{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:35:00Z","timestamp":1790670900885,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A simple and rapid qualitative chromatographic method with a unique extraction approach was developed and validated to screen oral fluid samples for 31 compounds in driving under the influence of drugs investigations. The scope and sensitivity of the method meets or exceeds Tier I recommendations established by the National Safety Council\u2019s Alcohol, Drugs and Impairment Division. Since this is a targeted chromatographic screen (rather than an immunoassay), cutoffs were set to match the confirmation levels in the recommendations. Sample preparation involved a single-step liquid\u2013liquid extraction procedure, using a mixture of methyl tert-butyl ether, isopropanol, and hexane and was applied to samples collected with the Quantisal\u2122 device. Instrument analysis was conducted by liquid chromatography\u2013tandem mass spectrometry, using a Restek Raptor\u2122 biphenyl column for chromatographic separations and a total run time of 8 min. Validation results met\u00a0all requirements of ANSI\/ASB Standard 036 (1st edition)\u2014Standard Practices for Method Validation in Forensic Toxicology.<\/jats:p>","DOI":"10.1093\/jat\/bkae068","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T10:09:31Z","timestamp":1725530971000},"page":"528-534","source":"Crossref","is-referenced-by-count":5,"title":["Development and validation of a simple chromatographic method to screen oral fluid samples for drugs in DUID investigations"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2216-6131","authenticated-orcid":false,"given":"Gregory G","family":"Sarris","sequence":"first","affiliation":[{"name":"New York State Police Forensic Investigation Center , Toxicology, 1220 Washington Ave, Bldg 30, Albany, NY 12226,","place":["United 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