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The objective of this study was to evaluate the effects of liquid feeding on growth performance, nutrient digestibility, and intestinal barrier functions during the early weaning period in pigs. Three hundred and sixty 24-d-old weanling pigs (Duroc \u00d7 Landrace \u00d7 Yorkshire) with BW of 6.98 \u00b1 0.15 kg were randomly assigned to a control diet (dry fed basal diet, CON) or as meal mixed with water in the ratio 1:4 (liquid fed basal diet, LF) with 6 replicates per treatment and 30 weanling pigs per replicate. The study lasted 7 d. On days 4 to 7, fresh fecal samples were collected to evaluate apparent total tract digestibility (ATTD) of nutrients. After 7 d, 2 weanling pigs per pen were euthanized and physiological samples were obtained. Results showed that LF increased (P &lt; 0.05) ADG (281 g vs. 183 g), ADFI (374 g vs. 245 g), and final BW (8.95 kg vs. 8.26 kg) compared with CON. Compared with CON, LF significantly decreased (P &lt; 0.05) serum cortisol and d-lactate concentrations as well as the activity of diamine oxidase, enhanced (P &lt; 0.05) the ATTD of ether extract and ash, increased (P &lt; 0.05) the activities of amylase, lipase, and lactase in the jejunal mucosa. Furthermore, LF had higher (P &lt; 0.05) villus height and villi height:crypt depth and increased (P &lt; 0.05) mRNA expressions of insulin-like growth factors-1 receptor (IGF-1R), claudin-2 (CLDN-2), zonula occludens-1 (ZO-1), and zonula occludens-2 (ZO-2) in the jejunum. Moreover, LF had lower (P &lt; 0.05) abundances of total bacteria and Escherichia coli and higher (P &lt; 0.05) concentrations of acetic acid and butyric acid in cecal digesta. Altogether, the results indicated that liquid feeding not only promoted growth performance but also improved intestinal health by enhancing gut barrier functions in weanling pigs.<\/jats:p>","DOI":"10.1093\/jas\/skz134","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T01:43:08Z","timestamp":1555983788000},"page":"2725-2738","source":"Crossref","is-referenced-by-count":14,"title":["Improvement of growth performance and parameters of intestinal function in liquid fed early weanling pigs1"],"prefix":"10.1093","volume":"97","author":[{"given":"Junjie","family":"Jiang","sequence":"first","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, and Key Laboratory of Animal Disease-resistant Nutrition, Sichuan Province, Ya\u2019an, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, and Key Laboratory of Animal Disease-resistant Nutrition, Sichuan Province, Ya\u2019an, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, and Key Laboratory of Animal Disease-resistant Nutrition, Sichuan Province, Ya\u2019an, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, and Key Laboratory of Animal Disease-resistant Nutrition, Sichuan Province, Ya\u2019an, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, and Key Laboratory of Animal Disease-resistant Nutrition, Sichuan Province, Ya\u2019an, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangbing","family":"Mao","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, and Key Laboratory of Animal Disease-resistant Nutrition, Sichuan Province, Ya\u2019an, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, and Key Laboratory of Animal Disease-resistant Nutrition, Sichuan Province, Ya\u2019an, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, and Key Laboratory of Animal Disease-resistant Nutrition, Sichuan Province, Ya\u2019an, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqiu","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, and Key Laboratory of Animal Disease-resistant Nutrition, Sichuan Province, Ya\u2019an, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"key":"2019070221124557400_CIT0001","article-title":"Official methods of analysis","author":"AOAC","year":"1995","edition":"16"},{"key":"2019070221124557400_CIT0002","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1093\/jn\/134.9.2256","article-title":"Weaning induces both transient and long-lasting modifications of absorptive, secretory, and barrier properties of piglet intestine","volume":"134","author":"Boudry","year":"2004","journal-title":"J. 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