{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:24:34Z","timestamp":1787009074963,"version":"build-2736575974"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>3-Hydroxyphencyclidine (3-OH-PCP) is a hydroxy derivative of phencyclidine, synthesized in 1978 to investigate the structure\u2013activity relationship of phencyclidine derivates. In vitro studies have shown that 3-OH-PCP, like phencyclidine, acts on the N-methyl-D-aspartate receptor and has a higher affinity for this receptor than phencyclidine. The authors report the case of a 38-year-old man, known for drug addiction, found dead at home with two plastic bags of powders found near his body. Using liquid chromatography coupled to tandem mass spectrometry, peripheral blood toxicological analysis revealed consumption of 3-OH-PCP with a concentration of 3-OH-PCP being 524\u2009ng\/mL. Blood also tested positive for nordiazepam, methylphenidate, amisulpride, methadone and benzoylecgonine, all at concentrations near those observed after recreational abuse. The blood concentration of 3-OH-PCP is the highest ever reported in the literature. Hair testing also revealed 3-OH-PCP, at 174\u2009pg\/mg, which may correspond to a chronic consumption of this molecule. A nuclear magnetic resonance analysis of the two powders highlighted 3-OH-PCP and 5-methoxy-dimethyltryptamine, estimated to have a purity of 85.4 and 91.3%, respectively, using the Electronic Reference To access In vivo Concentrations method.<\/jats:p>","DOI":"10.1093\/jat\/bkad031","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T11:38:51Z","timestamp":1686137931000},"page":"552-556","source":"Crossref","is-referenced-by-count":2,"title":["Case report of\u00a0a fatal 3-hydroxyphencyclidine intoxication, including blood and\u00a0hair results"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1117-0887","authenticated-orcid":false,"given":"Alice","family":"Ameline","sequence":"first","affiliation":[{"name":"Institut de m\u00e9decine l\u00e9gale , 11 rue Humann, Strasbourg 67000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgane","family":"Baudry","sequence":"additional","affiliation":[{"name":"Institut de m\u00e9decine l\u00e9gale , 11 rue Humann, Strasbourg 67000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Garnier","sequence":"additional","affiliation":[{"name":"Laboratoire de Conception et Application de Mol\u00e9cules Bioactives , UMR 7199, Illkirch-Graffenstaden 67400, France"},{"name":"Plateforme d\u2019Analyse Chimique de Strasbourg-Illkirch , Illkirch-Graffenstaden 67400, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-S\u00e9bastien","family":"Raul","sequence":"additional","affiliation":[{"name":"Institut de m\u00e9decine l\u00e9gale , 11 rue Humann, Strasbourg 67000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4174-5362","authenticated-orcid":false,"given":"Pascal","family":"Kintz","sequence":"additional","affiliation":[{"name":"Institut de m\u00e9decine l\u00e9gale , 11 rue Humann, Strasbourg 67000, France"},{"name":"X-Pertise Consulting , 42 rue Principale, Mittelhausbergen 67206, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"2023072218584766300_R1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/10408448209041322","article-title":"Phencyclidine (PCP): a review and\u00a0perspectives","volume":"10","author":"Aniline","year":"1982","journal-title":"Critical Reviews in Toxicology"},{"key":"2023072218584766300_R2","article-title":"Convention on\u00a0Psychotropic Substances","volume-title":"United Nations, Treaty Series, vol. 1019, p. 175. CHAPTER VI. Narcotic Drugs and Psychotropic Substances (un.org)","author":"United Nations Treaty Collection"},{"key":"2023072218584766300_R3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1021\/jm00346a019","article-title":"Chemical synthesis and\u00a0molecular pharmacology of\u00a0hydroxylated 1-(1-phenylcyclohexyl-piperidine derivatives)","volume":"25","author":"Kamenka","year":"1982","journal-title":"Journal of Medicinal Chemistry"},{"key":"2023072218584766300_R4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0014-2999(96)00382-2","article-title":"Autoradiographic study on\u00a0the pharmacological characteristics of\u00a0[3H]3-OH-PCP binding sites in\u00a0rat brain","volume":"10","author":"Suzuki","year":"1996","journal-title":"European Journal of Pharmacology"},{"key":"2023072218584766300_R5","first-page":"173","article-title":"High and\u00a0low affinity psychotomimetic opioid binding sites: characterization by a novel 3H-PCP-analog","volume":"75","author":"Itzhak","year":"1986","journal-title":"NIDA Research Monograph"},{"key":"2023072218584766300_R6","article-title":"3-OH-PCP: Tripsit 2019","author":"Tripsit"},{"key":"2023072218584766300_R7","article-title":"3-OH-PCP. 3-OH-PCP \u2013 PsychonautWiki","author":"Psychonaut Wiki"},{"key":"2023072218584766300_R8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s13181-019-00734-x","article-title":"Severe toxicity of\u00a0the new psychoactive substances 3-hydroxyphencyclidine and\u00a0N-ethylhexedrone: an analytically confirmed case report","volume":"16","author":"Dunlop","year":"2020","journal-title":"Journal of Medical Toxicology"},{"key":"2023072218584766300_R9","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/dta.2807","article-title":"In vitro and\u00a0in vivo metabolism and\u00a0detection of\u00a03-OH-PCP, a synthetic phencyclidine, in\u00a0human samples and\u00a0pooled human hepatocytes using high resolution mass spectrometry","volume":"12","author":"Bork","year":"2020","journal-title":"Drug Testing and Analysis"},{"key":"2023072218584766300_R10","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1021\/ac981422i","article-title":"Concentration measurement by proton NMR using the ERETIC method","volume":"71","author":"Akoka","year":"1999","journal-title":"Analytical Chemistry"},{"key":"2023072218584766300_R11","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/dta.2564","article-title":"Testing of\u00a0AB-PINACA in\u00a0human hair: distribution in\u00a0head hair versus pubic haire","volume":"11","author":"Arbouche","year":"2019","journal-title":"Drug Testing and Analysis"},{"key":"2023072218584766300_R12","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.forsciint.2017.10.020","article-title":"Structural characterization of\u00a0new synthetic cannabinoids CUMYL-PINACA, 5F-CUMYL-PINACA, CUMYL-4CN-BINACA, 5F-CUMYL-P7AICA and\u00a0CUMYL-4CN-B7AICA","volume":"281","author":"Bovens","year":"2017","journal-title":"Forensic Science International"},{"key":"2023072218584766300_R13","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/dta.2366","article-title":"Prediction of\u00a0designer drugs: synthesis and\u00a0spectroscopic analysis of\u00a0synthetic cathinone analogs that may appear on\u00a0the Swedish drug market","volume":"10","author":"Carlsson","year":"2018","journal-title":"Drug Testing and Analysis"},{"key":"2023072218584766300_R14","article-title":"Revisited: therapeutic and\u00a0toxic blood concentrations of\u00a0more than 1,100 drugs and\u00a0other xenobiotics","volume":"24","author":"Schulz","year":"2020","journal-title":"Critical Care"},{"key":"2023072218584766300_R15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1177\/096032718300200301","article-title":"A collection of\u00a0therapeutic, toxic and\u00a0fatal blood drug concentrations in\u00a0man","volume":"2","author":"Stead","year":"1983","journal-title":"Human Toxicology"},{"key":"2023072218584766300_R16","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1520\/JFS13406J","article-title":"Analysis of\u00a0phencyclidine and\u00a0cocaine in\u00a0human hair by tandem mass spectrometry","volume":"38","author":"Kidwell","year":"1993","journal-title":"Journal of Forensic Sciences"},{"key":"2023072218584766300_R17","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1520\/JFS11402J","article-title":"Detection of\u00a0phencyclidine in\u00a0hair","volume":"26","author":"Baumgartner","year":"1981","journal-title":"Journal of Forensic Sciences"},{"key":"2023072218584766300_R18","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1176\/ajp.142.8.950","article-title":"Hair analysis for\u00a0detection of\u00a0phencyclidine in\u00a0newly admitted psychiatric patients","volume":"142","author":"Sramek","year":"1985","journal-title":"The American Journal of Psychiatry"}],"container-title":["Journal of Analytical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jat\/advance-article-pdf\/doi\/10.1093\/jat\/bkad031\/50621881\/bkad031.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jat\/article-pdf\/47\/6\/552\/50936474\/bkad031.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jat\/article-pdf\/47\/6\/552\/50936474\/bkad031.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T14:59:07Z","timestamp":1690037947000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jat\/article\/47\/6\/552\/7190897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,6]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6,6]]},"published-print":{"date-parts":[[2023,7,22]]}},"URL":"https:\/\/doi.org\/10.1093\/jat\/bkad031","relation":{},"ISSN":["0146-4760","1945-2403"],"issn-type":[{"value":"0146-4760","type":"print"},{"value":"1945-2403","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,7,1]]},"published":{"date-parts":[[2023,6,6]]}}}