{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:26:55Z","timestamp":1789622815474,"version":"build-2803163510"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>N-Ethylhexedrone [2-(ethyloamino)-1-phenylhexan-1-one; \u03b1-ethylaminohexanophenone (NEH)] is one of the most recent synthetic cathinones that appeared on the illegal market in late 2015. The majority of information concerning the model of consumption of NEH and its impact on the body originates only from self-reports from gray literature websites and drug forums. There are only limited data associated with the concentrations of NEH in blood samples available in the literature. This article presents a case of fatal NEH intoxication and a method for the determination of this substance in whole blood. A 21-year-old man without any diagnosed diseases was admitted to the hospital due to disorientation, aggression and finally loss of consciousness. Hyperthermia (&amp;gt;41\u00b0C), tachycardia (&amp;gt;160 beats per minute), tachypnea (20 breaths per minute), blood pressure (110\/60 mmHg) and acute kidney failure were diagnosed. After a few hours of hospitalization, the patient died. A plastic bag with a white powder was found in his underwear. Analysis of the powder by another laboratory revealed cocaine hydrochloride; however, no cocaine or its metabolites were found in the biological material upon testing in our laboratory. Therefore, re-analysis of the powder was performed, and NEH was identified. Liquid\u2013liquid extraction followed by liquid chromatography-triple quadrupole-mass spectrometry (LC-MS\/MS) analysis were used for the determination of NEH in blood. The validation parameters were as follows: calibration range 1\u2013250 ng\/mL, accuracy 106.5\u2013109.9%, precision 3.5\u20136.3%, recovery 90.1\u201396.9%, limit of detection 0.07 ng\/mL and limit of quantification 1 ng\/mL. NEH was quantified in the blood at a concentration of 145 ng\/mL. Additionally, amphetamine at low concentrations and 11-nor-9-karboksy-\u03949-tetrahydrokannabinol (THC-COOH) were detected.<\/jats:p>\n               <jats:p>Our study provided information on the possible lethal concentration and toxidrome that clinicians can observe for NEH-intoxicated patients and can be helpful during the preparation of toxicology analysis reports for a court of law for proper data interpretation.<\/jats:p>","DOI":"10.1093\/jat\/bkaa159","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T11:10:04Z","timestamp":1602241804000},"page":"e1-e6","source":"Crossref","is-referenced-by-count":17,"title":["Fatal <i>N<\/i>-Ethylhexedrone Intoxication"],"prefix":"10.1093","volume":"45","author":[{"given":"Ewa","family":"Domagalska","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Medicine, Medical University of Gda\u0144sk, 3A Marii Sk\u0142odowskiej-Curie Str., Gda\u0144sk 80-210, Pomeranian Voivodeship, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Banaszkiewicz","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemistry, Gda\u0144sk University of Technology, 11\/12 Narutowicza Str., Gda\u0144sk 80-233, Pomeranian Voivodeship, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz Kacper","family":"Wo\u017aniak","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemistry, Gda\u0144sk University of Technology, 11\/12 Narutowicza Str., Gda\u0144sk 80-233, Pomeranian Voivodeship, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"Kata","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Medicine, Medical University of Gda\u0144sk, 3A Marii Sk\u0142odowskiej-Curie Str., Gda\u0144sk 80-210, Pomeranian Voivodeship, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Szpiech","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Medicine, Medical University of Gda\u0144sk, 3A Marii Sk\u0142odowskiej-Curie Str., Gda\u0144sk 80-210, Pomeranian Voivodeship, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Kaliszan","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Medicine, Medical University of Gda\u0144sk, 3A Marii Sk\u0142odowskiej-Curie Str., Gda\u0144sk 80-210, Pomeranian Voivodeship, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"key":"2021071015265364700_R1","first-page":"53","article-title":"Determination of N-ethylhexedrone, a new cathinone derivative, in blood collected from drivers\u2013analysis of three cases","volume":"109","author":"Miko\u0142ajczyk","year":"2017","journal-title":"Probelms of Forensic Science"},{"key":"2021071015265364700_R2","volume-title":"European Monitoring for Drugs and Drug Addiction","author":"EMCDDA\u2013Europol 2016 Annual Report on the implementation of Council Decision 2005\/387\/JHA","year":"2016"},{"key":"2021071015265364700_R3","author":"Update on emerging substances of abuse. 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