{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:17:25Z","timestamp":1779333445782,"version":"3.51.4"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1093\/jas\/sky423","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T03:06:05Z","timestamp":1542078365000},"page":"184-191","source":"Crossref","is-referenced-by-count":11,"title":["Effects of repeated arthrocentesis on systemic cytokine expression and leukocyte population in young horses challenged with intra-articular lipopolysaccharide"],"prefix":"10.1093","volume":"97","author":[{"given":"Carrie L","family":"Hunt","sequence":"first","affiliation":[{"name":"Department of Animal Science, Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica Lucia","family":"Leatherwood","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University, College Station, TX"},{"name":"Department of Animal Science, Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josie Ann","family":"Coverdale","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis L","family":"Sigler","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha M","family":"Vogelsang","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn E","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"key":"key\n\t\t\t\t2019010906483270100_CIT0001","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s12917-017-1089-1","article-title":"Changes in concentrations of haemostatic and inflammatory biomarkers in synovial fluid after intra-articular injection of lipopolysaccharide in horses","volume":"13","author":"Andreassen","year":"2017","journal-title":"BMC Vet. Res"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0002","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1053\/jvet.2001.28430","article-title":"Synovial fluid cytokines and eicosanoids as markers of joint disease in horses","volume":"30","author":"Bertone","year":"2001","journal-title":"Vet. Surg"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0003","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1016\/j.joca.2016.01.960","article-title":"Sustained intra-articular release of celecoxib from in situ forming hydrogels made of acetyl-capped PCLA-PEG-PCLA triblock copolymers in an equine model of osteoarthritis","volume":"24","author":"Cokelaere","year":"2016","journal-title":"Osteoarthr. Cartil"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0004","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.jevs.2015.07.023","article-title":"Synovial fluid and serum concentrations of interleukin-1 receptor antagonist and Interleukin-1\u03b2 in naturally occurring equine osteoarthritis and septic arthritis","volume":"35","author":"Ehrle","year":"2015","journal-title":"J. Eq. Vet. Sci"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0005","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1532-950X.1994.tb00497.x","article-title":"Effect of betamethasone and exercise on equine carpal joints with osteochondral fragments","volume":"23","author":"Foland","year":"1994","journal-title":"Vet. Surg"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0006","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.tvjl.2004.07.008","article-title":"Medical treatment of osteoarthritis in the horse - a review","volume":"171","author":"Goodrich","year":"2006","journal-title":"Vet. J"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0007","doi-asserted-by":"crossref","first-page":"R35","DOI":"10.1186\/ar2640","article-title":"Inflammatory mediators and cartilage biomarkers in synovial fluid after a single inflammatory insult: a longitudinal experimental study","volume":"11","author":"de Grauw","year":"2009","journal-title":"Arthritis Res. Ther"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0008","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2460\/ajvr.1993.54.03.379","article-title":"Effects of intra-articularly administered endotoxin on clinical signs of disease and synovial fluid tumor necrosis factor, interleukin 6, and prostaglandin E2 values in horses","volume":"54","author":"Hawkins","year":"1993","journal-title":"Am. J. Vet. Res"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0009","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.2042-3306.1988.tb04643.x","article-title":"Use of autogenous cartilage particles to create a model of naturally occurring degenerative joint disease in the horse","volume":"20","author":"Hurtig","year":"1988","journal-title":"Equine Vet. J"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0010","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.2042-3306.2010.00140.x","article-title":"Cytokine and catabolic enzyme expression in synovium, synovial fluid and articular cartilage of naturally osteoarthritic equine carpi","volume":"42","author":"Kamm","year":"2010","journal-title":"Equine Vet. J"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0011","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF00197186","article-title":"The role of cytokines in the pathogenesis of rheumatoid arthritis","volume":"11","author":"Lipsky","year":"1989","journal-title":"Springer Semin. Immunopathol"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0013","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0014","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.2527\/jas.2012-5981","article-title":"Influence of an intra-articular lipopolysaccharide challenge on markers of inflammation and cartilage metabolism in young horses","volume":"91","author":"Lucia","year":"2013","journal-title":"J. Anim. Sci"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2460\/ajvr.1979.40.01.11","article-title":"Experimentally induced arthritis of the equine carpus: clinical determinations","volume":"40","author":"McIlwraith","year":"1979","journal-title":"Am. J. Vet. Res"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0016","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2105-3-17","article-title":"The limit fold change model: a practical approach for selecting differentially expressed genes from microarray data","volume":"3","author":"Mutch","year":"2002","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0017","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2746\/042516409X464780","article-title":"Effect of lipopolysaccharide infusion on gene expression of inflammatory cytokines in normal horses in vivo","volume":"41","author":"Nieto","year":"2009","journal-title":"Equine Vet. J"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0018","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.2042-3306.1994.tb04056.x","article-title":"Experimentally-induced synovitis as a model for acute synovitis in the horse","volume":"26","author":"Palmer","year":"1994","journal-title":"Equine Vet. J"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0019","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.2460\/ajvr.1996.57.07.1080","article-title":"Immunohistochemical analysis of an equine model of synovitis-induced arthritis","volume":"57","author":"Todhunter","year":"1996","journal-title":"Am. J. Vet. Res"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0021","first-page":"224","article-title":"Effects of intramuscular polysulfated glycosaminoglycan on chemical and physical defects in equine articular cartilage","volume":"53","author":"Trotter","year":"1989","journal-title":"Can. J. Vet. Res"},{"key":"key\n\t\t\t\t2019010906483270100_CIT0022","first-page":"25","article-title":"Changes in equine carpal joint synovial fluid in response to the injection of two local anesthetic agents","volume":"79","author":"White","year":"1989","journal-title":"Cornell Vet"}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jas\/article-pdf\/97\/1\/184\/27452463\/sky423.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:34:31Z","timestamp":1775266471000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/97\/1\/184\/5180077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,13]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,11,13]]},"published-print":{"date-parts":[[2019,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jas\/sky423","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1]]},"published":{"date-parts":[[2018,11,13]]}}}