{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T22:43:18Z","timestamp":1780958598474,"version":"3.54.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Flualprazolam is a novel psychoactive substance in the benzodiazepine class that is increasing in prevalence in the USA. This study describes 19 cases of drivers stopped for impaired driving where flualprazolam was detected. This represents \u223c9% of the total cases submitted to the Sedgwick County Regional Forensic Science Center toxicology laboratory between July 2019 and May 2020. Blood concentrations of flualprazolam ranged from 4 to 69\u2009ng\/mL, with mean and median concentrations of 20.9\u2009ng\/mL and 15\u2009ng\/mL, respectively. The increased prevalence in which laboratories are detecting flualprazolam along with the low concentrations necessary for pharmacological effects illustrates the importance of laboratories to remain vigilant in testing for novel psychoactive substances.<\/jats:p>","DOI":"10.1093\/jat\/bkac019","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T04:19:13Z","timestamp":1647577153000},"page":"e191-e195","source":"Crossref","is-referenced-by-count":6,"title":["Driving Impairment Cases Involving Flualprazolam"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6698-7678","authenticated-orcid":false,"given":"Kimberly B","family":"Youso","sequence":"first","affiliation":[{"name":"Sedgwick County Regional Forensic Science Center, 1109 N. Minneapolis St. , Wichita, KS 67214, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei A","family":"Osawa","sequence":"additional","affiliation":[{"name":"Sedgwick County Regional Forensic Science Center, 1109 N. Minneapolis St. , Wichita, KS 67214, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina L","family":"Divine","sequence":"additional","affiliation":[{"name":"Sedgwick County Regional Forensic Science Center, 1109 N. Minneapolis St. , Wichita, KS 67214, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy P","family":"Rohrig","sequence":"additional","affiliation":[{"name":"Consultant in Pharmacology and Toxicology , Wichita, KS 67230, USA"},{"name":"Emporia State University, 1 Kellogg Circle , Emporia, KS 66801, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"key":"2022081310465598800_R1","volume-title":"6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines","author":"Hester","year":"1976"},{"key":"2022081310465598800_R2","article-title":"Flubromazolam","author":"Chem.eu"},{"key":"2022081310465598800_R3","article-title":"Flubromazolam","author":"Absolute Chems"},{"key":"2022081310465598800_R4","article-title":"Flualprazolam","volume-title":"Center for Forensic Science Research and Education and Temple University","author":"Krotulski","year":"2019"},{"key":"2022081310465598800_R5","article-title":"NPS Benzodiazepines in the United States. 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