{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:10:03Z","timestamp":1791198603289,"version":"4.1.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2016YFD0501201"],"award-info":[{"award-number":["2016YFD0501201"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key Programs of frontier scientific research of the Chinese Academy of Sciences","award":["QYZDY-SSW-SMC008"],"award-info":[{"award-number":["QYZDY-SSW-SMC008"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31330075"],"award-info":[{"award-number":["31330075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2017JJ1020"],"award-info":[{"award-number":["2017JJ1020"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100014215","name":"Huxiang Youth talent Support Program","doi-asserted-by":"crossref","award":["2016RS3028"],"award-info":[{"award-number":["2016RS3028"]}],"id":[{"id":"10.13039\/501100014215","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Young Elite Scientists Sponsorship Program by CAST","award":["YESS20160086"],"award-info":[{"award-number":["YESS20160086"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1093\/jas\/sky388","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T18:21:51Z","timestamp":1539195711000},"page":"353-358","source":"Crossref","is-referenced-by-count":42,"title":["Rapid Communication: The relationship of enterocyte proliferation with intestinal morphology and nutrient digestibility in weaning piglets"],"prefix":"10.1093","volume":"97","author":[{"given":"Lixia","family":"Wang","sequence":"first","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China"},{"name":"Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Ag"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanling","family":"Yan","sequence":"additional","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China"},{"name":"Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Ag"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Ding","sequence":"additional","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Yin","sequence":"additional","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Xiong","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Ag"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Yin","sequence":"additional","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China"},{"name":"Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Ag"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huansheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China"},{"name":"Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Ag"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"key\n\t\t\t\t2019010906375755700_CIT0001","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/1745039X.2016.1206735","article-title":"Effect of hydrolysable tannins on intestinal morphology, proliferation and apoptosis in entire male pigs","volume":"70","author":"Bili\u0107-\u0160obot","year":"2016","journal-title":"Arch. Anim. Nutr"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0002","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2049-1891-4-19","article-title":"The biological stress of early weaned piglets","volume":"4","author":"Campbell","year":"2013","journal-title":"J. Anim. Sci. Biotechnol"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0003","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3945\/ajcn.2008.27073","article-title":"Generation of epidermal growth factor-expressing Lactococcus lactis and its enhancement on intestinal development and growth of early-weaned mice","volume":"89","author":"Cheung","year":"2009","journal-title":"Am. J. Clin. Nutr"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0004","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1128\/IAI.05820-11","article-title":"Enhanced wound healing by recombinant Escherichia coli Nissle 1917 via human epidermal growth factor receptor in human intestinal epithelial cells: therapeutic implication using recombinant probiotics","volume":"80","author":"Choi","year":"2012","journal-title":"Infect. Immun"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0005","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.2527\/jas.2009-2511","article-title":"Gastrointestinal tract mucosal histomorphometry and epithelial cell proliferation and apoptosis in neonatal and adult dogs","volume":"88","author":"De Conto","year":"2010","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0006","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1042\/cs0740301","article-title":"Epithelial cell proliferation and intestinal absorptive function during starvation and refeeding in the rat","volume":"74","author":"Goodlad","year":"1988","journal-title":"Clin. Sci"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0007","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3390\/toxins5020396","article-title":"Modulation of intestinal functions following mycotoxin ingestion: meta-analysis of published experiments in animals","volume":"5","author":"Grenier","year":"2013","journal-title":"Toxins"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0008","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.2527\/jas.2012-5864","article-title":"Comparison of ileal and total tract nutrient digestibility of dry dog foods","volume":"91","author":"Hendriks","year":"2013","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0009","first-page":"4005","article-title":"Effect of combined xylanase and phytase on growth performance, apparent total tract digestibility, and carcass characteristics in growing pigs fed corn-based diets containing high-fiber coproducts","volume":"95","author":"Jang","year":"2017","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0010","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/iep.12129","article-title":"Influence of dietary supplementation with flaxseed and lactobacilli on the mucosal morphology and proliferative cell rate in the jejunal mucosa of piglets after weaning","volume":"96","author":"Jonecova","year":"2015","journal-title":"Int. J. Exp. Pathol"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0011","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.tvjl.2007.04.018","article-title":"Effects of epidermal growth factor on atrophic enteritis in piglets induced by experimental porcine epidemic diarrhoea virus","volume":"177","author":"Jung","year":"2008","journal-title":"Vet. J"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0012","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1210\/en.2014-1112","article-title":"Impact of diet-induced obesity on intestinal stem cells: hyperproliferation but impaired intrinsic function that requires insulin\/IGF1","volume":"155","author":"Mah","year":"2014","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0013","doi-asserted-by":"crossref","first-page":"G413","DOI":"10.1152\/ajpgi.00304.2006","article-title":"Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs","volume":"293","author":"Moeser","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0014","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1017\/S000711450720580X","article-title":"Main intestinal markers associated with the changes in gut architecture and function in piglets after weaning","volume":"97","author":"Montagne","year":"2007","journal-title":"Br. J. Nutr"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/nmo.13118","article-title":"Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity","volume":"29","author":"Pohl","year":"2017","journal-title":"Neurogastroenterol. Motil"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0016","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.2527\/jas.2014-8230","article-title":"Oral administration of putrescine and proline during the suckling period improves epithelial restitution after early weaning in piglets","volume":"93","author":"Wang","year":"2015","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0017","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40104-016-0063-2","article-title":"Developmental changes in intercellular junctions and Kv channels in the intestine of piglets during the suckling and post-weaning periods","volume":"7","author":"Wang","year":"2016","journal-title":"J. Anim. Sci. Biotechnol"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0018","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/jam.12833","article-title":"Oral administration of Lactococcus lactis-expressed recombinant porcine epidermal growth factor stimulates the development and promotes the health of small intestines in early-weaned piglets","volume":"119","author":"Xu","year":"2015","journal-title":"J. Appl. Microbiol"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0019","doi-asserted-by":"crossref","first-page":"36939","DOI":"10.1038\/srep36939","article-title":"Effects of weaning on intestinal crypt epithelial cells in piglets","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0020","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/1745039X.2016.1183365","article-title":"Effects of dietary addition of heat-killed Mycobacterium phlei on growth performance, immune status and anti-oxidative capacity in early weaned piglets","volume":"70","author":"Zhong","year":"2016","journal-title":"Arch. Anim. Nutr"},{"key":"key\n\t\t\t\t2019010906375755700_CIT0021","first-page":"1049","article-title":"Maternal diabetes affects cell proliferation in developing rat placenta","volume":"26","author":"Zorn","year":"2011","journal-title":"Histol. Histopathol"}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jas\/article-pdf\/97\/1\/353\/27452315\/sky388.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T06:41:36Z","timestamp":1589956896000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/97\/1\/353\/5125948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,10]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,10,10]]},"published-print":{"date-parts":[[2019,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jas\/sky388","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1]]},"published":{"date-parts":[[2018,10,10]]}}}