{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:30:27Z","timestamp":1780363827398,"version":"3.54.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A 30\u2009year old non-hispanic white male was found unresponsive at his workplace and admitted to the hospital in cardiac arrest. He was pronounced deceased shortly after arrival. At autopsy the pathologist noted a 176 pound, well-nourished, atraumatic, adult male with significant bilateral frothy pulmonary edema (right lung 930\u2009g and left lung 1,130\u2009g), cardiomegaly (430\u2009g), dilated ventricles and slight cerebral edema. Upon completion of the systematic toxicological analysis scope for the Franklin County Coroner\u2019s Office Toxicology Laboratory, no known drugs were found. Further review of the gas chromatography--mass spectrometry (GC--MS) full-scan library summary reports showed an unknown peak in both the blood and urine solid phase extracts. An analogue of \u03b1-pyrrolidinovalerophenone (\u03b1-PVP) was identified, and a GC--MS selected ion monitoring method was developed to identify and quantitate the presence of 4-fluoro-3-methyl-\u03b1-PVP. This method quantified the drug at 26\u2009ng\/mL in gray top femoral blood, 30\u2009ng\/mL in purple top heart blood and 20\u2009ng\/mL in red top vitreous humor. Qualitative presence was also observed in the urine but was not detected in the liver. The decedent\u2019s cause of death was determined to be due to fluoro-methyl-PVP toxicity and the manner was ruled to be accidental. Investigational follow-up interviews corroborated drug use by the deceased with a preference of research chemicals and synthetic cannabinoids via the internet. No published literature is available currently, and to the author\u2019s knowledge this is the first incident of a fatal death solely attributed to this substituted cathinone.<\/jats:p>","DOI":"10.1093\/jat\/bkac003","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T20:09:50Z","timestamp":1641845390000},"page":"e101-e104","source":"Crossref","is-referenced-by-count":19,"title":["Fatal Intoxication by the Novel Cathinone 4-Fluoro-3-methyl-\u03b1-PVP"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2954-7678","authenticated-orcid":false,"given":"Jennifer M","family":"Hobbs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca T","family":"DeRienz","sequence":"additional","affiliation":[{"name":"Franklin County Coroner\u2019s Office, Franklin County Forensics Science Center, 2090 Frank Road, Columbus, OH 43223, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D","family":"Baker","sequence":"additional","affiliation":[{"name":"Franklin County Coroner\u2019s Office, Franklin County Forensics Science Center, 2090 Frank Road, Columbus, OH 43223, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan R","family":"Shuttleworth","sequence":"additional","affiliation":[{"name":"Franklin County Coroner\u2019s Office, Franklin County Forensics Science Center, 2090 Frank Road, Columbus, OH 43223, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maneesha","family":"Pandey","sequence":"additional","affiliation":[{"name":"Franklin County Coroner\u2019s Office, Franklin County Forensics Science Center, 2090 Frank Road, Columbus, OH 43223, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"2022032114040774000_R1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/9781118850046","volume-title":"Drugs of Abuse Pharmacology and Molecular Mechanisms","author":"Howard","year":"2014","edition":"1st"},{"key":"2022032114040774000_R2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s13181-011-0193-z","article-title":"The toxicology of bath salts: a review of synthetic cathinones","volume":"8","author":"Prosser","year":"2012","journal-title":"Journal of Medical Toxicology"},{"key":"2022032114040774000_R3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/jat\/bks136","article-title":"Analysis of synthetic cathinones commonly found in bath salts in human performance and postmortem toxicology: method development, drug distribution, and interpretation of results","volume":"37","author":"Marinetti","year":"2013","journal-title":"Journal of Analytical Toxicology"},{"key":"2022032114040774000_R4","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/jat\/bkw029","article-title":"Twenty-one cases involving alpha-pyrrolidinovalerophenone (\u03b1-PVP)","volume":"40","author":"Wright","year":"2016","journal-title":"Journal of Analytical Toxicology"},{"key":"2022032114040774000_R5","article-title":"Controlled Substances - 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