{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:24:30Z","timestamp":1787009070763,"version":"build-2736575974"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This manuscript reported a fast and rapid qualitative screening method for abuse drugs in urine by liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS-MS). The scope of the abuse drugs under investigation included methamphetamine (MA), amphetamine (AMP), methylenedioxymethamphetamine (MDMA), methylenedioxyamphetamine (MDA), paramethoxymethamphetamine (PMMA), ephedrine, pseudoephedrine, ketamine (KET), deschloroketamine (DCK), 2-fluorodeschloroketamine (2\u2009F-DCK) and deschloro-N-ethylketamine (2-oxo-PCE). The method employed a dual mode extraction (DME) column as a novel clean-up method for the urine matrix. To an aliquot of 0.2\u2009mL urine, internal standards (ISTDs) and 0.4\u2009mL of acidified methanol were added. After vortex and centrifugation, the supernatant was passed through a DME column before LC\u2013MS-MS analysis. Chromatographic separation was achieved with a C18 column by gradient elution. The limits of detection (LODs) for MA, AMP, MDMA, MDA and PMMA were 3\u2009ng\/mL, whereas those for ephedrine and pseudoephedrine were 10\u2009ng\/mL and those for KET, DCK, 2\u2009F-DCK and 2-oxo-PCE were 1\u2009ng\/mL. The matrix effects ranged from \u221212% to 7% (%CV from 4% to 19%). This method is fit for the intended purpose for forensic toxicology, as well as for forensic analysis of drugs facilitating sexual assault and other criminal acts.<\/jats:p>","DOI":"10.1093\/jat\/bkac004","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T10:28:30Z","timestamp":1641983310000},"page":"1045-1052","source":"Crossref","is-referenced-by-count":9,"title":["Qualitative Screening of Amphetamine- and Ketamine-Type Abuse Drugs in Urine Employing Dual Mode Extraction Column by Liquid Chromatography\u2013Tandem Mass Spectrometry (LC\u2013MS-MS)"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3643-827X","authenticated-orcid":false,"given":"George Fai","family":"Wong","sequence":"first","affiliation":[{"name":"Forensic Science Division, Government Laboratory of Hong Kong, 7\/F, Ho Man Tin Government offices , 88 Chung Hau Street, Homantin, Hong 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