{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:30:19Z","timestamp":1770222619430,"version":"3.49.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Assisted calves are often born weak, injured, or oxygen deprived and have a higher risk of morbidity and mortality. The objective was to investigate the impact of using pain mitigation at birth in assisted beef calves on physiological indicators of pain and inflammation, passive immunity, health, and growth. Thirty-three primiparous cows and their calves requiring assistance at birth on two ranches located in southern Alberta were enrolled. Data collected at birth include date and time of calving, calf sex, meconium staining, presentation of calf, and calving difficulty (easy assist: one person manually delivered the calf; difficult assist: delivery by two or more people, or mechanical assistance). Within 10 min of birth, calves were stratified by calving difficulty, randomized to a medication group, and received a subcutaneous dose of meloxicam (0.5 mg\/kg BW) or an equivalent volume of placebo. Cow\u2013calf pairs were then placed in individual box stalls for observation and sampling. At birth, 1, 4, and 24 h after birth, heart rate, respiratory rate, and rectal temperature were assessed and blood samples collected to measure indicators of pain and inflammation (cortisol, corticosterone, substance P, and haptoglobin). Serum IgG concentration and failed transfer of passive immunity (serum IgG concentration &amp;lt;24 g\/L) were assessed in the 24-h blood samples. Preweaning treatment for disease and mortality information was collected and calves were weighed at 7 to 10 d of age and at weaning. Of the 33 calves enrolled, 17 calves received meloxicam and 16 calves received a placebo. Meloxicam-medicated calves had significantly greater ADG to 7 to 10 d of age (P = 0.05) (mean = 0.9 kg\/d; SE = 0.10) compared with placebo-medicated calves (mean = 0.6 kg\/d; SE = 0.12). There was no significant effect of meloxicam on physiological indicators of pain and inflammation, standing or nursing by 1 h, passive immunity, health outcomes, or ADG to weaning (P &amp;gt; 0.1). Although this was a small sample population, meloxicam given to assisted calves at birth improved ADG in the first week of life, which may indicate an important production management tool for improving well-being in assisted calves.<\/jats:p>","DOI":"10.1093\/jas\/skz094","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T12:36:51Z","timestamp":1553171811000},"page":"1996-2008","source":"Crossref","is-referenced-by-count":22,"title":["Clinical impacts of administering a nonsteroidal anti-inflammatory drug to beef calves after assisted calving on pain and inflammation, passive immunity, health, and growth"],"prefix":"10.1093","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4481-8731","authenticated-orcid":false,"given":"Jennifer M","family":"Pearson","sequence":"first","affiliation":[{"name":"Department of Production Animal Health, University of Calgary Faculty of Veterinary Medicine, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmond A","family":"Pajor","sequence":"additional","affiliation":[{"name":"Department of Production Animal Health, University of Calgary Faculty of Veterinary Medicine, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences, University of Saskatchewan, Western College of Veterinary Medicine, Saskatoon, SK, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel A","family":"Caulkett","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical and Diagnostic Sciences, University of Calgary Faculty of Veterinary Medicine, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Production Animal Health, University of Calgary Faculty of Veterinary Medicine, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Dorin","sequence":"additional","affiliation":[{"name":"Veterinary Agri-Health Services Ltd., Airdrie, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Claire","family":"Windeyer","sequence":"additional","affiliation":[{"name":"Department of Production Animal Health, University of Calgary Faculty of Veterinary Medicine, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"2020071623232963900_CIT0001","doi-asserted-by":"crossref","first-page":"5194","DOI":"10.3168\/jds.2012-6251","article-title":"The effect of timing of oral meloxicam administration on physiological responses in calves after cautery dehorning with local anesthesia","volume":"96","author":"Allen","year":"2013","journal-title":"J. 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