{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T10:51:53Z","timestamp":1768906313085,"version":"3.49.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nationalarchives.gov.uk\/doc\/open-government-licence\/version\/3\/"}],"funder":[{"DOI":"10.13039\/501100000040","name":"Agriculture and Agri-Food Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005019","name":"Beef Cattle Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,7]]},"DOI":"10.1093\/jas\/sky245","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T20:21:47Z","timestamp":1529353307000},"page":"3606-3621","source":"Crossref","is-referenced-by-count":18,"title":["Effect of subcutaneous meloxicam on indicators of acute pain and distress after castration and branding in 2-mo-old beef calves1,2"],"prefix":"10.1093","volume":"96","author":[{"given":"Daniela M","family":"Mel\u00e9ndez","sequence":"first","affiliation":[{"name":"Department of Production Animal Health, University of Calgary, Calgary, Canada"},{"name":"Agriculture and Agri-Food Canada, Lethbridge Research and Development Centre, Lethbridge, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Marti","sequence":"additional","affiliation":[{"name":"Department of Production Animal Health, University of Calgary, Calgary, Canada"},{"name":"IRTA Department of Ruminant Production, Caldes de Montbui, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ed A","family":"Pajor","sequence":"additional","affiliation":[{"name":"Department of Production Animal Health, University of Calgary, Calgary, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0969-6740","authenticated-orcid":false,"given":"Diego","family":"Moya","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences, University of Saskatchewan, Saskatoon, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9sir\u00e9e","family":"Gellatly","sequence":"additional","affiliation":[{"name":"Department of Production Animal Health, University of Calgary, Calgary, Canada"},{"name":"Agriculture and Agri-Food Canada, Lethbridge Research and Development Centre, Lethbridge, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene D","family":"Janzen","sequence":"additional","affiliation":[{"name":"Department of Production Animal Health, University of Calgary, Calgary, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen S","family":"Schwartzkopf-Genswein","sequence":"additional","affiliation":[{"name":"Agriculture and Agri-Food Canada, Lethbridge Research and Development Centre, Lethbridge, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,6,15]]},"reference":[{"key":"key\n\t\t\t\t20180907053327_CIT0001","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.vetimm.2012.11.018","article-title":"Administration of anesthetic and analgesic prevent the suppression of many leukocyte responses following surgical castration and physical dehorning","volume":"151","author":"Ballou","year":"2013","journal-title":"Vet. Immunol. Immunopathol"},{"key":"key\n\t\t\t\t20180907053327_CIT0002","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.livprodsci.2005.04.006","article-title":"Effects of age and method of castration on performance and stress response of beef male cattle: A review","volume":"97","author":"Bretschneider","year":"2005","journal-title":"Livest. Prod. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0003","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.2527\/jas.2014-8695","article-title":"Effect of castration timing and oral meloxicam administration on growth performance, inflammation, behavior, and carcass quality of beef calves","volume":"93","author":"Brown","year":"2015","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0004","author":"Canada Council of Animal Care (CCAC)","year":"2009"},{"key":"key\n\t\t\t\t20180907053327_CIT0005","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1016\/j.jprot.2012.04.004","article-title":"Acute phase proteins in ruminants","volume":"75","author":"Ceciliani","year":"2012","journal-title":"J. Proteomics"},{"key":"key\n\t\t\t\t20180907053327_CIT0006","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/1746-6148-8-153","article-title":"Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves following scoop dehorning without local anesthesia","volume":"8","author":"Coetzee","year":"2012","journal-title":"BMC Vet. Res"},{"key":"key\n\t\t\t\t20180907053327_CIT0007","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1746-6148-6-12","article-title":"A survey of castration methods and associated livestock management practices performed by bovine veterinarians in the United States","volume":"6","author":"Coetzee","year":"2010","journal-title":"BMC Vet. Res"},{"key":"key\n\t\t\t\t20180907053327_CIT0008","first-page":"375","article-title":"The behavioral assessment and alleviation of pain associated with castration in beef calves treated with flunixin meglumine and caudal lidocaine epidural anesthesia with epinephrine","volume":"50","author":"Currah","year":"2009","journal-title":"Can. Vet. J"},{"key":"key\n\t\t\t\t20180907053327_CIT0009","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1080\/00480169.1999.36143","article-title":"The behaviour pattern of lambs after castration using a rubber ring and\/or castrating clamp with or without local anaesthetic","volume":"47","author":"Dinniss","year":"1999","journal-title":"N. Z. Vet. J"},{"key":"key\n\t\t\t\t20180907053327_CIT0010","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.2527\/2002.8041044x","article-title":"Effects of ketoprofen alone or in combination with local anesthesia during the castration of bull calves on plasma cortisol, immunological, and inflammatory responses","volume":"80","author":"Earley","year":"2002","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0011","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1751-0813.1986.tb02864.x","article-title":"Stress in calves castrated surgically or by the application of rubber rings","volume":"63","author":"Fell","year":"1986","journal-title":"Aust. Vet. J"},{"key":"key\n\t\t\t\t20180907053327_CIT0012","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1139\/y91-093","article-title":"Central mechanisms of visceral pain","volume":"69","author":"Gebhart","year":"1991","journal-title":"Can. J. Physiol. Pharmacol"},{"key":"key\n\t\t\t\t20180907053327_CIT0013","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.3168\/jds.2009-2813","article-title":"The effect of meloxicam on behavior and pain sensitivity of dairy calves following cautery dehorning with a local anesthetic","volume":"93","author":"Heinrich","year":"2010","journal-title":"J. Dairy Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0014","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3168\/jds.2008-1424","article-title":"The impact of meloxicam on postsurgical stress associated with cautery dehorning","volume":"92","author":"Heinrich","year":"2009","journal-title":"J. Dairy Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0015","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13028-014-0061-3","article-title":"Time lag between peak concentrations of plasma and salivary cortisol following a stressful procedure in dairy cattle","volume":"56","author":"Hernandez","year":"2014","journal-title":"Acta Vet. Scand"},{"key":"key\n\t\t\t\t20180907053327_CIT0016","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2527\/jas1977.454699x","article-title":"Bulls steers. II. Palatability and retail acceptance","volume":"45","author":"Jacobs","year":"1977","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0017","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2885.2004.00617.x","article-title":"Pharmacodynamics and pharmacokinetics of nonsteroidal anti-inflammatory drugs in species of veterinary interest","volume":"27","author":"Lees","year":"2004","journal-title":"J. Vet. Pharmacol. Ther"},{"key":"key\n\t\t\t\t20180907053327_CIT0018","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1017\/S0022029901004721","article-title":"Effect of suckling on the release of oxytocin, prolactin, cortisol, gastrin, cholecystokinin, somatostatin and insulin in dairy cows and their calves","volume":"68","author":"Lupoli","year":"2001","journal-title":"J. Dairy Res"},{"key":"key\n\t\t\t\t20180907053327_CIT0019","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1017\/CBO9780511810893.006","article-title":"Recording methods","volume-title":"Measuring behaviour: An introductory guide","author":"Martin","year":"2007","edition":"3rd ed"},{"key":"key\n\t\t\t\t20180907053327_CIT0020","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.2527\/jas2017.1978","article-title":"Effect of timing of subcutaneous meloxicam administration on indicators of pain after knife castration of weaned calves","volume":"95","author":"Mel\u00e9ndez","year":"2017","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0021","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.2527\/jas2017.1762","article-title":"Effect of band and knife castration of beef calves on welfare indicators of pain at three relevant industry ages: I. Acute pain","volume":"95","author":"Mel\u00e9ndez","year":"2017","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0022","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0885-3924(98)00141-9","article-title":"Analgesic effects of nonsteroidal anti-inflammatory drugs in cancer pain due to somatic or visceral mechanisms","volume":"17","author":"Mercadante","year":"1999","journal-title":"J. Pain Symptom Manage"},{"key":"key\n\t\t\t\t20180907053327_CIT0023","first-page":"958","article-title":"Management practices associated with pain in cattle on western Canadian cow\u2013calf operations: A mixed methods study","volume":"95","author":"Moggy","year":"2017","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0024","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.2527\/jas.2012-6007","article-title":"Comparative effects of castration and dehorning in series or concurrent castration and dehorning procedures on stress responses and production in Holstein calves","volume":"91","author":"Mosher","year":"2013","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0025","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.2527\/jas.2013-7298","article-title":"Effects of castration method and frequency of intramuscular injections of ketoprofen on behavioral and physiological indicators of pain in beef cattle","volume":"92","author":"Moya","year":"2014","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0026","first-page":"442","article-title":"An investigation of the effects of ketoprofen following rumen fistulation surgery in lactating dairy cows","volume":"55","author":"Newby","year":"2014","journal-title":"Can. Vet. J"},{"key":"key\n\t\t\t\t20180907053327_CIT0027","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2527\/2006.842351x","article-title":"Effect of carprofen administration during banding or burdizzo castration of bulls on plasma cortisol, in vitro interferon-gamma production, acute-phase proteins, feed intake, and growth","volume":"84","author":"Pang","year":"2006","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0028","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0007-1935(89)90034-1","article-title":"Salivary cortisol in pigs following adrenocorticotrophic hormone stimulation: Comparison with plasma levels","volume":"145","author":"Parrott","year":"1989","journal-title":"Br. Vet. J"},{"key":"key\n\t\t\t\t20180907053327_CIT0029","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1051\/vetres:2004002","article-title":"Application of acute phase protein measurements in veterinary clinical chemistry","volume":"35","author":"Petersen","year":"2004","journal-title":"Vet. Res"},{"key":"key\n\t\t\t\t20180907053327_CIT0030","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.2527\/jas.2012-6070","article-title":"Impact of oral meloxicam administration before and after band castration on feedlot performance and behavioral response in weanling beef bulls","volume":"91","author":"Repenning","year":"2013","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0031","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.2527\/jas.2015-9160","article-title":"Effect of surgical castration with or without oral meloxicam on the acute inflammatory response in yearling beef bulls","volume":"93","author":"Roberts","year":"2015","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0032","volume-title":"Code of practice for the care and handling of beef cattle: Review of scientific research on priority issues","author":"Schwartzkopf-Genswein","year":"2012"},{"key":"key\n\t\t\t\t20180907053327_CIT0033","doi-asserted-by":"crossref","first-page":"369","DOI":"10.4141\/A96-127","article-title":"Comparison of hot-iron and freeze branding on cortisol levels and pain sensitivity in beef cattle","volume":"77","author":"Schwartzkopf-Genswein","year":"1997","journal-title":"Can. J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0034","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.2527\/1997.7582064x","article-title":"Behavior of cattle during hot-iron and freeze branding and the effects on subsequent handling ease","volume":"75","author":"Schwartzkopf-Genswein","year":"1997","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0035","first-page":"265","volume-title":"Large animal internal medicine","author":"Smith","year":"2008","edition":"4th ed"},{"key":"key\n\t\t\t\t20180907053327_CIT0036","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/00480169.2005.36560","article-title":"The welfare significance of the castration of cattle: A review","volume":"53","author":"Stafford","year":"2005","journal-title":"N. Z. Vet. J"},{"key":"key\n\t\t\t\t20180907053327_CIT0037","doi-asserted-by":"crossref","first-page":"935","DOI":"10.2527\/jas.2012-5190","article-title":"Effect of castration and dehorning singularly or combined on the behavior and physiology of Holstein calves","volume":"91","author":"Sutherland","year":"2013","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0038","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1746-6148-8-48","article-title":"Assessment of behavioral changes associated with oral meloxicam administration at time of dehorning in calves using a remote triangulation device and accelerometers","volume":"8","author":"Theurer","year":"2012","journal-title":"BMC Vet. Res"},{"key":"key\n\t\t\t\t20180907053327_CIT0039","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2527\/2003.8151281x","article-title":"Effect of ketoprofen, lidocaine local anesthesia, and combined xylazine and lidocaine caudal epidural anesthesia during castration of beef cattle on stress responses, immunity, growth, and behavior","volume":"81","author":"Ting","year":"2003","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0040","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.2527\/jas.2014-7887","article-title":"Pain sensitivity and healing of hot-iron cattle brands","volume":"92","author":"Tucker","year":"2014","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0041","first-page":"1","volume-title":"UBC Animal Welfare Program: SOP-HOBO data loggers","author":"University of British Columbia Animal Welfare Program (UBC AWP)","year":"2013"},{"key":"key\n\t\t\t\t20180907053327_CIT0042","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1203\/00006450-199803000-00006","article-title":"Postnatal oxytocin injections cause sustained weight gain and increased nociceptive thresholds in male and female rats","volume":"43","author":"Uvn\u00e4s-Moberg","year":"1998","journal-title":"Pediatr. Res"},{"key":"key\n\t\t\t\t20180907053327_CIT0043","doi-asserted-by":"crossref","first-page":"498","DOI":"10.2527\/jas.2013-6857","article-title":"Impact of oral meloxicam on circulating physiological biomarkers of stress and inflammation in beef steers after long-distance transportation","volume":"92","author":"Van Engen","year":"2014","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t20180907053327_CIT0044","first-page":"191","article-title":"Castration","volume-title":"Bovine surgery and lameness","author":"Weaver","year":"2008","edition":"2nd ed"}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jas\/article-pdf\/96\/9\/3606\/25694106\/sky245.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T12:34:08Z","timestamp":1571488448000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/96\/9\/3606\/5038397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,15]]},"references-count":44,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,6,15]]},"published-print":{"date-parts":[[2018,9,7]]}},"URL":"https:\/\/doi.org\/10.1093\/jas\/sky245","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,9]]},"published":{"date-parts":[[2018,6,15]]}}}