{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:11:14Z","timestamp":1791853874884,"version":"4.3.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31902200"],"award-info":[{"award-number":["31902200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Presidential Foundation of the Guangdong Academy of Agricultural Sciences","award":["201802B"],"award-info":[{"award-number":["201802B"]}]},{"name":"Talent Project of the Guangdong Academy of Agricultural Sciences","award":["201803"],"award-info":[{"award-number":["201803"]}]},{"name":"Recommended Program of Guangdong","award":["2018kczx06"],"award-info":[{"award-number":["2018kczx06"]}]},{"name":"Guangdong Modern Agro-industry Technology Research System","award":["2019KJ115"],"award-info":[{"award-number":["2019KJ115"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFD0501210"],"award-info":[{"award-number":["2016YFD0501210"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology planning project of Guangdong Province","doi-asserted-by":"crossref","award":["2019A050505007"],"award-info":[{"award-number":["2019A050505007"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Program of Guangzhou","award":["201707010217"],"award-info":[{"award-number":["201707010217"]}]},{"name":"Science and Technology Program of Guangzhou","award":["201903010083"],"award-info":[{"award-number":["201903010083"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hermetia illucens larvae meal (HILM) are rich in proteins and chitin, and represent an innovative feed ingredient for animals. However, little is known about the intestinal bacteria and immune homeostasis response of HILM as a fishmeal replacement on weanling piglets. Thus, this study aimed to investigate the changes in specific ileal and cecal bacterial populations and their metabolic profiles, and ileal immune indexes in weanling piglets fed with a diet containing HILM. A total of 128 weanling piglets were fed either a basal diet or 1 of 3 diets with 1%, 2%, and 4% HILM (HI0, HI1, HI2, and HI4, respectively). Each group consisted of 8 pens (replicates), with 4 pigs per pen. After 28 d of feeding, 8 barrows per treatment were euthanized, the ileal and cecal digesta, and ileal mucosa were collected for analyzing bacterial population and metabolic profiles, and immune indexes, respectively. Results showed that HILM increased (P\u2005&amp;lt;\u20050.05, maximum in HI2) the number of Lactobacillus and Bifidobacterium in the ileum and cecum, but quadratically decreased (P\u2005&amp;lt;\u20050.05, minimum in HI2) the number of Escherichia coli. In the cecum, the number of Firmicutes, Ruminococcus, Clostridium cluster IV, and Prevotella showed a quadratic response to increasing (P\u2005&amp;lt;\u20050.05, maximum in HI2) HILM levels. Lactate and butyrate concentrations in the ileum and cecum were quadratically increased (P\u2005&amp;lt;\u20050.05, maximum in HI2) with increasing HILM levels. In the cecum, the amines, phenol, and indole compounds concentrations were quadratically decreased (P\u2005&amp;lt;\u20050.05, minimum in HI2) with increasing HILM levels, while total short-chain fatty acids and acetate concentrations were quadratically increased (P\u2005&amp;lt;\u20050.05, maximum in HI2). In the ileum, the TLR4, NF-\u03baB, MyD88, and TNF-\u03b1 mRNA expressions were quadratically decreased (P\u2005&amp;lt;\u20050.05, minimum in HI2) with increasing HILM levels, while the mRNA expression of IL-10, barrier function (MUC1, ZO-1, Occludin, and Claudin-2), and development-related genes (IGF-1, GLP-2, and EGF) was quadratically increased (P\u2005&amp;lt;\u20050.05, maximum in HI2). Furthermore, the changes in the mucosal gene expression were associated with changes in the bacterial populations and their metabolites. Collectively, these results showed that a diet supplemented with 2% HILM affected specific bacterial populations and metabolic profiles, and maintained ileal immune status. These findings provide new insights into the use of insect meal as a suitable alternative protein source for swine feeding.<\/jats:p>","DOI":"10.1093\/jas\/skz395","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T19:17:35Z","timestamp":1584645455000},"source":"Crossref","is-referenced-by-count":36,"title":["Hermetia illucens larvae as a Fishmeal replacement alters intestinal specific bacterial populations and immune homeostasis in weanling piglets"],"prefix":"10.1093","volume":"98","author":[{"given":"Miao","family":"Yu","sequence":"first","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Engineering Technology Research Center of Animal Meat quality and Safety Control and Evaluation, Guangzhou,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenming","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Engineering Technology Research Center of Animal Meat quality and Safety Control and Evaluation, Guangzhou,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Engineering Technology Research Center of Animal Meat quality and Safety Control and Evaluation, Guangzhou,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Engineering Technology Research Center of Animal Meat quality and Safety Control and Evaluation, Guangzhou,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Rong","sequence":"first","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Engineering Technology Research Center of Animal Meat quality and Safety Control and Evaluation, Guangzhou,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichang","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Engineering Technology Research Center of Animal Meat quality and Safety Control and Evaluation, Guangzhou,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyin","family":"Wang","sequence":"first","affiliation":[{"name":"Guangzhou AnRuiJie Environmental Protection Technology Co., Ltd., Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyong","family":"Ma","sequence":"first","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Engineering Technology Research Center of Animal Meat quality and Safety Control and Evaluation, Guangzhou,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,19]]},"reference":[{"key":"2020071315124950100_CIT0001","first-page":"G619","article-title":"Oral IGF-I enhances nutrient and electrolyte absorption in neonatal piglet intestine","volume":"277","author":"Alexander","year":"1999","journal-title":"Am. J. Physiol"},{"key":"2020071315124950100_CIT0002","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1172\/JCI30504","article-title":"CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease","volume":"117","author":"Barnich","year":"2007","journal-title":"J. Clin. Invest"},{"key":"2020071315124950100_CIT0003","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1177\/0148607104028004210","article-title":"Supplementation of total parenteral nutrition with butyrate acutely increases structural aspects of intestinal adaptation after an 80% jejunoileal resection in neonatal piglets","volume":"28","author":"Bartholome","year":"2004","journal-title":"J. Parenter. Enteral Nutr"},{"key":"2020071315124950100_CIT0004","doi-asserted-by":"crossref","first-page":"16269","DOI":"10.1038\/s41598-017-16560-6","article-title":"Insect-based diet, a promising nutritional source, modulates gut microbiota composition and SCFAs production in laying hens","volume":"7","author":"Borrelli","year":"2017","journal-title":"Sci. Rep"},{"key":"2020071315124950100_CIT0005","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.aquaculture.2018.01.006","article-title":"Characterisation of the intestinal microbial communities of rainbow trout (Oncorhynchus mykiss) fed with Hermetia illucens (black soldier fly) partially defatted larva meal as partial dietary protein source","volume":"487","author":"Bruni","year":"2018","journal-title":"Aquaculture"},{"key":"2020071315124950100_CIT0006","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/clinchem\/8.2.130","article-title":"Modified reagents for determination of urea and ammonia","volume":"8","author":"Chaney","year":"1962","journal-title":"Clin. Chem"},{"key":"2020071315124950100_CIT0007","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.3389\/fmicb.2018.01652","article-title":"Effects of intravenous infusion with sodium butyrate on colonic microbiota, intestinal development- and mucosal immune-related gene expression in normal growing pigs","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Microbiol"},{"key":"2020071315124950100_CIT0008","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.phrs.2012.11.005","article-title":"Re-print of \u201cIntestinal luminal nitrogen metabolism: Role of the gut microbiota and consequences for the host\u201d","volume":"68","author":"Davila","year":"2013","journal-title":"Pharmacol. Res"},{"key":"2020071315124950100_CIT0009","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1079\/NRR200369","article-title":"The combined use of triacylglycerols containing medium-chain fatty acids and exogenous lipolytic enzymes as an alternative to in-feed antibiotics in piglets: concept, possibilities and limitations. An overview","volume":"16","author":"Decuypere","year":"2003","journal-title":"Nutr. Res. Rev"},{"key":"2020071315124950100_CIT0010","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.aquaculture.2018.07.009","article-title":"Influence of Hermetia illucens meal dietary inclusion on the histological traits, gut mucin composition and the oxidative stress biomarkers in rainbow trout (Oncorhynchus mykiss)","volume":"496","author":"Elia","year":"2018","journal-title":"Aquaculture"},{"key":"2020071315124950100_CIT0011","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1079\/NRR200479","article-title":"Dietary modulation of the human colonic microbiota: updating the concept of prebiotics","volume":"17","author":"Gibson","year":"2004","journal-title":"Nutr. Res. Rev"},{"key":"2020071315124950100_CIT0012","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1126\/science.1223490","article-title":"Interactions between the microbiota and the immune system","volume":"336","author":"Hooper","year":"2012","journal-title":"Science"},{"key":"2020071315124950100_CIT0013","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.aquaculture.2018.10.034","article-title":"High-throughput sequencing of gut microbiota in rainbow trout (Oncorhynchus mykiss) fed larval and pre-pupae stages of black soldier fly (Hermetia illucens)","volume":"500","author":"Huyben","year":"2019","journal-title":"Aquaculture"},{"key":"2020071315124950100_CIT0014","doi-asserted-by":"crossref","first-page":"958","DOI":"10.5713\/ajas.14.0887","article-title":"Effects of dietary lycopene supplementation on plasma lipid profile, lipid peroxidation and antioxidant defense system in feedlot Bamei lamb","volume":"28","author":"Jiang","year":"2015","journal-title":"Asian-Australas. J. Anim. Sci"},{"key":"2020071315124950100_CIT0015","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/are.12867","article-title":"The effect of dietary chitin on growth and nutrient digestibility in farmed Atlantic cod, Atlantic salmon and Atlantic halibut","volume":"48","author":"Karlsen","year":"2017","journal-title":"Aquac. Res"},{"key":"2020071315124950100_CIT0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3382\/japr.2010-00162","article-title":"Effect of chitin and protein constituents in shrimp head meal on growth performance, nutrient digestibility, intestinal microbial populations, volatile fatty acids, and ammonia production in broilers","volume":"20","author":"Khempaka","year":"2011","journal-title":"J. Appl. Poult. Res"},{"key":"2020071315124950100_CIT0017","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1292\/jvms.17-0236","article-title":"Black soldier fly (Hermetia illucens) larvae enhances immune activities and increases survivability of broiler chicks against experimental infection of Salmonella gallinarum","volume":"80","author":"Lee","year":"2018","journal-title":"J. Vet. Med. Sci"},{"key":"2020071315124950100_CIT0018","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.fsi.2018.12.057","article-title":"Gut health and vaccination response in pre-smolt Atlantic salmon (Salmo salar) fed black soldier fly (Hermetia illucens) larvae meal","volume":"86","author":"Li","year":"2019","journal-title":"Fish Shellfish Immunol"},{"key":"2020071315124950100_CIT0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anifeedsci.2014.07.008","article-title":"State-of-the-art on use of insects as animal feed","volume":"197","author":"Makkar","year":"2014","journal-title":"Anim. Feed. Sci. Technol"},{"key":"2020071315124950100_CIT0020","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/1462-2920.12724","article-title":"Microbiome-metabolome analysis reveals unhealthy alterations in the composition and metabolism of ruminal microbiota with increasing dietary grain in a goat model","volume":"18","author":"Mao","year":"2016","journal-title":"Environ. Microbiol"},{"key":"2020071315124950100_CIT0021","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3389\/fmicb.2017.00797","article-title":"Differences in microbiota membership along the gastrointestinal tract of piglets and their differential alterations following an early-life antibiotic intervention","volume":"8","author":"Mu","year":"2017","journal-title":"Front. Microbiol"},{"key":"2020071315124950100_CIT0022","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jnutbio.2010.10.008","article-title":"Dietary modulation of clostridial cluster XIVa gut bacteria (Roseburia spp.) by chitin-glucan fiber improves host metabolic alterations induced by high-fat diet in mice","volume":"23","author":"Neyrinck","year":"2012","journal-title":"J. Nutr. Biochem"},{"key":"2020071315124950100_CIT0023","volume-title":"Nutrient requirements of swine","author":"NRC","year":"2012","edition":"11"},{"key":"2020071315124950100_CIT0024","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2527\/2006.841125x","article-title":"Performance responses and indicators of gastrointestinal health in early-weaned pigs fed low-protein amino acid-supplemented diets","volume":"84","author":"Nyachoti","year":"2006","journal-title":"J. Anim. Sci"},{"key":"2020071315124950100_CIT0025","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1053\/j.gastro.2004.11.050","article-title":"Lactobacillus and Bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles","volume":"128","author":"O\u2019Mahony","year":"2005","journal-title":"Gastroenterology"},{"key":"2020071315124950100_CIT0026","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1111\/1462-2920.13659","article-title":"Microbial nutrient niches in the gut","volume":"19","author":"Pereira","year":"2017","journal-title":"Environ. Microbiol"},{"key":"2020071315124950100_CIT0027","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1203\/00006450-200210000-00007","article-title":"Glucagon-like peptide 2 enhances maltase-glucoamylase and sucrase-isomaltase gene expression and activity in parenterally fed premature neonatal piglets","volume":"52","author":"Petersen","year":"2002","journal-title":"Pediatr. Res"},{"key":"2020071315124950100_CIT0028","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s40104-017-0191-3","article-title":"Evaluation of the suitability of a partially defatted black soldier fly (Hermetia illucens L.) larvae meal as ingredient for rainbow trout (Oncorhynchus mykiss Walbaum) diets","volume":"8","author":"Renna","year":"2017","journal-title":"J. Anim. Sci. Biotechnol"},{"key":"2020071315124950100_CIT0029","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1017\/S1751731113000062","article-title":"Impact of dietary protein on microbiota composition and activity in the gastrointestinal tract of piglets in relation to gut health: a review","volume":"7","author":"Rist","year":"2013","journal-title":"Animal"},{"key":"2020071315124950100_CIT0030","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1472-765X.2005.01709.x","article-title":"Susceptibility of Clostridium perfringens to C-C fatty acids","volume":"41","author":"Skrivanov\u00e1","year":"2005","journal-title":"Lett. Appl. Microbiol"},{"key":"2020071315124950100_CIT0031","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.anifeedsci.2017.08.012","article-title":"Gut antimicrobial effects and nutritional value of black soldier fly (Hermetia illucens L.) prepupae for weaned piglets","volume":"235","author":"Spranghers","year":"2018","journal-title":"Anim. Feed. Sci. Technol"},{"key":"2020071315124950100_CIT0032","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/19315260.2013.763317","article-title":"Assessing maturity of rotary barrel green waste composts for use as tomato and sweet pepper seedling starter and transplant growth substrates","volume":"20","author":"St. Martin","year":"2014","journal-title":"Int. J. Veg. Sci"},{"key":"2020071315124950100_CIT0033","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.fsi.2017.05.018","article-title":"Metagenomics analysis of gut microbiota and immune modulation in zebrafish (Danio rerio) fed chitosan silver nanocomposites","volume":"66","author":"Udayangani","year":"2017","journal-title":"Fish Shellfish Immunol"},{"key":"2020071315124950100_CIT0034","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-ento-120811-153704","article-title":"Potential of insects as food and feed in assuring food security","volume":"58","author":"van Huis","year":"2013","journal-title":"Annu. Rev. Entomol"},{"key":"2020071315124950100_CIT0035","first-page":"45","article-title":"Insects: a protein-rich feed ingredient in pig and poultry diets","volume":"5","author":"Veldkamp","year":"2015","journal-title":"Anim. Front"},{"key":"2020071315124950100_CIT0036","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/19490976.2018.1534512","article-title":"Opportunistic bacteria confer the ability to ferment prebiotic starch in the adult cystic fibrosis gut","volume":"10","author":"Wang","year":"2019","journal-title":"Gut Microbes"},{"key":"2020071315124950100_CIT0037","volume-title":"Effects of different dietary starches on intestinal functions and health and the underlying mechanism in weaned piglets","author":"Xiang","year":"2011"},{"key":"2020071315124950100_CIT0038","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/sj.gt.3300719","article-title":"The contribution of poly-L-lysine, epidermal growth factor and streptavidin to EGF\/PLL\/DNA polyplex formation","volume":"5","author":"Xu","year":"1998","journal-title":"Gene Ther"},{"key":"2020071315124950100_CIT0039","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/AEM.03174-15","article-title":"Bromochloromethane, a methane analogue, affects the microbiota and metabolic profiles of the rat gastrointestinal tract","volume":"82","author":"Yang","year":"2016","journal-title":"Appl. Environ. Microbiol"},{"key":"2020071315124950100_CIT0040","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1080\/00032719.2013.871550","article-title":"Determination of biogenic amines in digesta by high performance liquid chromatography with precolumn dansylation","volume":"47","author":"Yang","year":"2014","journal-title":"Anal. Lett"},{"key":"2020071315124950100_CIT0041","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cytogfr.2009.02.008","article-title":"Growth factor based therapies and intestinal disease: is glucagon-like peptide-2 the new way forward?","volume":"20","author":"Yazbeck","year":"2009","journal-title":"Cytokine Growth Factor Rev"},{"key":"2020071315124950100_CIT0042","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1007\/s00253-014-5792-6","article-title":"Insect antimicrobial peptides and their applications","volume":"98","author":"Yi","year":"2014","journal-title":"Appl. Microbiol. Biotechnol"},{"key":"2020071315124950100_CIT0043","doi-asserted-by":"crossref","first-page":"107837","DOI":"10.1016\/j.meatsci.2019.05.008","article-title":"Use of Hermetia illucens larvae as a dietary protein source: effects on growth performance, carcass traits, and meat quality in finishing pigs","volume":"158","author":"Yu","year":"2019","journal-title":"Meat. Sci"},{"key":"2020071315124950100_CIT0044","first-page":"3330","article-title":"Effects of Hermetia illucens L. larvae meal on nutrient digestibility, serum biochemical indices and amino acid composition of finishing pigs","volume":"31","author":"Yu","year":"2019","journal-title":"Chin. J. Anim. Nutr"},{"key":"2020071315124950100_CIT0045","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40104-019-0358-1","article-title":"Hermetia illucens larvae as a potential dietary protein source altered the microbiota and modulated mucosal immune status in the colon of finishing pigs","volume":"10","author":"Yu","year":"2019","journal-title":"J. Anim. Sci. Biotechnol"},{"key":"2020071315124950100_CIT0046","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.3389\/fmicb.2019.01143","article-title":"Microbiome-metabolomics analysis investigating the impacts of dietary starch types on the composition and metabolism of colonic microbiota in finishing pigs","volume":"10","author":"Yu","year":"2019","journal-title":"Front. Microbiol"},{"key":"2020071315124950100_CIT0047","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s00726-017-2451-0","article-title":"Increases in circulating amino acids with in-feed antibiotics correlated with gene expression of intestinal amino acid transporters in piglets","volume":"49","author":"Yu","year":"2017","journal-title":"Amino Acids"},{"key":"2020071315124950100_CIT0048","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s40104-017-0192-2","article-title":"Long-term effects of early antibiotic intervention on blood parameters, apparent nutrient digestibility, and fecal microbial fermentation profile in pigs with different dietary protein levels","volume":"8","author":"Yu","year":"2017","journal-title":"J. Anim. Sci. Biotechnol"},{"key":"2020071315124950100_CIT0049","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/1751-7915.13282","article-title":"Caecal infusion of the short-chain fatty acid propionate affects the microbiota and expression of inflammatory cytokines in the colon in a fistula pig model","volume":"11","author":"Zhang","year":"2018","journal-title":"Microb. Biotechnol"},{"key":"2020071315124950100_CIT0050","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3390\/md16020066","article-title":"Chitin oligosaccharide modulates gut microbiota and attenuates high-fat-diet-induced metabolic syndrome in mice","volume":"16","author":"Zheng","year":"2018","journal-title":"Mar. Drugs"}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jas\/article-pdf\/98\/3\/skz395\/33492502\/skz395.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jas\/article-pdf\/98\/3\/skz395\/33492502\/skz395.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T19:13:53Z","timestamp":1594667633000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/doi\/10.1093\/jas\/skz395\/5810268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,1]]},"references-count":50,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,19]]},"published-print":{"date-parts":[[2020,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jas\/skz395","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,3]]},"published":{"date-parts":[[2020,3,1]]},"article-number":"skz395"}}