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In total, 192 one-day-old male Ross 308 broiler chicks were randomly divided into four groups. This trial consisted of a 2\u2005\u00d7\u20052 factorial design with a diet factor (supplemented with 0 or 400 mg\/kg pterostilbene from 1 to 22 d of age) and a stress factor (intraperitoneally injected with saline or LPS at 5.0 mg\/kg BW at 21 da of age). The results showed that LPS challenge induced a decrease in BW gain (P\u2005&amp;lt;\u20050.001) of broilers during a 24-h period postinjection; however, this decrease was prevented by pterostilbene supplementation (P\u2005=\u20050.031). Administration of LPS impaired the intestinal integrity of broilers, as indicated by increased plasma diamine oxidase (DAO) activity (P\u2005=\u20050.014) and d-lactate content (P\u2005&amp;lt;\u20050.001), reduced jejunal villus height (VH; P\u2005&amp;lt;\u20050.001) and the ratio of VH to crypt depth (VH:CD; P\u2005&amp;lt;\u20050.001), as well as a decreased mRNA level of jejunal tight junction protein 1 (ZO-1; P\u2005=\u20050.002). In contrast, pterostilbene treatment increased VH:CD (P\u2005=\u20050.018) and upregulated the mRNA levels of ZO-1 (P\u2005=\u20050.031) and occludin (P\u2005=\u20050.024) in the jejunum. Consistently, pterostilbene counteracted the LPS-induced increased DAO activity (P\u2005=\u20050.011) in the plasma. In addition, the LPS-challenged broilers exhibited increases in nuclear accumulation of nuclear factor kappa B (NF-\u03baB) p65 (P\u2005&amp;lt;\u20050.001), the protein content of tumor necrosis factor \u03b1 (P\u2005=\u20050.033), and the mRNA abundance of IL-1\u03b2 (P\u2005=\u20050.042) and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3; P\u2005=\u20050.019). In contrast, pterostilbene inhibited the nuclear translocation of NF-\u03baB p65 (P\u2005=\u20050.039) and suppressed the mRNA expression of IL-1\u03b2 (P\u2005=\u20050.003) and NLRP3 (P\u2005=\u20050.049) in the jejunum. Moreover, pterostilbene administration induced a greater amount of reduced glutathione (P\u2005=\u20050.017) but a lower content of malondialdehyde (P\u2005=\u20050.023) in the jejunum of broilers compared with those received a basal diet. Overall, the current study indicates that dietary supplementation with pterostilbene may play a beneficial role in alleviating the intestinal damage of broiler chicks under the conditions of immunological stress.<\/jats:p>","DOI":"10.1093\/jas\/skz373","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T03:02:08Z","timestamp":1576033328000},"source":"Crossref","is-referenced-by-count":42,"title":["Dietary pterostilbene supplementation attenuates intestinal damage and immunological stress of broiler chickens challenged with lipopolysaccharide"],"prefix":"10.1093","volume":"98","author":[{"given":"Hao","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, Jiangsu, China"},{"name":"Postdoctoral Research Station of Clinical Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China"},{"name":"Shanghai Key Laboratory of Veterinary Biotechnology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueping","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, Jiangsu, China"},{"name":"Postdoctoral Research Station of Food Science and Engineering, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, Jiangsu Academy of Agricultural Sciences, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilu","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuli","family":"Ji","sequence":"additional","affiliation":[{"name":"College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"key":"2020012321393702900_CIT0001","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.taap.2006.12.025","article-title":"Resveratrol: a review of preclinical studies for human cancer prevention","volume":"224","author":"Athar","year":"2007","journal-title":"Toxicol. 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