{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:01:47Z","timestamp":1787583707396,"version":"build-2736575974"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3302003"],"award-info":[{"award-number":["2022YFC3302003"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Forensic Service Platform","award":["19DZ2292700"],"award-info":[{"award-number":["19DZ2292700"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271932"],"award-info":[{"award-number":["82271932"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Key Laboratory of Forensic Medicine","award":["21DZ2270800"],"award-info":[{"award-number":["21DZ2270800"]}]},{"name":"Yunnan Province Science and Technology","award":["202301AS070037"],"award-info":[{"award-number":["202301AS070037"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3302003"],"award-info":[{"award-number":["2022YFC3302003"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Forensic Service Platform","award":["19DZ2292700"],"award-info":[{"award-number":["19DZ2292700"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271932"],"award-info":[{"award-number":["82271932"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Key Laboratory of Forensic Medicine","award":["21DZ2270800"],"award-info":[{"award-number":["21DZ2270800"]}]},{"name":"Yunnan Province Science and Technology","award":["202301AS070037"],"award-info":[{"award-number":["202301AS070037"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Amatoxins and phallotoxins are toxic cyclopeptides found in the genus Amanita and are among the predominant causes of foodborne sickness and poisoning-related fatalities in China. This study introduces and validates a simple, rapid and cost-effective ultra-performance liquid chromatography\u2013mass spectrometry method for the simultaneous determination and quantification of \u03b1-amanitin, \u03b2-amanitin, \u03b3-amanitin, phallisacin, phallacidin and phalloidin in human blood and urine. Quick therapeutic decision-making is supported by a 9\u2009min chromatographic separation performed on a Waters Acquity UPLC HSS T3 column (100\u2009mm\u2009\u00d7\u20092.1\u2009mm, 1.8\u2009\u00b5m) using a gradient of high-performance liquid chromatography (HPLC)-grade water and methanol:0.005% formic acid. The analyte limit of quantification was 1\u20133\u2009ng\/mL in blood and 0.5\u20132\u2009ng\/mL in urine. Calibrations curves, prepared by spiking drug-free blood and urine, demonstrated acceptable linearity with mean correlation coefficients (r) greater than 0.99 for all phallotoxins and amatoxins. Acceptable intraday and interday precision (relative standard deviation &amp;lt;15%) and accuracy (bias, \u22124.8% to 13.0% for blood and\u20149.0% to 14.7% for urine) were achieved. The validated method was successfully applied to analyze 9 blood samples and 2 urine samples testing positive for amatoxins and\/or phallotoxins. Amatoxins and\/or phallotoxins were identified in each whole blood sample at a range of 1.12\u20135.63\u2009ng\/mL and in two urine samples from 1.01\u20139.27\u2009ng\/mL. The method has the benefits of simple sample preparation (protein precipitation) and wide analyte coverage, making it suitable for emergency quantitative surveillance toxicological analysis in clinics and forensic poisoning practice.<\/jats:p>","DOI":"10.1093\/jat\/bkad081","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T12:29:06Z","timestamp":1699273746000},"page":"44-53","source":"Crossref","is-referenced-by-count":5,"title":["Simple and\u00a0rapid detection of\u00a0three amatoxins and\u00a0three phallotoxins in\u00a0human body fluids by UPLC\u2013MS-MS and\u00a0its application in\u00a015 poisoning cases"],"prefix":"10.1093","volume":"48","author":[{"given":"Shuo","family":"Yang","sequence":"first","affiliation":[{"name":"Academy of Forensic science, Shanghai Key Laboratory of Forensic Medicine , No. 1347 Guangfuxi Road, Shanghai 200063, China"},{"name":"School of Pharmacy, China Pharmaceutical University , No. 639 Longmian Avenue, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wen","sequence":"additional","affiliation":[{"name":"College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification , No. 361 Zhongshan East Road, Shijiazhuang 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenshuang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Yunnan University (Yunnan Second People\u2019s Hospital, Yunnan Eye Hospital) , No. 176 Qingnian Road, Kunming 650021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanbai","family":"Pu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Yunnan University (Yunnan Second People\u2019s Hospital, Yunnan Eye Hospital) , No. 176 Qingnian Road, Kunming 650021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuonan","family":"Chen","sequence":"additional","affiliation":[{"name":"Academy of Forensic science, Shanghai Key Laboratory of Forensic Medicine , No. 1347 Guangfuxi Road, Shanghai 200063, China"},{"name":"School of Pharmacy, China Pharmaceutical University , No. 639 Longmian Avenue, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mobing","family":"Chen","sequence":"additional","affiliation":[{"name":"Academy of Forensic science, Shanghai Key Laboratory of Forensic Medicine , No. 1347 Guangfuxi Road, Shanghai 200063, China"},{"name":"School of Pharmacy, China Pharmaceutical University , No. 639 Longmian Avenue, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Di","sequence":"additional","affiliation":[{"name":"School of Pharmacy, China Pharmaceutical University , No. 639 Longmian Avenue, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Academy of Forensic science, Shanghai Key Laboratory of Forensic Medicine , No. 1347 Guangfuxi Road, Shanghai 200063, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5525-1048","authenticated-orcid":false,"given":"Yan","family":"Shi","sequence":"additional","affiliation":[{"name":"Academy of Forensic science, Shanghai Key Laboratory of Forensic Medicine , No. 1347 Guangfuxi Road, Shanghai 200063, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"2024020109375062200_R1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.46234\/ccdcw2023.009","article-title":"Mushroom poisoning outbreaks - China, 2021","volume":"4","author":"Li","year":"2022","journal-title":"China CDC Wkly"},{"key":"2024020109375062200_R2","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.toxicon.2018.11.007","article-title":"Mushroom poisoning: A proposed new clinical classification","volume":"157","author":"White","year":"2019","journal-title":"Toxicon"},{"key":"2024020109375062200_R3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0041-0101(97)00074-3","article-title":"Toxins of\u00a0Amanita phalloides","volume":"36","author":"Vetter","year":"1998","journal-title":"Toxicon"},{"key":"2024020109375062200_R4","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.wem.2015.08.002","article-title":"A case study: what doses of\u00a0amanita phalloides and\u00a0amatoxins are lethal to humans?","volume":"26","author":"Yilmaz","year":"2015","journal-title":"Wilderness & Environmental Medicine"},{"key":"2024020109375062200_R5","doi-asserted-by":"publisher","first-page":"518","DOI":"10.46234\/ccdcw2021.134","article-title":"Mushroom Poisoning Outbreaks - China, 2010-2020","volume":"3","author":"Li","year":"2021","journal-title":"China CDC Wkly"},{"key":"2024020109375062200_R6","volume-title":"Critical Care Toxicology: Diagnosis and Management of the Critically Poisoned Patient","author":"Zilker","year":"2017"},{"key":"2024020109375062200_R7","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3109\/15563659309000374","article-title":"Kinetics of\u00a0amatoxins in\u00a0human poisoning: therapeutic implications","volume":"31","author":"Jaeger","year":"1993","journal-title":"Journal of Toxicology. Clinical Toxicology"},{"key":"2024020109375062200_R8","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1007\/s00216-004-2663-5","article-title":"A highly sensitive and\u00a0specific enzyme immunoassay for\u00a0detection of\u00a0beta-amanitin in\u00a0biological fluids","volume":"379","author":"Abuknesha","year":"2004","journal-title":"Analytical and Bioanalytical Chemistry"},{"key":"2024020109375062200_R9","doi-asserted-by":"publisher","first-page":"4979","DOI":"10.1007\/s00216-021-03457-7","article-title":"Production of\u00a0highly sensitive monoclonal antibody and\u00a0development of\u00a0lateral flow assays for\u00a0phallotoxin detection in\u00a0urine","volume":"413","author":"Zhu","year":"2021","journal-title":"Analytical and Bioanalytical Chemistry"},{"key":"2024020109375062200_R10","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1081\/CLT-200035472","article-title":"Diagnostic accuracy of\u00a0urinary amanitin in\u00a0suspected mushroom poisoning: a pilot study","volume":"42","author":"Butera","year":"2004","journal-title":"Journal of Toxicology. Clinical Toxicology"},{"key":"2024020109375062200_R11","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.jpba.2008.03.032","article-title":"Determination of\u00a0alpha- and\u00a0beta-amanitin in\u00a0clinical urine samples by capillary zone electrophoresis","volume":"47","author":"Robinson-Fuentes","year":"2008","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"2024020109375062200_R12","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0021-9673(96)00173-2","article-title":"Analysis of\u00a0amatoxins alpha-amanitin and\u00a0beta-amanitin in\u00a0toadstool extracts and\u00a0body fluids by capillary zone electrophoresis with photodiode array detection","volume":"744","author":"Br\u00fcggemann","year":"1996","journal-title":"Journal of Chromatography. A"},{"key":"2024020109375062200_R13","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1093\/clinchem\/32.9.1751","article-title":"Radioimmunoassay for\u00a0amatoxins by use of\u00a0a rapid, 125I-tracer-based system","volume":"32","author":"Andres","year":"1986","journal-title":"Clinical Chemistry"},{"key":"2024020109375062200_R14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.aca.2013.08.044","article-title":"Development, optimization and\u00a0application of\u00a0an analytical methodology by ultra performance liquid chromatography-tandem mass spectrometry for\u00a0determination of\u00a0amanitins in\u00a0urine and\u00a0liver samples","volume":"799","author":"Leite","year":"2013","journal-title":"Analytica Chimica Acta"},{"key":"2024020109375062200_R15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.toxicon.2018.07.025","article-title":"Detection of\u00a0\u03b1-, \u03b2-, and\u00a0\u03b3-amanitin in\u00a0urine by LC\u2013MS-MS using (15)N(10)-\u03b1-amanitin as the internal standard","volume":"152","author":"Abbott","year":"2018","journal-title":"Toxicon"},{"key":"2024020109375062200_R16","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0378-4347(00)00270-X","article-title":"Validated electrospray liquid chromatographic-mass spectrometric assay for\u00a0the determination of\u00a0the mushroom toxins alpha- and\u00a0beta-amanitin in\u00a0urine after immunoaffinity extraction","volume":"748","author":"Maurer","year":"2000","journal-title":"Journal of Chromatography. B, Biomedical Sciences and Applications"},{"key":"2024020109375062200_R17","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8050128","article-title":"A simple and\u00a0high-throughput analysis of\u00a0amatoxins and\u00a0phallotoxins in\u00a0human plasma, serum and\u00a0urine using LC\u2013MS-MS Combined with PRiME HLB \u03bcElution platform","volume":"8","author":"Zhang","year":"2016","journal-title":"Toxins (Basel)"},{"key":"2024020109375062200_R18","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3724\/SP.J.1123.2021.08018","article-title":"[Highly sensitive determination of\u00a0three kinds of\u00a0amanitins in\u00a0urine and\u00a0plasma by ultra performance liquid chromatography-triple quadrupole mass spectrometry coupled with immunoaffinity column clean-up]","volume":"40","author":"Zhang","year":"2022","journal-title":"Se Pu"},{"key":"2024020109375062200_R19","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.127394","article-title":"Reverse-phase\/phenylboronic-acid-type magnetic microspheres to eliminate the matrix effects in\u00a0amatoxin and\u00a0phallotoxin determination via ultrahigh-performance liquid chromatography-tandem mass spectrometry","volume":"332","author":"Xu","year":"2020","journal-title":"Food Chemistry"},{"key":"2024020109375062200_R20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1093\/jat\/bku035","article-title":"Amatoxins (\u03b1- and\u00a0\u03b2-Amanitin) and\u00a0phallotoxin (Phalloidin) analyses in\u00a0urines using high-resolution accurate mass LC\u2013MS technology","volume":"38","author":"Gicquel","year":"2014","journal-title":"Journal of Analytical Toxicology"},{"key":"2024020109375062200_R21","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.120847","article-title":"Development and\u00a0application of\u00a0a strategy for\u00a0analyzing eight biomarkers in\u00a0human urine to verify toxic mushroom or ricinus communis ingestions by means of\u00a0hydrophilic interaction LC coupled to HRMS\/MS","volume":"213","author":"Bambauer","year":"2020","journal-title":"Talanta"},{"key":"2024020109375062200_R22","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s11419-012-0145-6","article-title":"MALDI-TOF mass spectrometric analysis of\u00a0\u03b1-amanitin, \u03b2-amanitin, and\u00a0phalloidin in\u00a0urine","volume":"30","author":"Gonmori","year":"2012","journal-title":"Forensic Toxicology"},{"key":"2024020109375062200_R23","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.bios.2015.03.005","article-title":"Selective fluorescent sensing of\u00a0\u03b1-amanitin in\u00a0serum using carbon quantum dots-embedded specificity determinant imprinted polymers","volume":"69","author":"Feng","year":"2015","journal-title":"Biosensors & Bioelectronics"},{"key":"2024020109375062200_R24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0378-4347(88)80012-4","article-title":"High-performance liquid chromatographic method for\u00a0the determination of\u00a0alpha-amanitin and\u00a0phalloidin in\u00a0human plasma using the column-switching technique and\u00a0its application in\u00a0suspected cases of\u00a0poisoning by the green species of\u00a0amanita mushroom (Amanita phalloides)","volume":"425","author":"Rieck","year":"1988","journal-title":"Journal of Chromatography"},{"key":"2024020109375062200_R25","first-page":"672","article-title":"Determination of\u00a0[alpha]-amanitin in\u00a0human serum by solid-phase extraction coupled with HPLC\u2013UV","volume":"29","author":"Zhou","year":"2011","journal-title":"LC-GC North America"},{"key":"2024020109375062200_R26","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s11419-010-0098-6","article-title":"Simple analysis of\u00a0\u03b1-amanitin and\u00a0\u03b2-amanitin in\u00a0human plasma by liquid chromatography-mass spectrometry","volume":"28","author":"Tanahashi","year":"2010","journal-title":"Forensic Toxicology"},{"key":"2024020109375062200_R27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2020.113523","article-title":"Analytical method development for\u00a0\u03b1-amanitin and\u00a0\u03b2-amanitin in\u00a0plasma at ultra-trace level by online solid phase extraction-high performance liquid chromatography-triple quadrupole mass spectrometry and\u00a0its application in\u00a0poisoning events","volume":"190","author":"Xu","year":"2020","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"2024020109375062200_R28","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s11419-012-0146-5","article-title":"Simple and\u00a0rapid analysis of\u00a0amatoxins using LC\u2013MS-MS","volume":"30","author":"Nomura","year":"2012","journal-title":"Forensic Toxicology"},{"key":"2024020109375062200_R29","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.1021\/jf063194w","article-title":"Determination of\u00a0alpha-amanitin in\u00a0serum and\u00a0liver by multistage linear ion trap mass spectrometry","volume":"55","author":"Filigenzi","year":"2007","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"2024020109375062200_R30","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12110671","article-title":"Analysis of\u00a0\u03b1- and\u00a0\u03b2-amanitin in\u00a0human plasma at subnanogram per milliliter levels by reversed phase ultra-high performance liquid chromatography coupled to orbitrap mass spectrometry","volume":"12","author":"Bambauer","year":"2020","journal-title":"Toxins (Basel)"},{"key":"2024020109375062200_R31","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jchromb.2015.06.001","article-title":"Quantification of\u00a0alpha-amanitin in\u00a0biological samples by HPLC using simultaneous UV- diode array and\u00a0electrochemical detection","volume":"997","author":"Garcia","year":"2015","journal-title":"Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences"},{"key":"2024020109375062200_R32","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1080\/15287394.2021.1944942","article-title":"Pharmacokinetics of\u00a0\u03b1-amanitin in\u00a0mice using liquid chromatography-high resolution mass spectrometry and\u00a0in vitro drug-drug interaction potentials","volume":"84","author":"Park","year":"2021","journal-title":"Journal of Toxicology and Environmental Health. Part A"},{"key":"2024020109375062200_R33","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s11419-011-0115-4","article-title":"Mushroom toxins: a forensic toxicological review","volume":"29","author":"Gonmori","year":"2011","journal-title":"Forensic Toxicology"},{"key":"2024020109375062200_R34","first-page":"396","article-title":"Guideline on\u00a0bioanalytical method validation","volume":"35","author":"Agency","year":"2012","journal-title":"Drug Evaluation Research"},{"key":"2024020109375062200_R35","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0378-4347(97)00514-8","article-title":"Liquid chromatography-mass spectrometry in\u00a0forensic and\u00a0clinical toxicology","volume":"713","author":"Maurer","year":"1998","journal-title":"Journal of Chromatography. B, Biomedical Sciences and Applications"},{"key":"2024020109375062200_R36","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.forsciint.2006.05.021","article-title":"Validation of\u00a0new methods","volume":"165","author":"Peters","year":"2007","journal-title":"Forensic Science International"},{"key":"2024020109375062200_R37","article-title":"American Academy of\u00a0Forensic Sciences (AAFS), sandard practices for\u00a0method validation in\u00a0forensic toxicology","author":"U.S. Standards Board","year":"2019"},{"key":"2024020109375062200_R38","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.1021\/ac020361s","article-title":"Strategies for\u00a0the assessment of\u00a0matrix effect in\u00a0quantitative bioanalytical methods based on\u00a0HPLC\u2013MS-MS","volume":"75","author":"Matuszewski","year":"2003","journal-title":"Analytical Chemistry"},{"key":"2024020109375062200_R39","article-title":"Guidelines on\u00a0performance criteria for\u00a0methods of\u00a0analysis for\u00a0the determination of\u00a0pesticide residues in\u00a0food and\u00a0feed (CXG 90-2017)","author":"CODEX COMMITTEE ON PESTICIDE RESICUES (CCPR), CODEX ALIMENTARIUS COMMISSION (CAC)","year":"2017"},{"key":"2024020109375062200_R40","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1093\/jat\/bkt054","article-title":"Scientific Working Group for\u00a0Forensic Toxicology (SWGTOX) standard practices for\u00a0method validation in\u00a0forensic toxicology","volume":"37","author":"SWGTOX","year":"2013","journal-title":"Journal of Analytical Toxicology"},{"key":"2024020109375062200_R41","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jchromb.2017.08.042","article-title":"A cost-effective LC\u2013MS-MS method for\u00a0identification and\u00a0quantification of\u00a0\u03b1-amanitin in\u00a0rat plasma: Application to toxicokinetic study","volume":"1064","author":"Li","year":"2017","journal-title":"Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences"},{"key":"2024020109375062200_R42","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1007\/BF01918382","article-title":"Fifty years of\u00a0amanitin","volume":"47","author":"Wieland","year":"1991","journal-title":"Experientia"},{"key":"2024020109375062200_R43","first-page":"365","article-title":"Epidemiological analysis of\u00a0mushroom poisoning incidents in\u00a0Changsha City from 2016 to 2020","volume":"34","author":"Ma","year":"2022","journal-title":"Chinese Journal of Food Hygiene"},{"key":"2024020109375062200_R44","first-page":"414","article-title":"Study on\u00a0cognition status and\u00a0influencing factors of\u00a0wild bacteria poisoning among residents in\u00a0a city of\u00a0Hunan Province","volume":"29","author":"Xiao","year":"2022","journal-title":"Practical Preventive Medicine"},{"key":"2024020109375062200_R45","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1111\/liv.13127","article-title":"Acute liver failure caused by mushroom poisoning: still a fork in\u00a0the road","volume":"36","author":"Ib\u00e1\u00f1ez-Samaniego","year":"2016","journal-title":"Liver International : Official Journal of the International Association for the Study of the Liver"},{"key":"2024020109375062200_R46","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.fct.2015.09.008","article-title":"Amanita phalloides poisoning: mechanisms of\u00a0toxicity and\u00a0treatment","volume":"86","author":"Garcia","year":"2015","journal-title":"Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association"},{"key":"2024020109375062200_R47","doi-asserted-by":"publisher","first-page":"946","DOI":"10.3852\/10-319","article-title":"Peptide toxin components of\u00a0Amanita exitialis basidiocarps","volume":"103","author":"Deng","year":"2011","journal-title":"Mycologia"},{"key":"2024020109375062200_R48","first-page":"262","article-title":"Fast determination of\u00a09 mushroom toxins in\u00a0wild fungus by liquid chromatography-tandem mass spectrometry","volume":"34","author":"Xu","year":"2022","journal-title":"Chinese Journal of Food Hygiene"},{"key":"2024020109375062200_R49","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2021.113069","article-title":"Occurrence and\u00a0chemotaxonomical analysis of\u00a0amatoxins in\u00a0Lepiota spp","volume":"195","author":"Sarawi","year":"2022","journal-title":"(Agaricales). Phytochemistry"}],"container-title":["Journal of Analytical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jat\/advance-article-pdf\/doi\/10.1093\/jat\/bkad081\/53329837\/bkad081.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jat\/article-pdf\/48\/1\/44\/56528764\/bkad081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jat\/article-pdf\/48\/1\/44\/56528764\/bkad081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T09:38:59Z","timestamp":1706780339000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jat\/article\/48\/1\/44\/7334456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,31]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,10,31]]},"published-print":{"date-parts":[[2024,1,31]]}},"URL":"https:\/\/doi.org\/10.1093\/jat\/bkad081","relation":{},"ISSN":["0146-4760","1945-2403"],"issn-type":[{"value":"0146-4760","type":"print"},{"value":"1945-2403","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1,1]]},"published":{"date-parts":[[2023,10,31]]}}}