piglets","volume":"108","author":"Molist","year":"2012","journal-title":"Br J Nutr"},{"key":"2026101209464239700_skag299-B48","first-page":"189","volume-title":"Normas FEDNA de alimentaci\u00f3n de ganado porcino","author":"Molist","year":"2023","edition":"3rd"},{"key":"2026101209464239700_skag299-B49","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.2527\/jas.2011-4160","article-title":"Comparative effects of level of dietary fiber and sanitary conditions on the growth and health of weanling pigs","volume":"90","author":"Montagne","year":"2012","journal-title":"J Anim Sci"},{"key":"2026101209464239700_skag299-B50","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s40168-018-0521-5","article-title":"IDTAXA: a novel approach for accurate taxonomic classification of microbiome sequences","volume":"6","author":"Murali","year":"2018","journal-title":"Microbiome"},{"key":"2026101209464239700_skag299-B0312590","author":"Oksanen","year":"2019"},{"key":"2026101209464239700_skag299-B51","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1590\/s1516-35982012000300024","article-title":"Fiber sources in diets for newly weaned piglets","volume":"41","author":"Pascoal","year":"2012","journal-title":"R Bras Zootec"},{"key":"2026101209464239700_skag299-B52","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.prevetmed.2010.11.014","article-title":"Observations of variable inter-observer agreement for clinical evaluation of faecal consistency in grow-finishing pigs","volume":"98","author":"Pedersen","year":"2011","journal-title":"Prev Vet Med"},{"key":"2026101209464239700_skag299-B53","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13028-017-0299-7","article-title":"Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies","volume":"59","author":"Rhouma","year":"2017","journal-title":"Acta Vet Scand"},{"key":"2026101209464239700_skag299-B54","doi-asserted-by":"publisher","first-page":"skaf420","DOI":"10.1093\/jas\/skaf420","article-title":"Reducing the weaning impact in piglets with dietary fiber: the role of milled almond shells compared to wheat bran","volume":"104104","author":"Ruiz","year":"2026","journal-title":"J Anim Sci"},{"key":"2026101209464239700_skag299-B55","doi-asserted-by":"publisher","first-page":"383","DOI":"10.22358\/jafs\/67718\/2003","article-title":"Acid-insoluble ash as a marker in digestibility studies: a review","volume":"12","author":"Sales","year":"2003","journal-title":"J Anim Feed Sci"},{"key":"2026101209464239700_skag299-B56","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/1745039x.2019.1704174","article-title":"Effects of soybean hulls and lignocellulose on performance, nutrient digestibility, microbial metabolites and immune response in piglets","volume":"74","author":"Slama","year":"2020","journal-title":"Arch Anim Nutr"},{"key":"2026101209464239700_skag299-B57","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/mSystems.01374-20","article-title":"Dietary fiber ameliorates lipopolysaccharide-induced intestinal barrier function damage in piglets by modulation of intestinal microbiome","volume":"6","author":"Sun","year":"2021","journal-title":"mSystems"},{"key":"2026101209464239700_skag299-B58","doi-asserted-by":"publisher","first-page":"16655","DOI":"10.1038\/s41598-018-34912-8","article-title":"Divergent short-chain fatty acid production and succession of colonic microbiota arise in fermentation of variously-sized wheat bran fractions","volume":"8","author":"Tuncil","year":"2018","journal-title":"Sci Reports"},{"key":"2026101209464239700_skag299-B59","doi-asserted-by":"publisher","first-page":"6194","DOI":"10.1038\/s41598-023-33291-z","article-title":"Dietary micro-fibrillated cellulose improves growth, reduces diarrhea, modulates gut microbiota, and increases butyrate production in post-weaning piglets","volume":"13","author":"Uddin","year":"2023","journal-title":"Sci Rep"},{"key":"2026101209464239700_skag299-B60","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.3390\/ani11082418","article-title":"The impact of weaning stress on gut health and the mechanistic aspects of several feed additives contributing to improved gut health function in Weanling Piglets\u2014A review","volume":"11","author":"Upadhaya","year":"2021","journal-title":"Animals"},{"key":"2026101209464239700_skag299-B61","doi-asserted-by":"publisher","first-page":"3583","DOI":"10.3168\/jds.S0022-0302(91)78551-2","article-title":"Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition","volume":"74","author":"Van Soest","year":"1991","journal-title":"J Dairy Sci"},{"key":"2026101209464239700_skag299-B63","doi-asserted-by":"crossref","first-page":"352","DOI":"10.32614\/RJ-2016-025","article-title":"Using DECIPHER v2. 0 to analyze big biological sequence data in R","volume":"8","author":"Wright","year":"2016","journal-title":"R J"},{"key":"2026101209464239700_skag299-B64","doi-asserted-by":"crossref","first-page":"236","DOI":"10.5713\/ajas.16.0077","article-title":"Effects of alanyl-glutamine supplementation on the small intestinal mucosa barrier in weaned piglets","volume":"30","author":"Xing","year":"2017","journal-title":"Asian-Australas J Anim Sci"},{"key":"2026101209464239700_skag299-B65","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1080\/1745039x.2016.1183364","article-title":"Effect of high fibre diets formulated with different fibrous ingredients on performance, nutrient digestibility and faecal microbiota of weaned piglets","volume":"70","author":"Yu","year":"2016","journal-title":"Arch Anim Nutr"},{"key":"2026101209464239700_skag299-B66","doi-asserted-by":"publisher","first-page":"E638","DOI":"10.1152\/ajpendo.00022.2018","article-title":"Intestinal epithelial cell-specific IGF1 promotes the expansion of intestinal stem cells during epithelial regeneration and functions on the intestinal immune homeostasis","volume":"315","author":"Zheng","year":"2018","journal-title":"Am J Physiol Endocrinol Metab"}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jas\/advance-article-pdf\/doi\/10.1093\/jas\/skag299\/71189039\/skag299.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/doi\/10.1093\/jas\/skag299\/71189039\/skag299.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/doi\/10.1093\/jas\/skag299\/71189039\/skag299.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:46:52Z","timestamp":1791812812000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/doi\/10.1093\/jas\/skag299\/8812279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":65,"URL":"https:\/\/doi.org\/10.1093\/jas\/skag299","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"skag299"}}