{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:24:30Z","timestamp":1787009070664,"version":"build-2736575974"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Current guidelines recommend universal screening for substance use disorders in obstetric patients, and neonatal drug testing is also frequently performed. Meconium is often the preferred specimen type to detect neonatal drug exposure due to a longer window of detection compared to urine, but most laboratories send out meconium testing to specialized reference laboratories, which can delay results for several days or more. Here, we evaluate a rapid and definitive liquid chromatography\u2013tandem mass spectrometry method for neonatal urine drug testing and compare results obtained using this method to paired meconium drug testing in 1,424 neonates for amphetamines, cocaine, cannabinoids, opiates, oxycodone and phencyclidine. Urine testing showed equivalent sensitivity to current meconium methods for detecting in utero exposure to amphetamines and cocaine.<\/jats:p>","DOI":"10.1093\/jat\/bkad085","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T17:59:55Z","timestamp":1699552795000},"page":"99-103","source":"Crossref","is-referenced-by-count":4,"title":["High-sensitivity neonatal urine drug testing has similar positivity rates to meconium for\u00a0detecting\n                    <i>in utero<\/i>\n                    exposure to methamphetamine and\u00a0cocaine"],"prefix":"10.1093","volume":"48","author":[{"given":"Hannah M","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Pathology & Immunology, Washington University School of Medicine , 425 So Euclid Ave., St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3978-2858","authenticated-orcid":false,"given":"Stephen M","family":"Roper","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Washington University School of Medicine , 425 So Euclid Ave., St. Louis, MO 63110, USA"},{"name":"Department of Pediatrics, Washington University School of Medicine , 425 So Euclid Ave., St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7593-4092","authenticated-orcid":false,"given":"Dennis J","family":"Dietzen","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Washington University School of Medicine , 425 So Euclid Ave., St. Louis, MO 63110, USA"},{"name":"Department of Pediatrics, Washington University School of Medicine , 425 So Euclid Ave., St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3535-6707","authenticated-orcid":false,"given":"Bridgit O","family":"Crews","sequence":"additional","affiliation":[{"name":"Department of Pathology & Immunology, Washington University School of Medicine , 425 So Euclid Ave., St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"2024030117230225000_R1","article-title":"2019 NSDUH Detailed Tables","volume-title":"National Survey on Drug Use and Health","author":"Substance Abuse and Mental Health Services Administration","year":"2020"},{"key":"2024030117230225000_R2","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1097\/01.AOG.0000466371.86393.9b","article-title":"Committee opinion no. 633: alcohol abuse and\u00a0other substance use disorders: ethical issues in\u00a0obstetric and\u00a0gynecologic practice","volume":"125","author":"American College of Obstetricians and Gynecologists","year":"2015","journal-title":"Obstetrics and Gynecology"},{"key":"2024030117230225000_R3","doi-asserted-by":"crossref","first-page":"e540","DOI":"10.1542\/peds.2011-3212","article-title":"Neonatal drug withdrawal","volume":"129","author":"Hudak","year":"2012","journal-title":"Pediatrics"},{"key":"2024030117230225000_R4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.2020-029074","article-title":"Neonatal opioid withdrawal syndrome","volume":"146","author":"Patrick","year":"2020","journal-title":"Pediatrics"},{"key":"2024030117230225000_R5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.chiabu.2017.10.002","article-title":"Prenatal substance exposure diagnosed at birth and\u00a0infant involvement with child protective services","volume":"76","author":"Prindle","year":"2018","journal-title":"Child Abuse & Neglect"},{"key":"2024030117230225000_R6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jpeds.2020.03.036","article-title":"Factors associated with child welfare involvement among prenatally substance-exposed infants","volume":"222","author":"Deutsch","year":"2020","journal-title":"The Journal of Pediatrics"},{"key":"2024030117230225000_R7","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1111\/1468-0009.12591","article-title":"Development and\u00a0implementation of\u00a0state and\u00a0federal child welfare laws related to drug use in\u00a0pregnancy","volume":"100","author":"McCOURT","year":"2022","journal-title":"The Milbank Quarterly"},{"key":"2024030117230225000_R8","article-title":"Ferguson v. Charleston, 532 U.S. 67","author":"Justia Law","year":"2001"},{"key":"2024030117230225000_R9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/FTD.0000000000000485","article-title":"Detection of\u00a0drug-exposed newborns","volume":"40","author":"Wabuyele","year":"2018","journal-title":"Therapeutic Drug Monitoring"},{"key":"2024030117230225000_R10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clinbiochem.2022.11.002","article-title":"Drug testing in\u00a0support of\u00a0the diagnosis of\u00a0neonatal abstinence syndrome: the current situation","volume":"111","author":"Langman","year":"2023","journal-title":"Clinical Biochemistry"},{"key":"2024030117230225000_R11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/jat\/bkac037","article-title":"Can umbilical cord and\u00a0meconium results be directly compared? Analytical approach matters","volume":"47","author":"Pandya","year":"2023","journal-title":"Journal of Analytical Toxicology"},{"key":"2024030117230225000_R12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/clinchem\/43.1.235","article-title":"Detection of\u00a0intrauterine illicit drug exposure by newborn drug testing","volume":"43","author":"Kwong","year":"1997","journal-title":"Clinical Chemistry"},{"key":"2024030117230225000_R13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/17425255.2018.1432595","article-title":"Drug metabolism in\u00a0early infancy: opioids as an illustration","volume":"14","author":"Van Donge","year":"2018","journal-title":"Expert Opinion on Drug Metabolism & Toxicology"},{"key":"2024030117230225000_R14","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0022-3476(89)80860-1","article-title":"Drug screening of\u00a0meconium in\u00a0infants of\u00a0drug-dependent mothers: an alternative to urine testing","volume":"115","author":"Ostrea","year":"1989","journal-title":"The Journal of Pediatrics"},{"key":"2024030117230225000_R15","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0022-3476(87)80125-7","article-title":"Perinatal cocaine and\u00a0methamphetamine exposure: maternal and\u00a0neonatal correlates","volume":"111","author":"Oro","year":"1987","journal-title":"The Journal of Pediatrics"},{"key":"2024030117230225000_R16","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1093\/clinchem\/36.6.1256","article-title":"Drugs of\u00a0abuse in\u00a0a pediatric outpatient population","volume":"36","author":"Hicks","year":"1990","journal-title":"Clinical Chemistry"},{"key":"2024030117230225000_R17","first-page":"988","article-title":"Detection of\u00a0cocaine exposure in\u00a0the neonate. 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