{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:26:16Z","timestamp":1790799976349,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The dead body of a 59-year-old man was found at his home by his father. The subject was naked in the corridor, wearing a black hood and a collar around the neck where a dog leash was attached. An empty syringe was discovered in the decedent\u2019s rectal vein. The autopsy revealed marked asphyxia signs with no indication of violence or trauma. Femoral blood, urine and hair (4\u2009cm, brown) were collected and submitted for comprehensive toxicological investigation. Initial screening did not indicate the presence of ethanol or any other over-the-counter or prescription pharmaceuticals. Routine toxicology screening by liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS-MS) tentatively identified only the cathinone stereoisomer(s), 3-methylmethcathinone (3-MMC) or mephedrone. Analysis by gas chromatography\u2013MS to distinguish between the isomers revealed the presence of 3-MMC, which was subsequently quantified by LC\u2013MS-MS. Femoral blood and urine concentrations were 1,437 and 16,733\u2009ng\/mL, respectively. In 4\u2009\u00d7\u20091-cm hair segments, 3-MMC was detected at &amp;lt;10 pg\/mg (limit of quantification). Further analysis by liquid chromatography\u2013high-resolution mass spectrometry (LC\u2013HRMS) allowed the identification of two metabolites in both blood and urine: desmethyl-3-MMC and hydroxyl-3-MMC. The pathologist established the cause of death in this case as acute 3-MMC poisoning in the context of ChemSex.<\/jats:p>","DOI":"10.1093\/jat\/bkac048","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T15:29:03Z","timestamp":1656516543000},"page":"949-955","source":"Crossref","is-referenced-by-count":17,"title":["Fatal Rectal Injection of 3-MMC in a Sexual Context: Toxicological Investigations Including Metabolites Identification Using LC\u2013HRMS"],"prefix":"10.1093","volume":"46","author":[{"given":"Fr\u00e9d\u00e9ric","family":"Aknouche","sequence":"first","affiliation":[{"name":"Laboratoire Barla , 6 rue Barla, Nice 06000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1117-0887","authenticated-orcid":false,"given":"Alice","family":"Ameline","sequence":"additional","affiliation":[{"name":"Institut de m\u00e9decine l\u00e9gale , 11 rue Humann, Strasbourg 67000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7804-3946","authenticated-orcid":false,"given":"Laurie","family":"Gheddar","sequence":"additional","affiliation":[{"name":"Institut de m\u00e9decine l\u00e9gale , 11 rue Humann, Strasbourg 67000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Maruejouls","sequence":"additional","affiliation":[{"name":"Laboratoire Barla , 6 rue Barla, Nice 06000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4174-5362","authenticated-orcid":false,"given":"Pascal","family":"Kintz","sequence":"additional","affiliation":[{"name":"Institut de m\u00e9decine l\u00e9gale , 11 rue Humann, Strasbourg 67000, France"},{"name":"X-Pertise Consulting , 42 rue principale, Mittelhausbergen 67206, 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