{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T19:08:43Z","timestamp":1787252923794,"version":"build-2736575974"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100005289","name":"National Institute of Justice","doi-asserted-by":"publisher","award":["75-CX-0036"],"award-info":[{"award-number":["75-CX-0036"]}],"id":[{"id":"10.13039\/100005289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005289","name":"National Institute of Justice","doi-asserted-by":"publisher","award":["2019-MU-MU-007"],"award-info":[{"award-number":["2019-MU-MU-007"]}],"id":[{"id":"10.13039\/100005289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["P30 DA033934"],"award-info":[{"award-number":["P30 DA033934"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Presented is the analysis of four cannabinoid-based products. These products were part of a case involving visual and auditory hallucinations that precipitated the commission of a felony and subsequent arrest. The products were labeled to contain \u22068-tetrahydrocannabinol (\u22068-THC) or THC acetate (THC-O-A). Primary reference materials were not available for \u22068-THC-O-A, \u220610-THC-O-A, cannabidiol di-acetate (CBD-di-O-A) or respective deuterated internal standards. THC-O-A and CBD-di-O-A standards were prepared by derivatizing \u22068-THC, \u22069-THC, \u220610-THC, CBD, \u22069-THC-d3 and CBD-d3 using acetic anhydride. The cannabinoid-based products were determined to contain \u22068-THC, \u22068-THC-O-A, \u22069-THC-O-A and CBD-di-O-A and\/or other phytocannabinoids using three different analytical techniques. Direct analysis in real-time\u2013time-of-flight mass spectrometry was used for identifying exact masses. A gas chromatograph\u2013mass spectrometer was used for the identification of compounds and to quantitate THC-O-As in the products. A liquid chromatograph\u2013tandem mass spectrometer was used to identify and quantitate phytocannabinoids and CBD-di-O-A in the products. To the authors\u2019 knowledge, this is the first case report involving the identification of THC-O-As and CBD-di-O-A in commercially available products. Minimal clinical\/pharmacological data is available for these emerging synthetic cannabinoids\/novel psychoactive substances.<\/jats:p>","DOI":"10.1093\/jat\/bkac036","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T12:39:50Z","timestamp":1654691990000},"page":"940-948","source":"Crossref","is-referenced-by-count":37,"title":["\u22068-THC, THC-O Acetates and CBD-di-O Acetate: Emerging Synthetic Cannabinoids Found in Commercially Sold Plant Material and Gummy Edibles"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0474-6622","authenticated-orcid":false,"given":"Alaina K","family":"Holt","sequence":"first","affiliation":[{"name":"Department of Forensic Science, Virginia Commonwealth University , 1015 Floyd Avenue, Room 2015, Richmond, VA 23284, USA"},{"name":"Integrative Life Sciences Doctoral Program, Virginia Commonwealth University , PO Box 84230, Richmond, VA 23284, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5470-5717","authenticated-orcid":false,"given":"Justin L","family":"Poklis","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, Virginia Commonwealth University , PO Box 980613, Richmond, VA 23298, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle R","family":"Peace","sequence":"additional","affiliation":[{"name":"Department of Forensic Science, Virginia Commonwealth University , 1015 Floyd Avenue, Room 2015, Richmond, VA 23284, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"2022101415472351000_R1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/dta.1731","article-title":"Synthetic cannabimimetic agents metabolized by carboxylesterases","volume":"7","author":"Thomsen","year":"2015","journal-title":"Drug Testing and Analysis"},{"key":"2022101415472351000_R2","article-title":"Synthetic cannabinoids: What are they? 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