{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:33:51Z","timestamp":1790670831821,"version":"4.1.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A 60-year-old man was found dead at home by his wife. The man was known to be a regular trainer in a fitness center and was described as a long-term user of anabolic steroids. The autopsy revealed heart failure with cardiomegaly, visceral congestion, and pulmonary edema. The local prosecutor ordered toxicological analyses but no anatomic pathology test. Initial analyses by the liquid chromatography coupled to quadrupole time-of-flight mass spectrometry system (UPLC--q-TOF-MS) system indicated the presence in femoral blood of trenbolone, an anabolic steroid. Trenbolone was quantified with a liquid chromatography system coupled with a tandem mass spectrometer in various autopsy specimens, including hair. Concentrations of trenbolone were 3.9, 3.2, 231, and lower than 0.5\u2009ng\/mL in femoral blood, cardiac blood, bile, and vitreous humor, respectively. Moreover, in head hair, the concentration was 9 pg\/mg. The presence of trenbolone in hair can be interpreted as repetitive exposures when compared to the limited literature data. Repetitive misuse of trenbolone can explain advanced heart failure. This paper highlights the importance of testing biological specimens for anabolic steroids in case of heart failure.<\/jats:p>","DOI":"10.1093\/jat\/bkab091","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T19:10:31Z","timestamp":1629313831000},"page":"e88-e91","source":"Crossref","is-referenced-by-count":9,"title":["Testing for Trenbolone, an Anabolic Steroid, in Biological Fluids and Head Hair in a Postmortem Case"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7804-3946","authenticated-orcid":false,"given":"Laurie","family":"Gheddar","sequence":"first","affiliation":[{"name":"Toxicologie, Institut de M\u00e9decine L\u00e9gale, 11 rue Humann, Strasbourg, Alsace 67000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"P\u00e9lissier","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine L\u00e9gale, Aix-Marseille Universit\u00e9, 27 boulevard Jean Moulin, Marseille, Provence-Alpes-C\u00f4te d\u2019Azur 13385, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Desfeux","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine L\u00e9gale, Aix-Marseille Universit\u00e9, 27 boulevard Jean Moulin, Marseille, Provence-Alpes-C\u00f4te d\u2019Azur 13385, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Niort","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine L\u00e9gale, Aix-Marseille Universit\u00e9, 27 boulevard Jean Moulin, Marseille, Provence-Alpes-C\u00f4te d\u2019Azur 13385, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-S\u00e9bastien","family":"Raul","sequence":"additional","affiliation":[{"name":"Toxicologie, Institut de M\u00e9decine L\u00e9gale, 11 rue Humann, Strasbourg, Alsace 67000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4174-5362","authenticated-orcid":false,"given":"Pascal","family":"Kintz","sequence":"additional","affiliation":[{"name":"Toxicologie, Institut de M\u00e9decine L\u00e9gale, 11 rue Humann, Strasbourg, Alsace 67000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"2022022406210709500_R1","volume-title":"Disposition of Toxic Drugs and Chemicals in Man","author":"Baselt","year":"2020","edition":"12th"},{"key":"2022022406210709500_R2","article-title":"Anti-Doping Testing Figures","author":"WADA","year":"2019"},{"key":"2022022406210709500_R3","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2165\/00023210-200519070-00002","article-title":"Behavioural manifestations of anabolic steroid use","volume":"19","author":"Trenton","year":"2005","journal-title":"CNS Drugs"},{"key":"2022022406210709500_R4","article-title":"Death after misuse of anabolic substances (clenbuterol, stanozolol and metandienone)","volume":"303","author":"Lehmen","year":"2019","journal-title":"Forensic Science International"},{"key":"2022022406210709500_R5","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/jat\/bkz058","article-title":"Complete post-mortem investigation in a death involving clenbuterol after long-term abuse","volume":"43","author":"Kintz","year":"2019","journal-title":"Journal of Analytical Toxicology"},{"key":"2022022406210709500_R6","first-page":"989","article-title":"Detection and quantification of 12 anabolic steroids anad analogs in human whole blood and 20 in hair using LC-HRMS\/MS: application to real cases","volume":"131","author":"Fabresse","year":"2017","journal-title":"International Journal ofLegalMedicine"},{"key":"2022022406210709500_R7","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2020.00435","article-title":"Identification of trenbolone metabolites using hydrogen isotope ratio mass spectrometry and liquid chromatography\/high accuracy\/ high resolution mass spectrometry for doping control analysis","volume":"8","author":"Putz","year":"2020","journal-title":"Frontiers in Chemistry"},{"key":"2022022406210709500_R8","article-title":"WADA Technical Document \u2013 TD2019MRPL","author":"WADA","year":"2019"},{"key":"2022022406210709500_R9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/B978-0-12-801700-5.00010-8","volume-title":"Hair Analysis in Clinical and Forensic Toxicology","author":"Thieme","year":"2015"},{"key":"2022022406210709500_R10","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/dta.3020","article-title":"Simultaneous testing for anabolic steroids in human hair specimens collected from various anatomic locations has several advantages when compared to the standard head hair analysis","volume":"13","author":"Kintz","year":"2021","journal-title":"Drug Testing and Analysis"},{"key":"2022022406210709500_R11","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2020.108660","article-title":"Anabolic steroid excess and myocardial infarction: from ischemia to reperfusion injury","volume":"161","author":"Seara","year":"2020","journal-title":"Steroids"},{"key":"2022022406210709500_R12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0033-0620(98)80019-4","article-title":"The cardiac toxicity of anabolic steroids","volume":"41","author":"Sullivan","year":"1998","journal-title":"Progress in Cardiovascular Diseases"},{"key":"2022022406210709500_R13","first-page":"43","article-title":"A young man with myocardial infarction due to trenbolone acetate; a case report","volume":"2","author":"Shahsavari Nia","year":"2014","journal-title":"Emergency"}],"container-title":["Journal of Analytical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jat\/advance-article-pdf\/doi\/10.1093\/jat\/bkab091\/40112340\/bkab091.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jat\/article-pdf\/46\/2\/e88\/42596016\/bkab091.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jat\/article-pdf\/46\/2\/e88\/42596016\/bkab091.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T06:21:41Z","timestamp":1645683701000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jat\/article\/46\/2\/e88\/6354953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,31]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,8,31]]},"published-print":{"date-parts":[[2022,2,24]]}},"URL":"https:\/\/doi.org\/10.1093\/jat\/bkab091","relation":{},"ISSN":["0146-4760","1945-2403"],"issn-type":[{"value":"0146-4760","type":"print"},{"value":"1945-2403","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,3,1]]},"published":{"date-parts":[[2021,8,31]]}}}